The Leukemia Stem Cell

Part of the Cancer Treatment and Research book series (CTAR, volume 145)


In a meeting held in the Charité Hospital in Berlin in 1909, Alexander Maximow postulated that all circulating blood cells arise from a single lymphocyte-like cell [68]. An almost identical hypothesis was proposed by Artur Pappenheim in 1917 [78]. This hypothesis was tested years later by numerous investigators who demonstrated that all hematopoietic cells arise from a single hematopoietic stem cell (HSC) [54, 75, 90, 116]. Our knowledge of the leukemogenic process has benefited from hematopoiesis research. Identification and characterization of the HSC led to the theory that leukemia is a stem cell disease, i.e., that leukemia arises from a neoplastic HSC.


Acute Myeloid Leukemia Hematopoietic Stem Cell Minimal Residual Disease Leukemia Stem Cell Circulate Blood Cell 



I thank Dawn Chalaire for editing this manuscript.


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.The Department of LeukemiaThe University of Texas MD, Anderson Cancer CenterHoustonUSA

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