MALT Lymphoma: Clinicopathologic Features and Molecular Pathogenesis

  • Anne Müller


Extranodal marginal-zone B-cell lymphomas of mucosa-associated tissue (MALT lymphomas) constitute a group of low-grade non-Hodgkin's lymphomas that share an indolent clinical course and unique pathologic and molecular features. They arise in the context of chronic lymphoid proliferation in a wide variety of mucosal sites. The majority of MALT lymphomas are found in the stomach (70%); other tumor sites include the lung (14%), ocular adnexa (12%), thyroid (4%), and small intestine (1%).

MALT lymphomas were first recognized as a discrete entity in 1994 by the Revised European-American Lymphoma (REAL) classification. In the more recent WHO classification system, MALT lymphomas are grouped with splenic and nodal marginal-zone lymphomas based on the normal cell counterpart that these three B-cell neoplasms have in common (the marginal-zone B cell), despite the fact that they are morphologically, phenotypically, and genotypically distinct disease entities. Nodal and extranodal...


Pylorus Infection Malt Lymphoma Eradication Therapy Lymphoid Follicle Allelic Imbalance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Anne Müller
    • 1
  1. 1.Institute of Molecular Cancer Research (Institut für Molekulare Krebsforschung)University of ZurichZurichSwitzerland

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