Significance of Regional Draining Lymph Nodes in the Development of Tumor Immunity: Implications for Cancer Immunotherapy

  • Rongxiu Zheng
  • Jorgen Kjaergaard
  • Walter T. Lee
  • Peter A. Cohen
  • Suyu Shu
Part of the Cancer Treatment and Research book series (CTAR, volume 135)

For the majority of human solid cancer, regional draining lymph nodes (LNs) are the initial target of metastases and the LN status serves as the most important prognostic indicator for clinical outcome of patients. In patients with cutaneous melanoma who develop metastases, tumor most often first presents in the ipsilateral regional nodes and appears preferentially in the first LN on the direct lymphatic drainage pathway from a primary melanoma (1, 2).


Cancer Immunotherapy Adoptive Immunotherapy Fusion Hybrid Vaccine Site Systemic Antitumor Immunity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Rongxiu Zheng
    • 1
  • Jorgen Kjaergaard
    • 2
  • Walter T. Lee
    • 1
  • Peter A. Cohen
    • 1
  • Suyu Shu
    • 1
  1. 1.Center for Surgery ResearchCleveland ClinicClevelandUSA
  2. 2.New England Inflammation and Tissue Protection InstituteNortheastern UniversityBostonUSA

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