Ovarian Steroidogenic Abnormalities in PCOS

  • Jessica K. Wickenheisser
  • Jan M. McAllister
Part of the Endocrine Updates book series (ENDO, volume 27)

Androgen excess, theca, granulosa, polycystic ovary syndrome, steroidogenesis, folliculogenesis, estrogen, insulin sensitivity, signaling defect. Polycystic ovary syndrome (PCOS) is a common, clinically heterogeneous disorder that affects approximately 6–10% of premenopausal women [1, 2]. Hyperandrogenemia is the biochemical hallmark of PCOS. Reproductive and endocrine abnormalities include disordered gonadotropin secretion, oligomenorrhea and anovulatory infertility, and endometrial hyperplasia. Obesity, hirsutism, acne, and alopecia are often associated with PCOS. The metabolic consequences of PCOS include insulin resistance, lipid abnormalities, and possibly an increased risk of cardiovascular disease [3].


Granulosa Cell Polycystic Ovary Polycystic Ovary Syndrome Follicular Fluid Theca Cell 
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Copyright information

© Springer 2007

Authors and Affiliations

  • Jessica K. Wickenheisser
    • 1
  • Jan M. McAllister
    • 2
  1. 1.Departments of Cellular and Molecular PhysiologyPennsylvania State University College of MedicineHershey
  2. 2.Department of Cellular and Molecular PhysiologyPenn State Hershey College of MedicineHershey

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