New Promises in the Adjuvant, and Palliative Treatment of Melanoma

  • Claus Garbe
  • Selma Ugurel
  • Katharina C. Kähler
  • Axel Hauschild
  • Dirk Schadendorf
Part of the Cancer Treatment and Research book series (CTAR, volume 135)

In the last decade the incidence of melanoma has been increasing. Malignant melanoma of the skin is the most frequent cause of mortality from skin cancer. Despite exhaustive efforts to increase early detection and in prevention campaigns, 20–25% of all melanoma patients will die due to disseminated metastases. Once melanoma has spread to regional lymph nodes, survival diminishes to approximately 30–55%. After dissemination to visceral organs, only very few patients can be cured. The median survival with stage IV (AJCC classification) disseminated melanoma is approximately 6–12 months. To date, therapy of disseminated melanoma still has failed to show a significant impact on overall survival. In the adjuvant setting interferon-α is until today the only drug which has shown beneficial effects in high-risk cutaneous melanoma patients. In addition to the development of new targeted drugs the identification of patient subgroups with anticipated benefit will be of importance.


Clin Oncol Melanoma Patient Chemosensitivity Testing Chemosensitivity Assay Adjuvant Interferon 
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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Claus Garbe
    • 1
  • Selma Ugurel
    • 2
  • Katharina C. Kähler
    • 3
  • Axel Hauschild
    • 3
  • Dirk Schadendorf
    • 2
  1. 1.Department of DermatologyUniversity Medical CenterGermany
  2. 2.German Cancer Research Centre and University Hospital MannheimUniversity of HeidelbergGermany
  3. 3.Department of DermatologyUniversity of KielGermany

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