Complications of Pancreaticoduodenectomy

  • Kyla Terhune
  • Nipun B. Merchant
  • Alexander A. Parikh
Part of the M. D. Anderson Solid Tumor Oncology Series book series (MDA)

Although pancreaticoduodenectomy (PD) was initially performed by Kausch in 1909 and popularized by Allen Whipple in 1935, the operation was traditionally regarded with significant skepticism due to high mortality and morbidity rates. During the past two decades, however, PD has slowly gained acceptance as a safe and effective treatment modality for both malignant and benign diseases of the periampullary region. Due to advances in operative technique and perioperative care, perioperative mortality rates have generally declined from 25–30% to <5% at high-volume centers (1–3). Nevertheless, morbidity rates are still significant—between 30% and 50% in many series (1, 3–5). Given the poor overall survival even in successfully resected patients and the continued need for aggressive and often toxic adjuvant therapy regimens, the impact for postoperative morbidity on the patient’s quality of life as well their ability to receive these adjuvant therapies is even more significant. This chapter reviews the most common complications following PD including the diagnosis, risk factors, prevention, and treatment.


Gastric Emptying Pancreatic Fistula Distal Pancreatectomy Pancreatic Resection Preoperative Biliary Drainage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • Kyla Terhune
    • 1
  • Nipun B. Merchant
    • 1
  • Alexander A. Parikh
    • 1
  1. 1.Vanderbilt University School of MedicineNashvilleUSA

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