The Liver-Impaired Patient
Among all organs in the human body, the liver is the largest and carries out the greatest number of functions. The liver’s important and multiple activities have impact on all body systems, including the nervous system. The relationship between the liver and the brain has been known for centuries (Frerichs, 1860; Lewis and Howdle, 2003; Tarter et al., 1989;Wilson, 1912). Patients with hepatic dysfunction frequently experience neuropsychiatric syndromes, of which the most well known is hepatic encephalopathy (Ferenci et al., 2002).
KeywordsLiver Disease Chronic Hepatitis Hepatic Encephalopathy Sustained Virologic Response Alcoholic Liver Disease
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- Center for Disease Control, National Center for Health Statistics, HEA, US. Leading causes of death and numbers of deaths, according to age. United States 1980 and 2003. Hyattsville, MD: CDC, 2005:182–183; available at http://www.cdc.gov/nchs/data/hus/hus05.pdf.
- Frerichs FT. A Clinical Treatise on Diseases of the Liver by Dr. Friedrich Theodor Frerichs (trans. Charles Murchison). London: New Sydenham Society, 1860:193–246.Google Scholar
- Hensley DA, Withers NW. Addiction psychiatric assessment of veterans with chronic hepatitis C. J Psychosom Res 2003;55:121.Google Scholar
- Hensley DA, Withers NW, Spira J. Aggression, depression, anxiety and quality of life in veterans with chronic hepatitis C. J Psychosom 2003;55:121–122.Google Scholar
- Lewis M, Howdle PD. The Neurology of Liver Failure. Q J Med 2003;96:623–633.Google Scholar
- Lieber CS. Pathogenesis and treatment of alcoholic liver disease: progress in the last 50 years. Roczniki Akademii Medycznej Biaymstoku 2005;50:7–20.Google Scholar
- Pantiaga C, Rodrigo LR, Cuesta M, Lopez L, Arias JL (2003). Cognitive deficits in patients with hepatic cirrhosis and in liver transplant recipients. Journal of Neuropsychology & Clinical Neuroscience, 15:84–89.Google Scholar
- Tarter RE, Edwards KL, Van Thiel D. Neuropsychological dysfunction due to liver disease. In: Tarter RE, Van Thiel DH, Edwards KL, eds. Medical Neuropsychology. New York: Plenum Press, 1989:95–97.Google Scholar
- Walton NW, Bowden SC. Does liver dysfunction explain neuropsychological status in recently detoxified alcoholic-dependent clients? Alcohol 1997;32:287–295.Google Scholar
- Withers NW. Aggression induced by interferon alfa-2b during long-term therapy for chronic hepatitis C. J Neuropsychiatry Clin Neurosci 2003;15:259.Google Scholar
- Withers NW. Deceptions in addiction psychiatry. Am J Forensic Psychiatry 2001;22:7–26.Google Scholar