Role of Bone Marrow—Derived Cells in Gastric Adenocarcinoma

  • JeanMarie Houghton
  • Timothy C. Wang

Cancer Stem Cell Hypothesis

The origin of gastric cancer has remained mysterious for many years. Waldeyer originally developed the idea that gastric cancer arose from gastric epithelial cells, and believed that almost any gastric epithelial cell could be converted to a cancer cell (Houghton et al. 2007). Our understanding of the origins of gastric cancer has undergone a considerable change in recent years, partly based on the evolving paradigm of cancer stem cells (CSCs). Although for many years physicians and scientists regarded tumors as generally homogeneous tissues, accumulating evidence supports the view that cancer is sustained by a subset of cells—cancer stem cells—that have the exclusive ability to renew and propagate a tumor.

The origin of the CSC hypothesis dates back to the discovery of the light microscope in the nineteenth century. During that time, it was recognized that tumors were composed of a heterogeneous mixture of cell types with varying levels of differentiation,...


Stem Cell Gastric Cancer Green Fluorescent Protein Cancer Stem Cell Adult Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • JeanMarie Houghton
    • 1
  • Timothy C. Wang
    • 2
  1. 1.Department of Medicine and Cancer BiologyUniversity of Massachusetts Medical SchoolWorcesterUSA
  2. 2.Division of Digestive and Liver DiseasesColumbia UniversityNew YorkUSA

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