Genetics of PCOS
Candidate gene, association, linkage, single nucleotide polymorphism, haplotype Polycystic ovary syndrome (PCOS) is considered a common, complex genetic disorder, as are conditions such as schizophrenia, asthma, and type 2 diabetes. Such common diseases, including PCOS, appear to have a complex, multifactorial etiology, wherein a variety of predisposing genes, not just one gene, interact with environmental and lifestyle factors to produce disease. Studies in families demonstrated the heritable nature of PCOS itself as well as the component phenotypes of PCOS. This has led to a large number of population studies attempting to discover genes that influence PCOS using the candidate gene approach.
KeywordsAndrogen Receptor Polycystic Ovary Syndrome Haplotype Block Candidate Gene Approach Androgen Receptor Gene
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