Future Perspectives and Unanswered Questions on Cancer Metastasis and the Lymphovascular System
For the clinical oncologist, the most humbling experience is when the cancer has spread and the disease is unresponsive to available therapy to curb progression.Paget developed the “seed and soil” hypothesis to explain the phenomenon of clinical cancer metastasis (1). Since the work of Paget, we have seen explosive advances in biological understanding of the mechanisms of metastasis. Numerous animal models have been applied to further understand the cellular and molecular mechanisms of cancer metastasis (2). But the translational link to the clinic from such basic science advances continues to remain elusive. It is important, therefore, to bring clinicians and basic scientists together to share their knowledge and perspectives on the phenomena surrounding cancer metastasis. For this reason, the first International Symposium on Cancer Metastasis and the Lymphovascular System was organized and successfully held in San Francisco in April 2005. The meeting highlights have been summarized in the June issue of 2006 Cancer Metastasis Reviews.
KeywordsAcute Myeloid Leukemia Cancer Metastasis Lymphatic Channel Tumorigenic Breast Cancer Cell Invade Cancer Cell
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