Genetic Models of Gastric Cancer in the Mouse
This chapter concentrates on murine genetic models that mimic gastric adenocarci-noma development, the most common stomach cancer of humans, rather than gastric lymphoma, or endocrine (ECL) carcinoids for which only a handful of mouse models have been described. Epithelial tumors are much less common in mice than humans; in the former, extragastric lymphomas and sarcomas predominate (Rangarajan and Weinberg 2003). Therefore, for epithelial tumors of the mouse stomach to be a dominant phenotype, the gene defect is likely to be important, and by homology may also contribute to human gastric cancer pathogenesis.
To date, the vast majority of genetic models recapitulate some or all of the developmental stages associated with intestinal-type gastric adenocarcinoma development rather than the less common sporadic (diffuse) gastric cancer. Thus, stepwise progression beginning with gastritis, atrophy, intestinal metaplasia, spasmolytic polypeptide expressing metaplasia (SPEM),...
KeywordsGastric Cancer Gastric Mucosa Intestinal Metaplasia Parietal Cell Submucosal Invasion
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