Skip to main content
SpringerLink
Log in

Future Prospects for Helicobacter pylori Vaccination

  • Chapter
The Biology of Gastric Cancers

  • 766 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Aebischer, T., Bumann, D., Epple, H. D., Graham, D. Y., Metzger, W., Schneider, T., Stolte, M., Zeitz, M., and Meyer, T. F. (2005). Development of a vaccine against Helicobacter pylori [abstract]. Helicobacter. 10:547.

    Google Scholar 

  • Aebischer, T., Laforsch, S., Hurwitz, R., Brombacher, F., and Meyer, T. F. (2001). Immunity against Helicobacter pylori: significance of interleukin-4 receptor alpha chain status and gender of infected mice. Infect Immun. 69:556–558.

    Article  CAS  PubMed  Google Scholar 

  • Akhiani, A. A., Schon, K., Franzen, L. E., Pappo, J., and Lycke, N. (2004). Helicobacter pylori-specific antibodies impair the development of gastritis, facilitate bacterial colonization, and counteract resistance against infection. J Immunol. 172:5024–5033.

    CAS  PubMed  Google Scholar 

  • Akhiani, A. A., Stensson, A., Schon, K., and Lycke, N. (2006). The nontoxic CTA1-DD adjuvant enhances protective immunity against Helicobacter pylori infection following mucosal immunization. Scand J Immunol. 63:97–105.

    Article  CAS  PubMed  Google Scholar 

  • Angelakopoulos, H., and Hohmann, E. L. (2000). Pilot study of phoP/phoQ-deleted Salmonella enterica serovar typhimurium expressing Helicobacter pylori urease in adult volunteers. Infect Immun. 68:2135–2141.

    Article  CAS  PubMed  Google Scholar 

  • Banerjee, S., Medina-Fatimi, A., Nichols, R., Tendler, D., Michetti, M., Simon, J., Kelly, C. P., Monath, T. P., and Michetti, P. (2002). Safety and efficacy of low dose Escherichia coli enter-otoxin adjuvant for urease based oral immunisation against Helicobacter pylori in healthy volunteers. Gut. 51:634–640.

    Article  CAS  PubMed  Google Scholar 

  • Belkaid, Y., Blank, R. B., and Suffia I. (2006). Natural regulatory T cells and parasites: a common quest for host homeostasis. Immunol Rev. 212:287–300.

    Article  CAS  PubMed  Google Scholar 

  • Boncristiano, M., Paccani, S. R., Barone, S., Ulivieri, C., Patrussi, L., Ilver, D., Amedei, A., D'Elios, M. M., Telford, J. L., and Baldari, C. T. (2003). The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms. J Exp Med. 198:1887–1897.

    Article  CAS  PubMed  Google Scholar 

  • Brandtzaeg, P. (2007). Induction of secretory immunity and memory at mucosal surfaces. Vaccine. 25(30):5467–5484.

    Article  CAS  PubMed  Google Scholar 

  • Bumann, D., Metzger, W. G., Mansouri, E., Palme, O., Wendland, M., Hurwitz, R., Haas, G., Aebischer, T., von Specht, B. U., and Meyer, T. F. (2001). Safety and immunogenicity of live recombinant Salmonella enterica serovar Typhi Ty21a expressing urease A and B from Helicobacter pylori in human volunteers. Vaccine. 20:845–852.

    Article  CAS  PubMed  Google Scholar 

  • Corthesy, B., Boris, S., Isler, P., Grangette, C., and Mercenier, A. (2005). Oral immunization of mice with lactic acid bacteria producing Helicobacter pylori urease B subunit partially protects against challenge with Helicobacter felis. J Infect Dis. 192:1441–1449.

    Article  CAS  PubMed  Google Scholar 

  • Corthesy-Theulaz, I. E., Hopkins, S., Bachmann, D., Saldinger, P. F., Porta, N., Haas, R., Zheng-Xin, Y., Meyer, T., Bouzourene, H., Blum, A. L., and Kraehenbuhl, J. P. (1998). Mice are protected from Helicobacter pylori infection by nasal immunization with attenuated Salmonella typhimurium phoPc expressing urease A and B subunits. Infect Immun. 66:581–586.

    CAS  PubMed  Google Scholar 

  • Corthesy-Theulaz, I., Porta, N., Glauser, M., Saraga, E., Vaney, A. C., Haas, R., Kraehenbuhl, J. P., Blum, A. L., and Michetti, P. (1995). Oral immunization with Helicobacter pylori urease B subunit as a treatment against Helicobacter infection in mice. Gastroenterology. 109:115–21.

    Article  CAS  PubMed  Google Scholar 

  • Cryz, S. J. (1993). Post-marketing experience with live oral Ty21a vaccine. Lancet. 341:49–50.

    Article  PubMed  Google Scholar 

  • Czinn, S. J., Cai, A., and Nedrud, J. G. (1993). Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization. Vaccine. 11:637–642.

    Article  CAS  PubMed  Google Scholar 

  • Del Giudice, G., Covacci, A., Telford, J. L., Montecucco, C., and Rappuoli, R. (2001). The design of vaccines against Helicobacter pylori and their development. Annu Rev Immunol. 19:523–563.

    Article  PubMed  Google Scholar 

  • DiPetrillo, M. D., Tibbetts, T., Kleanthous, H., Killeen, K. P., and Hohmann, E. L. (1999). Safety and immunogenicity of phoP/phoQ-deleted Salmonella typhi expressing Helicobacter pylori urease in adult volunteers. Vaccine. 18:449–459.

    Article  CAS  PubMed  Google Scholar 

  • Di Tommaso, A., Xiang, Z., Bugnoli, M., Pileri, P., Figura, N., Bayeli, P. F., Rappuoli, R., Abrignani, S., and De Magistris, M. T. (1995). Helicobacter pylori-specific CD4+ T-cell clones from peripheral blood and gastric biopsies. Infect Immun. 63:1102–1106.

    PubMed  Google Scholar 

  • Dixon, M. F., Genta, R. M., Yardley, J. H., and Correa, P. (1996). Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol. 20:1161–1181.

    Article  CAS  PubMed  Google Scholar 

  • Doidge, C., Crust, I., Lee, A., Buck, F., Hazell, S., and Manne, U. (1994). Therapeutic immunisation against Helicobacter infection. Lancet. 343:914–915.

    Article  CAS  PubMed  Google Scholar 

  • Dubois, A., Fiala, N., Heman-Ackah, L. M., Drazek, E. S., Tarnawski, A., Fishbein, W. N., Perez-Perez, G. I., and Blaser, M.J. (1994). Natural gastric infection with Helicobacter pylori in monkeys: a model for spiral bacteria infection in humans. Gastroenterology. 106:1405–1417.

    CAS  PubMed  Google Scholar 

  • Dunkley, M. L., Harris, S. J., McCoy, R. J., Musicka, M. J., Eyers, F. M., Beagley, L. G., Lumley, P. J., Beagley, K. W., and Clancy, R. L. (1999). Protection against Helicobacter pylori infection by intestinal immunisation with a 50/52-kDa subunit protein. FEMS Immunol Med Microbiol. 24:221–225.

    Article  CAS  PubMed  Google Scholar 

  • Eaton, K. A., and Krakowka S. (1994). Effect of gastric pH on urease-dependent colonization of gnotobiotic piglets by Helicobacter pylori. Infect Immun. 62:3604–3607.

    CAS  PubMed  Google Scholar 

  • Eaton, K. A., Suerbaum, S., Josenhans, C., and Krakowka, S. (1996). Colonization of gnotobiotic piglets by Helicobacter pylori deficient in two flagellin genes. Infect Immun. 64:2445–2448.

    CAS  PubMed  Google Scholar 

  • Ermak, T. H., Giannasca, P. J., Nichols, R., Myers, G. A., Nedrud, J., Weltzin, R., Lee, C. K., Kleanthous, H., and Monath, T. P. (1998). Immunization of mice with urease vaccine affords protection against Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class II-restricted responses. J Exp Med. 188:2277–2288.

    Article  CAS  PubMed  Google Scholar 

  • Ernst, P. B., and Gold, B. D. (2000). The disease spectrum of Helicobacter pylori: the immunopathogenesis of gastroduodenal ulcer and gastric cancer. Ann Rev Microbiol. 54:615–640.

    Article  CAS  Google Scholar 

  • Feldman, R. A. (2001). Epidemiologic observations and open questions about disease and infection caused by Helicobacter pylori. In: Achtman, M., and Suerbaum, S., editors. Helicobacter pylori: molecular and cellular biology. Wymondham: Horizon Scientific Press; pp. 29–51.

    Google Scholar 

  • Ferrero, R. L., and Labigne, A. (1993). Cloning, expression and sequencing of Helicobacter felis urease genes. Mol Microbiol. 9:323–333.

    Article  CAS  PubMed  Google Scholar 

  • Ferrero, R. L., Thiberge, J. M., Kansau, I., Wuscher, N., Huerre, M., and Labigne, A. (1995). The GroES homolog of Helicobacter pylori confers protective immunity against mucosal infection in mice. Proc Natl Acad Sci USA. 92:6499–6503.

    Article  CAS  PubMed  Google Scholar 

  • Garhart, C. A., Redline, R. W., Nedrud, J. G., and Czinn, S. J. (2002). Clearance of Helicobacter pylori infection and resolution of postimmunization gastritis in a kinetic study of prophylactically immunized mice. Infect Immun. 70:3529–3538.

    Article  CAS  PubMed  Google Scholar 

  • Gebert, B., Fischer, W., Weiss, E., Hoffmann, R., and Haas, R. (2003). Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation. Science. 301:1099–1102.

    Article  CAS  PubMed  Google Scholar 

  • Gewirtz, A. T., Yu, Y., Krishna, U. S., Israel, D. A., Lyons, S. L., and Peek, R. M. (2004). Helicobacter pylori flagellin evades Toll-like receptor 5-mediated innate immunity. J Infect Dis 189:1914–1920.

    Article  CAS  PubMed  Google Scholar 

  • Ghendon, Y., and Robertson, S. E. (1994). Interrupting the transmission of wild polioviruses with vaccines: immunological considerations. Bull World Health Organ. 72:973–983.

    CAS  PubMed  Google Scholar 

  • Ghiara, P., Marchetti, M., Blaser, M. J., Tummuru, M. K., Cover, T. L., Segal, E. D., Tompkins, L. S., and Rappuoli, R. (1995). Role of the Helicobacter pylori virulence factors vacuolating cytotoxin, CagA, and urease in a mouse model of disease. Infect Immun. 63:4154–4160.

    CAS  PubMed  Google Scholar 

  • Ghiara, P., Rossi, M., Marchetti, M., Di Tommaso, A., Vindigni, C., Ciampolini, F., Covacci, A., Telford, J. L., De Magistris, M. T., Pizza, M., Rappuoli, R., and Del Giudice, G. (1997). Therapeutic intragastric vaccination against Helicobacter pylori in mice eradicates an otherwise chronic infection and confers protection against reinfection. Infect Immun. 65:4996–5002.

    CAS  PubMed  Google Scholar 

  • Gluck, R., Mischler, R., Durrer, P., Furer, E., Lang, A. B., Herzog, C., and Cryz, S. J. (2000). Safety and immunogenicity of intranasally administered inactivated trivalent virosome-formulated influenza vaccine containing Escherichia coli heat-labile toxin as a mucosal adjuvant. J Infect Dis. 181:1129–1132.

    Article  CAS  PubMed  Google Scholar 

  • Goodman, K. J., Correa, P., Tengana Aux, H. J., Ramirez, H., DeLany, J. P., Guerrero, P. O., Lopez, Q. M., and Collazos, P. T. (1996). Helicobacter pylori infection in the Colombian Andes: a population-based study of transmission pathways. Am J Epidemiol. 144:290–299.

    CAS  PubMed  Google Scholar 

  • Gomez-Duarte, O. G., Lucas, B., Yan, Z. X., Panthel, K., Haas, R., and Meyer, T. F. (1998). Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and B. Vaccine. 16:460–471.

    Article  CAS  PubMed  Google Scholar 

  • Gottwein, J. M., Blanchard, T. G., Targoni, O. S., Eisenberg, J. C., Zagorski, B. M., Redline, R. W., Nedrud, J. G., Tary-Lehmann, M., Lehmann, P. V., and Czinn, S. J. (2001). Protective anti-Helicobacter immunity is induced with aluminum hydroxide or complete Freund's adjuvant by systemic immunization. J Infect Dis. 184:308–314.

    Article  CAS  PubMed  Google Scholar 

  • Graham, D. Y., Opekun, A. R., Osato, M. S., El-Zimaity, H. M., Lee, C. K., Yamaoka, Y., Qureshi, W. A., Cadoz, M., and Monath, T. P. (2004). Challenge model for Helicobacter pylori infection in human volunteers. Gut. 53:1235–1243.

    Article  CAS  PubMed  Google Scholar 

  • Guruge, J. L., Falk, P. G., Lorenz, R. G., Dans, M., Wirth, H. P., Blaser, M. J., Berg, D. E., and Gordon, J. I. (1998). Epithelial attachment alters the outcome of Helicobacter pylori infection. Proc Natl Acad Sci USA. 95:3925–3930.

    Article  CAS  PubMed  Google Scholar 

  • Hatzifoti, C., Roussel, Y., Harris, A. G., Wren, B. W., Morrow, J. W., and Bajaj-Elliott, M. (20066). Mucosal immunization with a urease B DNA vaccine induces innate and cellular immune responses against Helicobacter pylori. Helicobacter. 11:113–122.

    Article  CAS  Google Scholar 

  • Hayashi, S., Sugiyama, T., Yokota, K., Isogai, H., Isogai, E., Oguma, K., Asaka, M., Fujii, N., and Hirai, Y. (1998). Analysis of immunoglobulin A antibodies to Helicobacter pylori in serum and gastric juice in relation to mucosal inflammation. Clin Diagn Lab Immunol. 5:617–621.

    CAS  PubMed  Google Scholar 

  • Hazell, S. L., Lee, A., Brady, L., and Hennessy, W. (1986). Campylobacter pyloridis and gastritis: association with intercellular spaces and adaptation to an environment of mucus as important factors in colonization of the gastric epithelium. J Infect Dis. 153:658–663.

    CAS  PubMed  Google Scholar 

  • Ikewaki, J., Nishizono, A., Goto, T., Fujioka, T., and Mifune, K. (2000). Therapeutic oral vaccination induces mucosal immune response sufficient to eliminate long-term Helicobacter pylori infection. Microbiol Immunol. 44:29–39.

    CAS  PubMed  Google Scholar 

  • Ismail, H. F., Fick, P., Zhang, J., Lynch, R. G., and Berg, D. J. (2003a). Depletion of neutrophils in IL-10(−/−) mice delays clearance of gastric Helicobacter infection and decreases the Th1 immune response to Helicobacter. J Immunol. 170:3782–3789.

    CAS  Google Scholar 

  • Ismail, H. F., Zhang, J., Lynch, R. G., Wang, Y., and Berg, D. J. (2003b). Role for complement in development of Helicobacter-induced gastritis in interleukin-10-deficient mice. Infect Immun. 71:7140–7148.

    Article  CAS  Google Scholar 

  • Kabir, S. (2007). The current status of Helicobacter pylori vaccines: a review. Helicobacter. 12:89–102.

    Article  CAS  PubMed  Google Scholar 

  • Kang, Q. Z., Duan, G. C., Fan, Q. T., and Xi, Y. L. (2005). Fusion expression of Helicobacter pylori neutrophil-activating protein in E. coli. World J Gastroenterol. 11:454–456.

    CAS  PubMed  Google Scholar 

  • Keenan, J., Oliaro, J., Domigan, N., Potter, H., Aitken, G., Allardyce, R., and Roake, J. (2000). Immune response to an 18-kilodalton outer membrane antigen identifies lipoprotein 20 as a Helicobacter pylori vaccine candidate. Infect Immun. 68:3337–3343.

    Article  CAS  PubMed  Google Scholar 

  • Kim, B. O., Shin, S. S., Yoo, Y. H., and Pyo, S. (2001). Peroral immunization with Helicobacter pylori adhesin protein genetically linked to cholera toxin A2B subunits. Clin Sci (Lond). 100:291–298.

    Article  CAS  Google Scholar 

  • Kotloff, K. L., Sztein, M. B., Wasserman, S. S., Losonsky, G. A., DiLorenzo, S. C., and Walker, R.I. (2001). Safety and immunogenicity of oral inactivated whole-cell Helicobacter pylori vaccine with adjuvant among volunteers with or without subclinical infection. Infect Immun. 69:3581–3590.

    Article  CAS  PubMed  Google Scholar 

  • Kreiss, C., Buclin, T., Cosma, M., and Michetti, P. (1996). Safety of oral immunization with recombinant urease in patients with Helicobacter pylori infection. Lancet. 347:1630–1631.

    Article  CAS  PubMed  Google Scholar 

  • Lee, A., Fox, J. G., Otto, G., and Murphy, J. (1990). A small animal model of human Helicobacter pylori active chronic gastritis. Gastroenterology. 99:1315–1323.

    CAS  PubMed  Google Scholar 

  • Lee, A., O'Rourke, J., De Ungria, M. C., Robertson, B., Daskalopoulos, G., and Dixon, M. F. (1997). A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain. Gastroenterology. 112:1386–1397.

    Article  CAS  PubMed  Google Scholar 

  • Lee, C. K., Soike, K., Giannasca, P., Hill, J., Weltzin, R., Kleanthous, H., Blanchard, J., and Monath, T. P. (1999a). Immunization of rhesus monkeys with a mucosal prime, parenteral boost strategy protects against infection with Helicobacter pylori. Vaccine. 17:3072–3082.

    Article  CAS  Google Scholar 

  • Lee, C. K., Soike, K., Hill, J., Georgakopoulos, K., Tibbitts, T., Ingrassia, J., Gray, H., Boden, J., Kleanthous, H., Giannasca, P., Ermak, T., Weltzin, R., Blanchard, J., and Monath, T. P. (1999b). Immunization with recombinant Helicobacter pylori urease decreases colonization levels following experimental infection of rhesus monkeys. Vaccine. 17:1493–1505.

    Article  CAS  Google Scholar 

  • Lee, C. K., Weltzin, R., Thomas, W., Jr., Kleanthous, H., Ermak, T. H., Soman, G., Hill, J. E., Ackerman, S. K., and Monath, T. P. (1995). Oral immunization with recombinant Helicobacter pylori urease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis. J Infect Dis. 172:161–172.

    CAS  PubMed  Google Scholar 

  • Levine, M. M., Kaper, J. B., Black, R. E., and Clements, M. L. (1983). New knowledge on pathogenesis of bacterial enteric infections as applied to vaccine development. Microbiol Rev. 47:510–550.

    CAS  PubMed  Google Scholar 

  • Lindholm, C., Quiding-Jarbrink, M., Lonroth, H., Hamlet, A., and Svennerholm, A. M. (1998). Local cytokine response in Helicobacter pylori-infected subjects. Infect Immun. 66: 5964–5971.

    CAS  PubMed  Google Scholar 

  • Losonsky, G. A., Kotloff, K. L., and Walker, R. I. (2003). B cell responses in gastric antrum and duodenum following oral inactivated Helicobacter pylori whole cell (HWC) vaccine and LT(R192G) in H pylori seronegative individuals. Vaccine. 21:562–565.

    Article  CAS  PubMed  Google Scholar 

  • Lundgren, A., Stromberg, E., Sjoling, A., Lindholm, C., Enarsson, K., Edebo, A., Johnsson, E., Suri-Payer, E., Larsson, P., Rudin, A., Svennerholm, A. M., and Lundin, B. S. (2005). Mucosal FOXP3-expressing CD4+ CD25high regulatory T cells in Helicobacter pylori-infected patients. Infect Immun. 73:523–531.

    Article  CAS  PubMed  Google Scholar 

  • Lundgren, A., Suri-Payer, E., Enarsson, K., Svennerholm, A. M., and Lundin, B. S. (2003). Helicobacter pylori-specific CD4+ CD25high regulatory T cells suppress memory T-cell responses to H. pylori in infected individuals. Infect Immun. 71:1755–1762.

    Article  CAS  PubMed  Google Scholar 

  • Malfertheiner, P., Megraud, F., O'morain, C., Bazzoli, F., El-Omar, E., Graham, D., Hunt, R., Rokkas, T., Vakil, N., and Kuipers, E. J. (2007). Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report. Gut. 56:772–781.

    Article  CAS  PubMed  Google Scholar 

  • Malfertheiner, P., Schultze, V., Del Giudice, G., Rosenkranz, B., Kaufmann, S. H. E.,. Winau, F, Ulrichs, T., Theophil, E., Jue, C. P., Novicki, D., Norelli, F., Contorni, M., Berti, D., Lin, J. S., Schwenke, C., Goldman, M., Tornese, D., Ganju, J., Palla, E., Rappuoli, R., and Scharschmidt, B. (2002). Phase I safety and immunogenicity of a three-component H. pylori vaccine. Gastroenterology 122 Suppl A-585, Abstr. W1195.

    Google Scholar 

  • Marchetti, M., Arico, B., Burroni, D., Figura, N., Rappuoli, R., and Ghiara P. (1995). Development of a mouse model of Helicobacter pylori infection that mimics human disease. Science. 267:1655–1658.

    Article  CAS  PubMed  Google Scholar 

  • Marchetti, M., Rossi, M., Giannelli, V., Giuliani, M. M., Pizza, M., Censini, S., Covacci, A., Massari, P., Pagliaccia, C., Manetti, R., Telford, J. L., Douce, G., Dougan, G., Rappuoli, R., and Ghiara, P. (1998). Protection against Helicobacter pylori infection in mice by intragastric vaccination with H. pylori antigens is achieved using a non-toxic mutant of E. coli heat-labile enterotoxin (LT) as adjuvant. Vaccine. 16:33–37.

    Article  CAS  PubMed  Google Scholar 

  • Marshall, B., and Warren, J. R. (1984). Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 323:1311–1315.

    Article  Google Scholar 

  • Mattsson, A., Quiding-Jarbrink, M., Lonroth, H., Hamlet, A., Ahlstedt, I., and Svennerholm, A. (1998). Antibody-secreting cells in the stomachs of symptomatic and asymptomatic Helicobacter pylori-infected subjects. Infect Immun. 66:2705–2712.

    CAS  PubMed  Google Scholar 

  • McAtee, C. P., Lim, M. Y., Fung, K., Velligan, M., Fry, K., Chow, T., and Berg, D. E. (1998). Identification of potential diagnostic and vaccine candidates of Helicobacter pylori by two-dimensional gel electrophoresis, sequence analysis, and serum profiling. Clin Diagn Lab Immunol. 5:537–542.

    CAS  PubMed  Google Scholar 

  • Megraud, F. (2004). H pylori antibiotic resistance prevalence, importance, and advances in testing. Gut. 53:1374–1384.

    Article  CAS  PubMed  Google Scholar 

  • Metzger, W. G., Mansouri, E., Kronawitter, M., Diescher, S., Soerensen, M., Hurwitz, R., Bumann, D., Aebischer, T., Von Specht, B. U., and Meyer, T. F. (2004). Impact of vector-priming on the immunogenicity of a live recombinant Salmonella enterica serovar typhi Ty21a vaccine expressing urease A and B from Helicobacter pylori in human volunteers. Vaccine. 22:2273–2277.

    Article  CAS  PubMed  Google Scholar 

  • Michetti, P., Corthesy-Theulaz, I., Davin, C., Haas, R., Vaney, A. C., Heitz, M., Bille, J., Kraehenbuhl, J. P., Saraga, E., and Blum, A. L. (1994). Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease. Gastroenterology. 107:1002–1011.

    CAS  PubMed  Google Scholar 

  • Michetti, M., Kelly, C. P., Kraehenbuhl, J. P., Bouzourene, H., and Michetti, P. (2000). Gastric mucosal alpha(4)beta(7)-integrin-positive CD4 T lymphocytes and immune protection against Helicobacter infection in mice. Gastroenterology. 119:109–118.

    Article  CAS  PubMed  Google Scholar 

  • Michetti, P., Kreiss, C., Kotloff, K. L., Porta, N., Blanco, J. L., Bachmann, D., Herranz, M., Saldinger, P. F., Corthesy-Theulaz, I., Losonsky, G., Nichols, R., Simon, J., Stolte, M., Ackerman, S., Monath, T. P., and Blum, A. L. (1999). Oral immunization with urease and Escherichia coli heat-labile enterotoxin is safe and immunogenic in Helicobacter pylori-infected adults. Gastroenterology. 116:804–812.

    Article  CAS  PubMed  Google Scholar 

  • Miyashita, M., Joh, T., Watanabe, K., Todoroki, I., Seno, K., Ohara, H., Nomura, T., Miyata, M., Kasugai, K., Tochikubo, K., Itoh, M., and Nitta, M. (2002). Immune responses in mice to intranasal and intracutaneous administration of a DNA vaccine encoding Helicobacter pylori-catalase. Vaccine. 20:2336–2342.

    Article  CAS  PubMed  Google Scholar 

  • Moschos, S. A., Bramwell, V. W., Somavarapu, S., and Alpar, H. O. (2004). Adjuvant synergy: the effects of nasal coadministration of adjuvants. Immunol Cell Biol. 82:628–637.

    Article  CAS  PubMed  Google Scholar 

  • Mutsch, M., Zhou, W., Rhodes, P., Bopp, M., Chen, R. T., Linder, T., Spyr, C., and Steffen, R. (2004). Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in Switzerland. N Engl J Med. 350:896–903.

    Article  CAS  PubMed  Google Scholar 

  • Nervi, G., Liatopoulou, S., Cavallaro, L. G., Gnocchi, A., Dal-Bo, N., Rugge, M., Iori, V., Cavestro, G. M., Maino, M., Colla, G., Franze, A., and Di Mario. F. (2006). Does Helicobacter pylori infection eradication modify peptic ulcer prevalence? A 10 years' endoscopical survey. World J Gastroenterol. 12:2398–2401.

    PubMed  Google Scholar 

  • Nurgalieva, Z. Z., Conner, M. E., Opekun, A. R., Zheng, C. Q., Elliott, S. N., Ernst, P. B., Osato, M., Estes, M. K., and Graham, D. Y. (2005). B-cell and T-cell immune responses to experimental Helicobacter pylori infection in humans. Infect Immun. 73:2999–3006.

    Article  CAS  PubMed  Google Scholar 

  • Pappo, J., Torrey, D., Castriotta, L., Savinainen, A., Kabok, Z., and Ibraghimov, A. (1999). Helicobacter pylori infection in immunized mice lacking major histocompatibility complex class I and class II functions. Infect Immun. 67:337–341.

    CAS  PubMed  Google Scholar 

  • Parsonnet, J., Shmuely, H., and Haggerty, T. (1999). Fecal and oral shedding of Helicobacter pylori from healthy infected adults. JAMA. 282:2240–2245.

    Article  CAS  PubMed  Google Scholar 

  • Perez-Perez, G. I., Dworkin, B. M., Chodos, J. E., and Blaser, M. J. (1988). Campylobacter pylori antibodies in humans. Ann Intern Med. 109:11–17.

    CAS  PubMed  Google Scholar 

  • Radcliff, F. J., Hazell, S. L., Kolesnikow, T., Doidge, C., and Lee, A. (1997). Catalase, a novel antigen for Helicobacter pylori vaccination. Infect Immun. 65:4668–4674.

    CAS  PubMed  Google Scholar 

  • Raghavan, S., Fredriksson, M., Svennerholm, A. M., Holmgren, J., and Suri-Payer, E. (2003). Absence of CD4+CD25+ regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori-infected mice. Clin Exp Immunol. 132:393–400.

    Article  CAS  PubMed  Google Scholar 

  • Reiner, S. L. (2007). Development in motion: helper T cells at work. Cell. 129:33–36.

    Article  CAS  PubMed  Google Scholar 

  • Rowland, M., Kumar, D., Daly, L., O'Connor, P., Vaughan, D., and Drumm B. (1999). Low rates of Helicobacter pylori reinfection in children. Gastroenterology. 117:336–341.

    Article  CAS  PubMed  Google Scholar 

  • Rupnow, M. F., Shachter, R. D., Owens, D. K., and Parsonnet, J. (2001). Quantifying the population impact of a prophylactic Helicobacter pylori vaccine. Vaccine. 20:879–885.

    Article  CAS  PubMed  Google Scholar 

  • Satin, B., Del Giudice, G., Della Bianca, V., Dusi, S., Laudanna, C., Tonello, F., Kelleher, D., Rappuoli, R., Montecucco, C., and Rossi, F. (2000). The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor. J Exp Med. 191:1467–1476.

    Article  CAS  PubMed  Google Scholar 

  • Sawai, N., Kita, M., Kodama, T., Tanahashi, T., Yamaoka, Y., Tagawa, Y., Iwakura, Y., and Imanishi, J. (1999). Role of gamma interferon in Helicobacter pylori-induced gastric inflammatory responses in a mouse model. Infect Immun. 67:279–285.

    CAS  PubMed  Google Scholar 

  • Schreiber, S., Konradt, M., Groll, C., Scheid, P., Hanauer, G., Werling, H. O., Josenhans C., and Suerbaum, S. (2004). The spatial orientation of Helicobacter pylori in the gastric mucus. Proc Natl Acad Sci USA. 101:5024–5029.

    Article  CAS  PubMed  Google Scholar 

  • Semino-Mora, C., Doi, S. Q., Marty, A., Simko, V., Carlstedt, I., and Dubois, A. (2003). Intracellular and interstitial expression of Helicobacter pylori virulence genes in gastric precancerous intestinal metaplasia and adenocarcinoma. J Infect Dis. 187:1165–1177.

    Article  CAS  PubMed  Google Scholar 

  • Shi, T., Liu, W. Z., Gao, F., Shi, G. Y., and Xiao, S. D. (2005). Intranasal CpG-oligodeoxynucleotide is a potent adjuvant of vaccine against Helicobacter pylori, and T helper 1 type response and interferon-gamma correlate with the protection. Helicobacter. 10:71–79.

    Article  CAS  PubMed  Google Scholar 

  • Smythies, L. E., Novak, M. J., Waites, K. B., Lindsey, J. R., Morrow, C. D., and Smith, P. D. (2005). Poliovirus replicons encoding the B subunit of Helicobacter pylori urease protect mice against H. pylori infection. Vaccine. 23:901–909.

    Article  CAS  PubMed  Google Scholar 

  • Solnick, J. V., Canfield, D. R., Hansen, L. M., and Torabian, S. Z. (2000). Immunization with recombinant Helicobacter pylori urease in specific-pathogen-free rhesus monkeys (Macaca mulatta). Infect Immun. 68:2560–2565.

    Article  CAS  PubMed  Google Scholar 

  • Sougioultzis, S., Lee, C. K., Alsahli, M., Banerjee, S., Cadoz, M., Schrader, R., Guy, B., Bedford, P., Monath, T. P., Kelly, C. P., and Michetti, P. (2002). Safety and efficacy of E coli enterotoxin adjuvant for urease-based rectal immunization against Helicobacter pylori. Vaccine. 21:194–201.

    Article  CAS  PubMed  Google Scholar 

  • Strobel S. (2001). Immunity induced after a feed of antigen during early life: oral tolerance v. sensitisation. Proc Nutr Soc 60:437–442.

    Article  CAS  PubMed  Google Scholar 

  • Suda, Y., Kim, Y. M., Ogawa, T., Yasui, N., Hasegawa, Y., Kashihara, W., Shimoyama, T., Aoyama, K., Nagata, K., Tamura, T., and Kusumuto, S. (2001). Chemical structure and biological activity of a lipid A component from Helicobacter pylori strain 206. J Endotoxin Res. 7:95–104.

    CAS  PubMed  Google Scholar 

  • Suzuki, T., Kato, K., Ohara, S., Noguchi, K., Sekine, H., Nagura, H., and Shimosegawa, T. (2002). Localization of antigen-presenting cells in Helicobacter pylori-infected gastric mucosa. Pathol Int. 52:265–271.

    Article  PubMed  Google Scholar 

  • Terres, A. M., and Pajares, J. M. (1998). An increased number of follicles containing activated CD69+ helper T cells and proliferating CD71+ B cells are found in H. pylori-infected gastric mucosa. Am J Gastroenterol. 93:579–583.

    CAS  PubMed  Google Scholar 

  • Todoroki, I., Joh, T., Watanabe, K., Miyashita, M., Seno, K., Nomura, T., Ohara, H., Yokoyama, Y., Tochikubo, K., and Itoh, M. (2000). Suppressive effects of DNA vaccines encoding heat shock protein on Helicobacter pylori-induced gastritis in mice. Biochem Biophys Res Commun. 277:159–163.

    Article  CAS  PubMed  Google Scholar 

  • Uemura, N., Okamoto, S., Yamamoto, S., Matsumura, N., Yamaguchi, S., Yamakido, M., Taniyama, K., Sasaki, N., and Schlemper, R. J. (2001) Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 345:784–789.

    Article  CAS  PubMed  Google Scholar 

  • Velin, D., Bachmann, D., Bouzourene, H., and Michetti, P. (2005). Mast cells are critical mediators of vaccine-induced Helicobacter clearance in the mouse model. Gastroenterology. 129:142–155.

    Article  CAS  PubMed  Google Scholar 

  • Wolle, K., and Malfertheiner, P. (2007). Treatment of Helicobacter pylori. Best Pract Res Clin Gastroenterol. 21:315–324.

    Article  CAS  PubMed  Google Scholar 

  • Yamaguchi, H., Osaki, T., Kai, M., Taguchi, H., and Kamiya S. (2000). Immune response against a cross-reactive epitope on the heat shock protein 60 homologue of Helicobacter pylori. Infect Immun. 68:3448–3454.

    Article  CAS  PubMed  Google Scholar 

  • Zabaleta, J., McGee, D. J., Zea, A. H., Hernandez, C. P., Rodriguez, P. C., Sierra, R. A., Correa, P., and Ochoa, A.C. (2004). Helicobacter pylori arginase inhibits T cell proliferation and reduces the expression of the TCR zeta-chain (CD3zeta). J Immunol. 173:586–593.

    CAS  PubMed  Google Scholar 

  • Zucca, E., Bertoni, F., Roggero, E., Bosshard, G., Cazzaniga, G., Pedrinis, E., Biondi, A., and Cavalli, F. (1998). Molecular analysis of the progression from Helicobacter pylori-associated chronic gastritis to mucosa-associated lymphoid-tissue lymphoma of the stomach. N Engl J Med. 338:804–810.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Service de Gastro-entérologie et d'Hépatologie, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland

    Dominique Velin & Pierre Michetti

Authors
  1. Dominique Velin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pierre Michetti
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Digestive and Liver Diseases, Columbia University, New York, NY, USA

    Timothy C. Wang (Silberberg Professor of Medicine Chair) (Silberberg Professor of Medicine Chair)

  2. Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

    James G. Fox (Director, Professor) (Director, Professor)

  3. Immunity and Environment Murdoch Childrens Research Institute, Royal Melbourne Hospital Footscray, Melbourne, Australia

    Andrew S. Giraud (Professor and Research Theme Director Infection) (Professor and Research Theme Director Infection)

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer Science + Business Media, LLC

About this chapter

Cite this chapter

Velin, D., Michetti, P. (2009). Future Prospects for Helicobacter pylori Vaccination. In: Wang, T.C., Fox, J.G., Giraud, A.S. (eds) The Biology of Gastric Cancers. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69182-4_24

Download citation

Publish with us

Policies and ethics

Search

Navigation