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Pancreatic Cancer pp 365–384Cite as

Complications of Pancreaticoduodenectomy

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Part of the book series: M. D. Anderson Solid Tumor Oncology Series ((MDA))

Although pancreaticoduodenectomy (PD) was initially performed by Kausch in 1909 and popularized by Allen Whipple in 1935, the operation was traditionally regarded with significant skepticism due to high mortality and morbidity rates. During the past two decades, however, PD has slowly gained acceptance as a safe and effective treatment modality for both malignant and benign diseases of the periampullary region. Due to advances in operative technique and perioperative care, perioperative mortality rates have generally declined from 25–30% to <5% at high-volume centers (1–3). Nevertheless, morbidity rates are still significant—between 30% and 50% in many series (1, 3–5). Given the poor overall survival even in successfully resected patients and the continued need for aggressive and often toxic adjuvant therapy regimens, the impact for postoperative morbidity on the patient’s quality of life as well their ability to receive these adjuvant therapies is even more significant. This chapter reviews the most common complications following PD including the diagnosis, risk factors, prevention, and treatment.

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Authors and Affiliations

  1. Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Kyla Terhune MD, Nipun B. Merchant MD & Alexander A. Parikh MD

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  1. Kyla Terhune MD
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Editors and Affiliations

  1. University of California San Diego, La Jolla, CA, USA

    Andrew M. Lowy

  2. School of Medicine, Johns Hopkins University, Baltimore, MD, USA

    Steven D. Leach

  3. Wayne State University, Detroit, MI, USA

    Philip A. Philip

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Terhune, K., Merchant, N.B., Parikh, A.A. (2008). Complications of Pancreaticoduodenectomy. In: Lowy, A.M., Leach, S.D., Philip, P.A. (eds) Pancreatic Cancer. M. D. Anderson Solid Tumor Oncology Series. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-69252-4_21

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  • Print ISBN: 978-0-387-69250-0

  • Online ISBN: 978-0-387-69252-4

  • eBook Packages: MedicineMedicine (R0)

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