Chemotherapy for Brain Metastases due to Lung Cancer and Melanoma

  • Marc C Chamberlain
Part of the Cancer Treatment and Research book series (CTAR, volume 136)


Several issues are pertinent to a discussion of chemotherapy for brain metastases (BM) [Table 1]. First and most important, there is a paucity of clinical trials with very few randomized trials [1–6]. The limited evidence supporting the use of chemotherapy for BM comes from nonrandomized, retrospective studies and case reports. Second, survival is often limited by death from systemic disease (approximately 30% of patients with BM die as a direct result of central nervous system disease). Patients with BM are heterogeneous and the importance of stratification for prognostic factors for example by way of the Radiation Treatment Oncology Group recursive portioning analysis (RTOG RPA) is often overlooked [7].


Brain Metastasis Clin Oncol Small Cell Lung Cancer Recursive Partitioning Analysis Cerebral Metastasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Marc C Chamberlain
    • 1
  1. 1.Department of NeurologyUniversity of Washington Fred Hutchinson Cancer Research Center Seattle Cancer Care AllianceSeattleUSA

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