A New Breast Cancer Model for Lymphatic Metastasis

  • Michael M. Lizardo
  • Ian C. MacDonald
  • Alan B. Tuck
  • Ann F. Chambers
Part of the Cancer Treatment and Research book series (CTAR, volume 135)

Lymphatic vessels provide one of the main anatomical routes by which invasive tumor cells can disseminate from the primary tumor. Certain types of cancer, breast cancer in particular, have a propensity to disseminate via the lymphatics.Yet despite the prevalence of lymphatic metastasis, experimental work elucidating the underlying biology, until recently, has been relatively limited. In the past several years, experimental metastasis research has experienced a surge in the number of studies examining the molecular determinants of lymphatic metastasis, as well as in vivo imaging of its progression in animal models.The following review aims to highlight recent preclinical experimental work that contributes to our basic understanding of lymphatic metastasis in breast cancer, and to describe a recently developed human cell model for lymphatic metastasis. Before continuing, however, a brief overview of clinical and pathological studies that detail the natural history of lymphatic metastasis in breast cancer will set the disease model, which experimental models must mimic.


Breast Cancer Lymphatic Vessel Lymphatic Invasion Lymphatic Metastasis Lymphatic Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Michael M. Lizardo
    • 1
  • Ian C. MacDonald
    • 1
  • Alan B. Tuck
    • 2
  • Ann F. Chambers
    • 3
  1. 1.Department of Medical BiophysicsUniversity of Western OntarioLondonCanada
  2. 2.Department of PathologyLondon Health Sciences CenterLondonCanada
  3. 3.London Regional Cancer ProgramLondonCanada

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