Human Gastric Neuroendocrine Neoplasia: Current Pathologic Status

  • Guido Rindi
  • Enrico Solcia


This chapter provides an overview of nonneoplastic (hyperplasia and dysplasia) and neoplastic endocrine cell lesions of the stomach [the carcinoid, or well-differentiated (neuro)endocrine tumor/carcinoma, and the poorly differentiated endocrine carcinoma, (PDEC)]. The normal endocrine cell counterparts are also briefly described.

The adjective “neuroendocrine” is widely used for this type of tumor and is considered a synonym of “endocrine,” as defined by the World Health Organization (WHO) which also maintains the traditional term “carcinoid.” All of these various tumor-connoting definitions are used synonymously throughout this chapter.

The Gastric Endocrine Cells

Five different endocrine cell types are described in the gastric mucosa of humans (Table 6.1) (Rindi et al. 2002a; Simonsson et al. 1988; Solcia et al. 1975, 2000a). The most represented endocrine cell type of the oxyntic mucosa is the histamine-producing, entero-chromaffin-like (ECL) cell (Figure 6.1A)....


Endocrine Cell Gastric Carcinoid Endocrine Cell Growth Oxyntic Mucosa Endocrine Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Guido Rindi
    • 1
  • Enrico Solcia
    • 2
  1. 1.Dipartimento di Patologia e Medicina di LaboratorioSezione di Anatomia Patologica, Universita' degli StudiParmaItaly
  2. 2.Dipartimento di Patologia Umana ed EreditariaSezione di Anatomia Patologica, Universiti PaviaPavisItaly

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