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Inactivation of NF-κB

  • Fazlul H. Sarkar
  • Yiwei Li
Part of the M. D. Anderson Solid Tumor Oncology Series book series (MDA)

Pancreatic cancer is the fourth leading cause of cancer-related deaths among adults in the United States, with an estimated 37,170 new cases and 33,370 deaths in 2007 (1). Only 5% of all patients with pancreatic cancer survive 5 years after diagnosis (1). Even for those patients diagnosed with local disease, the 5-year survival rate is only 20%. The presence of occult or clinical metastases at the time of diagnosis together with the lack of effective chemotherapies contributes to the high mortality in patients with pancreatic cancer. Cancer cells’ resistance to chemotherapeutic agents is also a major cause of treatment failure in most solid tumors, especially for pancreatic cancer. The major culprits involved in the drug resistance include multidrug resistance gene (MDR), NF-κB, and Akt. Among them, NF-κB is an important molecule and is considered to be the master switch that promotes cell survival and protects cells from apoptotic cell death (2, 3).

Keywords

Pancreatic Cancer Pancreatic Cancer Cell Human Pancreatic Cancer Pancreatic Cancer Cell Line Human Pancreatic Cancer Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • Fazlul H. Sarkar
    • 1
  • Yiwei Li
    • 1
  1. 1.Karmanos Cancer InstituteWayne State University School of MedicineDetroitUSA

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