Effects of Chemokines on Tumor Metastasis

  • Hiroya Takeuchi
  • Minoru Kitago
  • David S. B. Hoon
Part of the Cancer Treatment and Research book series (CTAR, volume 135)

One of the puzzling questions in the study of cancer metastasis has been:“Why do tumor cells metastasize preferably to specific organs and not to others?”The mechanism of cancer metastasis has been debated for several decades after the “seed and soil” theory, which was described by Paget (1). Paget theorized that cancer metastasis preferentially occur to organs or sites that support the growth of cancer cells. On the other hand, Ewing (2) described “anatomical mechanical theory” to account for cancer metastasis. He theorized that the patterns of blood flow from the primary tumor can predict the first metastasized organs. Recent progress in cancer metastasis biology has introduced development of a new concept, “homing theory,” which incorporates the previous two theories to describe the mechanics associated with cancer metastasis. It is hypothesized that cancer cells are drawn to specific organ sites as a result of complex signaling between the tumor cells and the cells of the organ (3).


Melanoma Cell CXCR4 Expression Ligand Axis Chemokine Receptor CCR7 High Endothelial Venule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Hiroya Takeuchi
    • 1
  • Minoru Kitago
    • 2
  • David S. B. Hoon
    • 2
  1. 1.Department of SurgeryKeio University School of MedicineJapan
  2. 2.Department of Molecular OncologyJohn Wayne Cancer Institute, Saint Johns Health CenterSanta MonicaUSA

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