Regional Lymph Node Metastases, a Singular Manifestation of the Process of Clinical Metastases in Cancer: Contemporary Animal Research And Clinical Reports Suggest Unifying Concepts

  • Blake Cady
Part of the Cancer Treatment and Research book series (CTAR, volume 135)

Extensive animal research into the process of metastatic development of cancers over recent years provides insight into clinical findings in patients. Clinical research and reports provide strong support for the translation of these research conclusions from the laboratory and animals to human cancers (1–6), particularly in understanding the role of lymph node metastases but also more distant metastases in almost all human epithelial cancers (2, 3). The following chapter describes an interpretation of the generic issues in metastatic development by using specific clinical examples and reports, and summarizing laboratory and animal research, whether cancer cells that result in eventual clinical metastases begin their initial journey via the lymphatic or hematogenous route.


Breast Cancer Sentinel Node Sentinel Node Biopsy Carcinoid Tumor Axillary Dissection 
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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Blake Cady
    • 1
  1. 1.Department of SurgeryBrown Medical School, Rhode Island HospitalProvidenceUSA

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