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Chemotherapy for Brain Metastases: Breast, Gynecologic and Non-Melanoma Skin Malignancies

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Brain Metastases

Part of the book series: Cancer Treatment and Research ((CTAR,volume 136))

Abstract

Greater than one-half of all intracranial tumors in adults represent metastases from disseminated systemic malignancies. Abundant class I evidence has been accumulated for the past two decades that demonstrates improved survival and quality of life with surgical resection or SRS for appropriate patients. In some tumor types, WBRT can effectively treat, prevent and/or delay recurrences and improve survival as well. However, several factors may preclude either surgery or radiation therapy (e.g., number of metastases, co-existing medical or neurological conditions) and in such patients the mainstay of treatment is chemotherapy or other biologic targeted therapy.

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Author information

Authors and Affiliations

  1. Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10021, USA

    Gaurav D. Shah MD & Lauren E. Abrey MD

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  1. Gaurav D. Shah MD
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  2. Lauren E. Abrey MD
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Editors and Affiliations

  1. Feinberg School of Medicine Robert H. Lurie Comprehensive Cancer Center Department of Neurology, Northwestern University, Chicago, IL, 60611, USA

    Jeffrey J. Raizer MD

  2. Department of Neurology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10021, USA

    Lauren E. Abrey MD

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Shah, G.D., Abrey, L.E. (2007). Chemotherapy for Brain Metastases: Breast, Gynecologic and Non-Melanoma Skin Malignancies. In: Raizer, J.J., Abrey, L.E. (eds) Brain Metastases. Cancer Treatment and Research, vol 136. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-69222-7_10

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  • DOI: https://doi.org/10.1007/978-0-387-69222-7_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-69221-0

  • Online ISBN: 978-0-387-69222-7

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