Host Immunity in the Development of Gastric Preneoplasia

  • Peter B. Ernst
  • Mohammad S. Alam
  • Asima Bhattacharyya
  • Sheila E. Crowe


Correa proposed a sequence of events that were associated with the development of gastric cancer that included gastritis as one of the earliest phases of a multistep process (Correa and Houghton 2007) (Figure 17.1). With the identification of Helicobacter pylori, it quickly became apparent that infection caused the gastritis that subsequently led to gastric preneoplasia and the development of gastric cancer in a subset of infected subjects. Several important issues have emanated from these observations including the role of the host response in the persistence of H. pyloriinfection and, given the chronic nature of the infection and inflammation, the role of immune and inflammatory factors in the pathogenesis of gastric cancer itself. This chapter reviews the initial immunologic responses that lead to gastritis and explains the persistence of infection. The consequence of chronic inflammation on epithelial cell damage that may lead to gastric neoplasia is discussed in the...


Gastric Cancer Major Histocompatibility Complex Gastric Mucosa Pylorus Infection Host Response 
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Copyright information

© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Peter B. Ernst
    • 1
  • Mohammad S. Alam
    • 1
  • Asima Bhattacharyya
    • 1
  • Sheila E. Crowe
    • 1
  1. 1.Division of Gastroenterology and Hepatology, Department of MedicineUniversity of VirginiaCharlottesvilleUSA

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