Spectrum of Human Pancreatic Neoplasia

  • N. Volkan Adsay
  • Duangpen Thirabanjasak
  • Deniz Altinel
Part of the M. D. Anderson Solid Tumor Oncology Series book series (MDA)

Classification of pancreatic neoplasia is based on their cellular lineage, i.e which histologic cell type of the pancreas they recapitulate, which is in essence the main determinant of their clinicopathologic and biologic characteristics. Virtually every cell type that exists in the pancreas has been described to have one or more neoplastic counterparts.

Cellular components of the pancreas can be regarded under six categories ( 1 ) (Fig. 1.1 ): (1) acinar and (2) ductal, which together constitute the exocrine component of the organ responsible for the production of digestive enzymes (trypsin, chymotrypsin, lipases, and others) and their transportation to the duodenum, respectively; (3) islets of Langerhans, the endocrine component, which is responsible for the production of hormones involved in regulation of glucose and other metabolic activities; (4) ambiguous cells, such as centroacinar cells, which are less well characterized; (5) supportive elements, which encompass fibrous tissue, vessels, nerves, and other connective tissue elements; and (6) “potential” cells, such as stem cells, the existence of which is evidenced based on in vitro studies, but their representatives in normal human pancreata have not yet been clearly identified in histologic sections ( 2 ).

In the ensuing text, an overview of the clinicopathologic characteristics of pancreatic neoplasia is discussed based on their lineage. Emphasis is given to those that are more common and not covered in the other chapters of this book.


Chronic Pancreatitis Intraductal Papillary Mucinous Neoplasm Pancreatic Endocrine Neoplasm Serous Cystadenomas Pancreatic Intraepithelial Neoplasia 
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Copyright information

© Springer Science + Business Media, LLC 2008

Authors and Affiliations

  • N. Volkan Adsay
    • 1
  • Duangpen Thirabanjasak
    • 2
  • Deniz Altinel
    • 1
  1. 1.Department of PathologyEmory University HospitalsAtlantaUSA
  2. 2.Chulalongkorn UniversityBangkokThailand

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