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The Biology of Gastric Cancers pp 235–250Cite as

Role of Host Genetic Susceptibility in the Pathogenesis of Gastric Cancer

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References

  1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005;55:74–108.

    Article  PubMed  Google Scholar 

  2. IARC monographs on the evaluation of carcinogenic risks to humans. Vol. 61. Schistosomes, liver flukes and Helicobacter pylori. Lyon: IARC; 1994:177–240.

    Google Scholar 

  3. Scott DR, Weeks D, Hong C, Postius S, Melchers K, Sachs G. The role of internal urease in acid resistance of Helicobacter pylori. Gastroenterology 1998;114:58–70.

    Article  CAS  PubMed  Google Scholar 

  4. Israel DA, Peek RM. Pathogenesis of Helicobacter pylori-induced gastric inflammation. Aliment Pharmacol Ther 2001;15:1271–90.

    Article  CAS  PubMed  Google Scholar 

  5. Robert A, Olafsson AS, Lancaster C, Zhang WR. Interleukin-1 is cytoprotective, antisecretory, stimulates PGE2 synthesis by the stomach, and retards gastric emptying. Life Sci 1991;48:123–34.

    Article  CAS  PubMed  Google Scholar 

  6. Wolfe MM, Nompleggi DJ. Cytokine inhibition of gastric acid secretion: a little goes a long way. Gastroenterology 1992;102:2177–8.

    CAS  PubMed  Google Scholar 

  7. Beales IL, Calam J. Interleukin 1 beta and tumour necrosis factor alpha inhibit acid secretion in cultured rabbit parietal cells by multiple pathways. Gut 1998;42:227–34.

    Article  CAS  PubMed  Google Scholar 

  8. Graham DY, Opekun AR, Osato MS, El-Zimaity HMT, Lee CK, Yamaoka Y, Qureshi WA, Cadoz M, Monath TP. Challenge model for Helicobacter pylori infection in human volunteers. Gut 2004;53:1235–43.

    Article  CAS  PubMed  Google Scholar 

  9. Danon SJ, O'Rourke JL, Moss ND, Lee A. The importance of local acid production in the distribution of Helicobacter felis in the mouse stomach. Gastroenterology 1995;108:1386–95.

    Article  CAS  PubMed  Google Scholar 

  10. Kuipers EJ, Lundell L, Klinkenberg-Knol EC, Havu N, Festen HP, Liedman B, Lamers CB, Jansen JB, Dalenback J, Snel P, Nelis GF, Meuwissen SG. Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication. N Engl J Med 1996;334:1018–22.

    Article  CAS  PubMed  Google Scholar 

  11. El-Omar EM, Oien K, El Nujumi A, Gillen D, Wirz A, Dahill S, Williams C, Ardill JE, McColl KE. Helicobacter pylori infection and chronic gastric acid hyposecretion. Gastroenterology 1997;113:15–24.

    Article  CAS  PubMed  Google Scholar 

  12. El-Omar EM, Penman ID, Ardill JE, Chittajallu RS, Howie C, McColl KE. Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease. Gastroenterology 1995;109:681–91.

    Article  CAS  PubMed  Google Scholar 

  13. McColl KE, El-Omar E, Gillen D. Helicobacter pylori gastritis and gastric physiology. Gastroenterol Clin North Am 2000;29:687–703.

    Article  CAS  PubMed  Google Scholar 

  14. Graham DY, Yamaoka Y. Disease-specific Helicobacter pylori virulence factors: the unfulfilled promise. Helicobacter 2000;5(Suppl 1):S3–S9.

    Article  PubMed  Google Scholar 

  15. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996;87:2095–147.

    CAS  PubMed  Google Scholar 

  16. El-Omar EM. The importance of interleukin 1beta in Helicobacter pylori associated disease. Gut 2001;48:743–7.

    Article  CAS  PubMed  Google Scholar 

  17. Bidwell J, Keen L, Gallagher G, Kimberly R, Huizinga T, McDermott MF, Oksenberg J, McNicholl J, Pociot F, Hardt C, D'Alfonso S. Cytokine gene polymorphism in human disease: on-line databases, supplement 1. Genes Immun 2001;2:61–70.

    Article  CAS  PubMed  Google Scholar 

  18. El-Omar EM, Carrington M, Chow WH, McColl KE, Bream JH, Young HA, Herrera J, Lissowska J, Yuan CC, Rothman N, Lanyon G, Martin M, Fraumeni JF, Jr., Rabkin CS. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 2000;404:398–402.

    Article  CAS  PubMed  Google Scholar 

  19. El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB, Stanford JL, Mayne ST, Goedert J, Blot WJ, Fraumeni JF, Jr., Chow WH. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 2003;124:1193–201.

    Article  CAS  PubMed  Google Scholar 

  20. Machado JC, Pharoah P, Sousa S, Carvalho R, Oliveira C, Figueiredo C, Amorim A, Seruca R, Caldas C, Carneiro F, Sobrinho-Simoes M. Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma. Gastroenterology 2001;121:823–9.

    Article  CAS  PubMed  Google Scholar 

  21. Figueiredo C, Machado JC, Pharoah P, Seruca R, Sousa S, Carvalho R, Capelinha AF, Quint W, Caldas C, Van Doorn LJ, Carneiro F, Sobrinho-Simoes M. Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer Inst 2002;94:1680–7.

    CAS  PubMed  Google Scholar 

  22. Machado JC, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S, Castro AC, Campos ML, Van Doorn LJ, Caldas C, Seruca R, Carneiro F, Sobrinho-Simoes M. A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology 2003;125:364–71.

    Article  CAS  PubMed  Google Scholar 

  23. Rad R, Prinz C, Neu B, Neuhofer M, Zeitner M, Voland P, Becker I, Schepp W, Gerhard M. Synergistic effect of Helicobacter pylori virulence factors and interleukin-1 polymorphisms for the development of severe histological changes in the gastric mucosa. J Infect Dis 2003;188:272–81.

    Article  CAS  PubMed  Google Scholar 

  24. Palli D, Saieva C, Luzzi I, Masala G, Topa S, Sera F, Gemma S, Zanna I, D'Errico M, Zini E, Guidotti S, Valeri A, Fabbrucci P, Moretti R, Testai E, del Giudice G, Ottini L, Matullo G, Dogliotti E, Gomez-Miguel MJ. Interleukin-1 gene polymorphisms and gastric cancer risk in a high-risk Italian population. Am J Gastroenterol 2005;100:1941–8.

    Article  CAS  PubMed  Google Scholar 

  25. Furuta T, El-Omar EM, Xiao F, Shirai N, Takashima M, Sugimurra H. Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. Gastroenterology 2002;123:92–105.

    Article  CAS  PubMed  Google Scholar 

  26. Zeng ZR, Hu PJ, Hu S, Pang RP, Chen MH, Ng M, Sung JJY. Association of interleukin 1B gene polymorphism and gastric cancers in high and low prevalence regions in China. Gut 2003;52:1684–9.

    Article  CAS  PubMed  Google Scholar 

  27. Lee KA, Ki CS, Kim HJ, Sohn KM, Kim JW, Kang WK, Rhee JC, Song SY, Sohn TS. Novel interleukin 1beta polymorphism increased the risk of gastric cancer in a Korean population. J Gastroenterol 2004;39:429–33.

    Article  CAS  PubMed  Google Scholar 

  28. Chang YW, Jang JY, Kim NH, Lee JW, Lee HJ, Jung WW, Dong SH, Kim HJ, Kim BH, Lee JI, Chang R. Interleukin-1B (IL-1B) polymorphisms and gastric mucosal levels of IL-1beta cytokine in Korean patients with gastric cancer. Int J Cancer 2005;114:465–71.

    Article  CAS  PubMed  Google Scholar 

  29. Yang J, Hu Z, Xu Y, Shen J, Niu J, Hu X, Guo J, Wei Q, Wang X, Shen H. Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population. Cancer Lett 2004;215:191–8.

    Article  CAS  PubMed  Google Scholar 

  30. Chen HM, Wilkins LM, Aziz N, Cannings C, Wyllie DH, Bingle C, Rogus J, Beck JD, Offenbacher S, Cork MJ, Rafie-Kolpin M, Hsieh CM, Kornman KS, Duff GW. Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context. Hum Mol Genet 2006;15:519–29.

    Article  CAS  PubMed  Google Scholar 

  31. Lee KA, Park JH, Sohn TS, Kim S, Rhee JC, Kim JW. Interaction of polymorphisms in the interleukin 1B-31 and general transcription factor 2A1 genes on the susceptibility to gastric cancer. Cytokine 2007;38:96–100.

    Article  CAS  PubMed  Google Scholar 

  32. Tu S, Cui G, Takaishi S, Tran AV, Frederick DM, Carlson JE, Kurt-Jones E, Wang TC. Overexpression of human interleukin-1 beta in transgenic mice results in spontaneous gastric inflammation and carcinogenesis. Gastroenterology 2005;128:A62.

    Article  Google Scholar 

  33. Smith MG, Hold GL, Rabkin CS, Chow WH, McColl KE, Perez-Perez GI, Mowat NAG, El-Omar EM. The IL-8-251 promoter polymorphism is associated with high IL-8 production, severe inflammation and increased risk of pre-malignant changes in H-pylori positive subjects. 2004;124:A23.

    Google Scholar 

  34. Taguchi A, Ohmiya N, Shirai K, Mabuchi N, Itoh A, Hirooka Y, Niwa Y, Goto H. Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. Cancer Epidemiol Biomarkers Prev 2005;14:2487–93.

    Article  CAS  PubMed  Google Scholar 

  35. Lu W, Pan K, Zhang L, Lin D, Miao X, You W. Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor a and risk of gastric cancer in a Chinese population. Carcinogenesis 2005;26:631–6.

    Article  CAS  PubMed  Google Scholar 

  36. Lee WP, Tai DI, Lan KH, Li AF, Hsu HC, Lin EJ, Lin YP, Sheu ML, Li CP, Chang FY, Chao Y, Yen SH, Lee SD. The -251T allele of the interleukin-8 promoter is associated with increased risk of gastric carcinoma featuring diffuse-type histopathology in Chinese population. Clin Cancer Res 2005;11:6431–41.

    Article  CAS  PubMed  Google Scholar 

  37. Ohyauchi M, Imatani A, Yonechi M, Asano N, Miura A, Iijima K, Koike T, Sekine H, Ohara S, Shimosegawa T. The polymorphism interleukin 8–251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population. Gut 2005;54:330–5.

    Article  CAS  PubMed  Google Scholar 

  38. Smith MG, Hold GL, Rabkin CS, Chow WH, Fraumeni JF, Jr., Mowat NAG, Ando T, Goto H, El-Omar EM. The interleukin-8-251 promoter polymorphism and risk of gastric cancer in Caucasian and Japanese populations. 2006; 128:A-19.

    Google Scholar 

  39. Kuipers EJ. Review article: exploring the link between Helicobacter pylori and gastric cancer. Aliment Pharmacol Ther 1999;13(Suppl 1):3–11.

    Article  PubMed  Google Scholar 

  40. Segal ED, Lange C, Covacci A, Tompkins LS, Falkow S. Induction of host signal transduction pathways by Helicobacter pylori. Proc Natl Acad Sci USA 1997;94:7595–9.

    Article  CAS  PubMed  Google Scholar 

  41. Su B, Ceponis PJ, Lebel S, Huynh H, Sherman PM. Helicobacter pylori activates Toll-like receptor 4 expression in gastrointestinal epithelial cells. Infect Immun 2003;71:3496–502.

    Article  CAS  PubMed  Google Scholar 

  42. Pasare C, Medzhitov R. Toll-like receptors: linking innate and adaptive immunity. Adv Exp Med Biol 2005;560:11–8.

    Article  CAS  PubMed  Google Scholar 

  43. Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol 2005;17:1–14.

    Article  CAS  PubMed  Google Scholar 

  44. Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000;25:187–91.

    Article  CAS  PubMed  Google Scholar 

  45. Franchimont D, Vermeire S, El Housni H, Pierik M, Van Steen K, Gustot T, Quertinmont E, Abramowicz M, Van Gossum A, Deviere J, Rutgeerts P. Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis. Gut 2004;53:987–92.

    Article  CAS  PubMed  Google Scholar 

  46. Lorenz E, Mira JP, Frees KL, Schwartz DA. Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch Intern Med 2002;162:1028–32.

    Article  CAS  PubMed  Google Scholar 

  47. Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Bonora E, Willeit J, Schwartz DA. Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 2002;347:185–92.

    Article  CAS  PubMed  Google Scholar 

  48. Higgins SC, Lavelle EC, McCann C, Keogh B, McNeela E, Byrne P, O'Gorman B, Jarnicki A, McGuirk P, Mills KH. Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology. J Immunol 2003;171:3119–27.

    CAS  PubMed  Google Scholar 

  49. Hold GL, Rabkin CS, Chow WH, Smith MG, Gammon MD, Risch HA, Vaughan TL, McColl KE, Lissowska J, Zatonski W, Schoenberg JB, Blot WJ, Mowat NA, Fraumeni JF, Jr., El-Omar EM. A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors. Gastroenterology 2007;132:905–12.

    Article  CAS  PubMed  Google Scholar 

  50. Sanduleanu S, Jonkers D, De Bruine A, Hameeteman W, Stockbrugger RW. Double gastric infection with Helicobacter pylori and non-Helicobacter pylori bacteria during acid-suppressive therapy: increase of pro-inflammatory cytokines and development of atrophic gastritis. Aliment Pharmacol Ther 2001;15:1163–75.

    Article  CAS  PubMed  Google Scholar 

  51. Zavros Y, Rieder G, Ferguson A, Samuelson LC, Merchant JL. Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice. Gastroenterology 2002;122:119–33.

    Article  PubMed  Google Scholar 

  52. Lee JE, Lowy AM, Thompson WA, Lu M, Loflin PT, Skibber JM, Evans DB, Curley SA, Mansfield PF, Reveille JD. Association of gastric adenocarcinoma with the HLA class II gene DQB10301. Gastroenterology 1996;111:426–32.

    Article  CAS  PubMed  Google Scholar 

  53. Azuma T, Ito S, Sato F, Yamazaki Y, Miyaji H, Ito Y, Suto H, Kuriyama M, Kato T, Kohli Y. The role of the HLA-DQA1 gene in resistance to atrophic gastritis and gastric adenocarcinoma induced by Helicobacter pylori infection. Cancer 1998;82:1013–8.

    Article  CAS  PubMed  Google Scholar 

  54. Magnusson PKE, Enroth H, Eriksson I, Held M, Nyren O, Engstrand L, Hansson LE, Gyllensten UB. Gastric cancer and human leukocyte antigen: distinct DQ and DR alleles are associated with development of gastric cancer and infection by Helicobacter pylori. Cancer Res 2001;61:2684–9.

    CAS  PubMed  Google Scholar 

  55. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process—First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 1992;52:6735–40.

    CAS  PubMed  Google Scholar 

  56. Mayne ST, Risch HA, Dubrow R, Chow WH, Gammon MD, Vaughan TL, Farrow DC, Schoenberg JB, Stanford JL, Ahsan H, West AB, Rotterdam H, Blot WJ, Fraumeni JF, Jr. Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev 2001;10:1055–62.

    CAS  PubMed  Google Scholar 

  57. Banerjee S, Hawksby C, Miller S, Dahill S, Beattie AD, McColl KE. Effect of Helicobacter pylori and its eradication on gastric juice ascorbic acid. Gut 1994;35:317–22.

    Article  CAS  PubMed  Google Scholar 

  58. Kneller RW, You WC, Chang YS, Liu WD, Zhang L, Zhao L, Xu GW, Fraumeni JF, Jr., Blot WJ. Cigarette smoking and other risk factors for progression of precancerous stomach lesions. J Natl Cancer Inst 1992;84:1261–6.

    Article  CAS  PubMed  Google Scholar 

  59. Stenström B, Zhao CM, Rogers AB, Nilsson HO, Sturegard E, Lundgren S, Fox JG, Wang TC, Wadstrom TM, Chen D. Swedish moist snuff accelerates gastric cancer development in Helicobacter pylori-infected wild-type and gastrin transgenic mice. Carcinogenesis 2007;28:2041–6.

    Article  PubMed  Google Scholar 

  60. El Omar EM. Role of host genes in sporadic gastric cancer. Best Pract Res Clin Gastroenterol 2006;20:675–86.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medicine and Therapeutics, Institute of Medical Sciences, Aberdeen University, Foresterhill, Aberdeen, Scotland

    Emad M. El-Omar

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  1. Emad M. El-Omar
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Editors and Affiliations

  1. Division of Digestive and Liver Diseases, Columbia University, New York, NY, USA

    Timothy C. Wang (Silberberg Professor of Medicine Chair) (Silberberg Professor of Medicine Chair)

  2. Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

    James G. Fox (Director, Professor) (Director, Professor)

  3. Immunity and Environment Murdoch Childrens Research Institute, Royal Melbourne Hospital Footscray, Melbourne, Australia

    Andrew S. Giraud (Professor and Research Theme Director Infection) (Professor and Research Theme Director Infection)

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El-Omar, E.M. (2009). Role of Host Genetic Susceptibility in the Pathogenesis of Gastric Cancer. In: Wang, T.C., Fox, J.G., Giraud, A.S. (eds) The Biology of Gastric Cancers. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69182-4_9

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