Pancreatic Progenitor Cells in Injury and Regeneration

  • Solomon Afelik
  • Jan Jensen
Part of the M. D. Anderson Solid Tumor Oncology Series book series (MDA)

The pancreas is presently receiving attention for different reasons. Pancreatic cancer is among the most lethal cancers, and treatment options are limited. Treatment modalities for acute or chronic pancreatitis are similarly narrow. Furthermore, as the organ is the home turf for the endocrine islets of Langerhans, it is also a keen subject for researchers investigating issues related to the etiology, and possible cures, of type I and II diabetes. It is now known that both the exocrine and endocrine pancreas share a common progenitor. This progenitor may be the culprit in pancreatic cancer development, and at the same time represent the cell type providing most hope to successfully developing an islet cell replacement therapy for diabetes. No wonder then, ℌpancreatic progenitor existenceℍ as a subject is receiving attention. This chapter provides a review of current issues on the nature and function of both embryonic, and adult pancreatic progenitor cells, finding that research in pancreatic cancer, embryonic development, and adult regeneration starts to build a picture of adult cell plasticity that one day might be harnessed for therapeutic use.


Pancreatic Cancer Acinar Cell Notch Signaling Pancreatic Acinar Cell AR42J Cell 
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Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • Solomon Afelik
    • 1
  • Jan Jensen
    • 1
  1. 1.Barbara Davis Center for Childhood DiabetesUniversity of Colorado, HSCDenverUSA

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