Sentinel Node Identification using Radionuclides in Melanoma and Breast Cancer

  • Edwin Glass
Part of the Cancer Treatment and Research book series (CTAR, volume 135)

The metastatic spread of breast cancer to regional lymph nodes has been recognized for centuries (1), and the propensity of melanoma for lymphatic spread was documented in the nineteenth century (2).The basis for the sentinel node hypothesis is that tumors with a propensity for lymphatic invasion initially spread preferentially to nodes located on their draining lymphatic pathways. Hence these lymph nodes are the ones most likely to contain metastatic cells (3, 4), and they can be regarded as sentinel for the lymphatic spread of the cancer. Knowledge of the tumor status of these sentinel lymph nodes is now recognized as essential for staging and treating malignancies with a propensity for lymphatic invasion. Before discussing the mechanics and details of sentinel node localization, it is worthwhile to review relevant lymphatic physiology.


Breast Cancer Sentinel Node Lymphatic Mapping Sentinel Node Procedure Isosulfan Blue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Edwin Glass
    • 1
  1. 1.John Wayne Cancer InstituteSanta MonicaUSA

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