Gastrointestinal Stromal Tumors of Gastric Origin

  • Chandrajit P. Raut
  • Jason L. Hornick
  • Monica M. Bertagnolli


Gastrointestinal stromal tumors (GISTs) are rare neoplasms. Although they account for only 0.1%–3% of all gastrointestinal (GI) malignancies (Crosby et al. 2001; DeMatteo et al. 2000; Lewis and Brennan 1996; Nishida and Hirota 2000), they represent 80% of GI mesenchymal tumors (Miettinen and Lasota 2001). GISTs may arise from anywhere along the GI tract and exhibit a broad spectrum of clinical behavior. Many are asymptomatic, discovered incidentally during imaging, endoscopy, or laparotomy for unrelated reasons. GISTs exhibit a broad spectrum of clinical activity. Some remain stable for years, whereas others progress rapidly (DeMatteo et al. 2000; Fletcher et al. 2002). Metastases may be identified in 15%–50% of GISTs at the time of diagnosis (Bauer et al. 2003; Roberts and Eisenberg 2002).

Histologic and Molecular Classification

Until recently, the diagnostic criteria for GISTs were poorly defined because of their variable natural history, heterogeneous immunophenotype,...


National Comprehensive Cancer Network National Comprehensive Cancer Network Imatinib Mesylate PDGFRA Mutation Sunitinib Malate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Chandrajit P. Raut
    • 1
  • Jason L. Hornick
    • 2
  • Monica M. Bertagnolli
    • 3
  1. 1.Departments of Surgery and Pathology, Brigham & Women's Hospital, Center for Sarcoma and Bone OncologyDana-Farber Cancer Institute, and Harvard Medical SchoolBostonUSA
  2. 2.Brigham and Women's Hospital, Department of PathologyHarvard Medical School, Dana-Farber Cancer InstituteBostonUSA
  3. 3.Department of Surgery, Division of Surgical OncologyBrigham and Women's Hospital, Dana-Farber Cancer CenterBostonUSA

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