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Host Immunity in the Development of Gastric Preneoplasia

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References

  • Akbari, O., G. J. Freeman, E. H. Meyer, E. A. Greenfield, T. T. Chang, A. H. Sharpe, G. Berry, R. H. DeKruyff, and D. T. Umetsu. 2002. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat Med 8(9):1024–1032.

    Article  CAS  PubMed  Google Scholar 

  • Appelmelk, B. J., I. Simoons-Smit, R. Negrini, A. P. Moran, G. O. Aspinall, J. G. Forte, T. De Vries, et al. 1996. Potential role of molecular mimicry between Helicobacter pylori lipopoly-saccharide and host Lewis blood group antigens in autoimmunity. Infect Immun 64:2031–2040.

    CAS  PubMed  Google Scholar 

  • Atherton, J. C., P. Cao, R. M. Peek, M. K. Tummuru, M. J. Blaser, and T. L. Cover. 1995. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 270:17771–17777.

    Article  CAS  PubMed  Google Scholar 

  • Bach, J. F. 2003. Regulatory T cells under scrutiny. Nat Rev Immunol 3(3):189–198.

    Article  PubMed  CAS  Google Scholar 

  • Baik, S.-C., H.-S. Youn, M.-H. Chung, W.-K. Lee, M.-J. Cho, G.-H. Ko, C.-K. Park, H. Kasai, and K.-H. Rhee. 1996. Increased oxidative DNA damage in Helicobacter pylori-infected human gastric mucosa. Cancer Res 56:1279–1282.

    CAS  PubMed  Google Scholar 

  • Bamford, K. B., X. J. Fan, S. E. Crowe, J. F. Leary, W. K. Gourley, G. K. Luthra, E. G. Brooks, et al. 1998. Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype. Gastroenterology 114:482–492.

    Article  CAS  PubMed  Google Scholar 

  • Bauer, M. K. A., M. Vogt, M. Los, J. Siegel, S. Weselborg, and K. Schulze-Osthoff. 1998. Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression. J Biol Chem 273:8048–8055.

    Article  CAS  PubMed  Google Scholar 

  • Bennett, M. W., J. O'Connell, G. C. O'sullivan, D. Roche, C. Brady, J. K. Collins, and F. Shanahan. 1999. Expression of Fas ligand by human gastric adenocarcinomas: a potential mechanism of immune escape in stomach cancer. Gut 44:156–162.

    Article  CAS  PubMed  Google Scholar 

  • Berg, D. J., N. Davidson, R. Kuhn, W. Muller, S. Menon, G. Holland, L. Thompson-Snipes, M. W. Leach, and D. Rennick. 1996. Enterocolitis and colon cancer in interleukin-10 deficient mice are associated with aberrant cytokine production and CD4+ Th1-like responses. J Clin Invest 98:1010–1020.

    Article  CAS  PubMed  Google Scholar 

  • Berstad, A. E., P. Brandtzaeg, R. Stave, and T. S. Halstensen. 1997. Epithelium related deposition of activated complement in Helicobacter pylori associated gastritis. Gut 40:196–203.

    CAS  PubMed  Google Scholar 

  • Beswick, E. J., S. Das, I. V. Pinchuk, P. Adegboyega, G. Suarez, Y. Yamaoka, and V. E. Reyes. 2005. Helicobacter pylori-induced IL-8 production by gastric epithelial cells up-regulates CD74 expression. J Immunol 175(1):171–176.

    CAS  PubMed  Google Scholar 

  • Beswick, E. J., I. V. Pinchuk, S. Das, D. W. Powell, and V. E. Reyes. 2007. B7-H1 expression on gastric epithelial cells after Helicobacter pylori exposure promotes the development of CD4+ CD25+ FoxP3+ regulatory T cells. Infect Immun 75(9):4334–4341.

    Article  CAS  PubMed  Google Scholar 

  • Blaser, M. J. 2005. The biology of cag in the Helicobacter pylori-human interaction. Gastroenterology 128(5):1512–1515.

    Article  PubMed  CAS  Google Scholar 

  • Bliss, C. M., Jr., D. T. Golenblock, S. Keates, J. K. Linevsky, and C. P. Kelly. 1998. Helicobacter pylori lipopolysaccharide binds to CD14 and stimulates release of interleukin-8, epithelial neutrophil-activating peptide 78, and monocyte chemotactic protein 1 by human monocytes. Infect Immun 66:5357–5363.

    CAS  PubMed  Google Scholar 

  • Bluestone, J. A. and A. K. Abbas. 2003. Natural versus adaptive regulatory T cells. Nat Rev Immunol 3(3):253–257.

    Article  CAS  PubMed  Google Scholar 

  • Bour-Jordan, H., B. L. Salomon, H. L. Thompson, G. L. Szot, M. R. Bernhard, and J. A. Bluestone. 2004. Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells. J Clin Invest 114(7):979–987.

    CAS  PubMed  Google Scholar 

  • Brenes, F., B. Ruiz, P. Correa, F. Hunter, T. Rhamakrishnan, E. Fontham, and T.-Y. Shi. 1993. Helicobacter pylori causes hyperproliferation of the gastric epithelium: pre- and post-eradication indices of proliferating cell nuclear antigen. Am J Gastroenterol 88:1870–1875.

    CAS  PubMed  Google Scholar 

  • Chen, W., W. Jin, N. Hardegen, K. J. Lei, L. Li, N. Marinos, G. McGrady, and S. M. Wahl. 2003. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198(12):1875–1886.

    Article  CAS  PubMed  Google Scholar 

  • Claeys, D., G. Faller, B. J. Appelmelk, R. Negrini, and T. Kirchner. 1998. The gastric H+ K+-ATPase is a major autoantigen in chronic Helicobacter pylori gastritis with body mucosa atrophy. Gastroenterology 115:340–347.

    Article  CAS  PubMed  Google Scholar 

  • Clyne, M., P. Dillon, S. Daly, R. O'Kennedy, F. E. May, B. R. Westley, and B. Drumm. 2004. Helicobacter pylori interacts with the human single-domain trefoil protein TFF1. Proc Natl Acad Sci USA 101(19):7409–7414.

    Article  CAS  PubMed  Google Scholar 

  • Cong, Y., A. Konrad, N. Iqbal, R. D. Hatton, C. T. Weaver, and C. O. Elson. 2005. Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function. J Immunol 174(5):2787–2795.

    CAS  PubMed  Google Scholar 

  • Cong, Y., C. T. Weaver, A. Lazenby, and C. O. Elson. 2002. Bacterial-reactive T regulatory cells inhibit pathogenic immune responses to the enteric flora. J Immunol 169(11):6112–6119.

    CAS  PubMed  Google Scholar 

  • Correa, P. and J. Houghton. 2007. Carcinogenesis of Helicobacter pylori. Gastroenterology 133(2):659–672.

    Article  CAS  PubMed  Google Scholar 

  • Cover, T. L., U. S. Krishna, D. A. Israel, and R. M. Peek, Jr. 2003. Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Cancer Res 63(5):951–957.

    CAS  PubMed  Google Scholar 

  • Davidson, T. S., R. J. DiPaolo, J. Andersson, and E. M. Shevach. 2007. Cutting edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells. J Immunol 178(7):4022–4026.

    CAS  PubMed  Google Scholar 

  • Davies, G. R., N. J. Simmonds, T. R. J. Stevens, M. T. Sheaff, N. Banatvala, I. F. Laurenson, D. R. Blake, and D. S. Rampton. 1994. Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. Gut 35:179–185.

    Article  CAS  PubMed  Google Scholar 

  • Day, Y. J., M. A. Marshall, L. Huang, M. J. McDuffie, M. D. Okusa, and J. Linden. 2004. Protection from ischemic liver injury by activation of A2A adenosine receptors during reper-fusion: inhibition of chemokine induction. Am J Physiol Gastrointest Liver Physiol 286(2): G285–G293.

    Article  CAS  PubMed  Google Scholar 

  • Deaglio, S., K. M. Dwyer, W. Gao, D. Friedman, A. Usheva, A. Erat, J. F. Chen, et al. 2007. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med 204(6):1257–1265.

    Article  CAS  PubMed  Google Scholar 

  • D'Elios, M. M., M. Manghetti, M. De Carli, F. Costa, C. T. Baldari, D. Burroni, J. Telford, S. Romagnani, and G. Del Prete. 1997. T helper 1 effector cells specific for Helicobacter pylori in gastric antrum of patients with peptic ulcer disease. J Immunol 158:962–967.

    CAS  Google Scholar 

  • Demple, B. and J. S. Sung. 2005. Molecular and biological roles of Ape1 protein in mammalian base excision repair. DNA Repair (Amst) 4(12):1442–1449.

    Article  CAS  Google Scholar 

  • Denning, T. L., Y. C. Wang, S. R. Patel, I. R. Williams, and B. Pulendran. 2007. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 8(10):1086–1094.

    Article  CAS  PubMed  Google Scholar 

  • Ding, S. Z., Y. Minohara, X. J. Fan, J. Wang, V. E. Reyes, J. Patel, B. Dirden-Kramer, et al. 2007. Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cells. Infect Immun 75(8):4030–4039.

    Article  CAS  PubMed  Google Scholar 

  • Ding, S. Z., A. M. O'Hara, T. L Denning, B. Dirden-Kramer, R. C. Mifflin, V. E. Reyes, K. A. Ryan, et al. 2004. Helicobacter pylori and H2O2 increases AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells. Gastroenterology 127:845–858.

    Article  CAS  PubMed  Google Scholar 

  • Duchmann, R., I. Kaiser, E. Hermann, W. Mayet, K. Ewe, and K. H. Meyer zum Buschenfelde. 1995. Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD). Clin Exp Immunol 102:445–447.

    Google Scholar 

  • El-Omar, E. M., C. S. Rabkin, M. D. Gammon, T. L. Vaughan, H. A. Risch, J. B. Schoenberg, J. L. Stanford, et al. 2003. Increased risk of noncardia gastric cancer associated with proinflam-matory cytokine gene polymorphisms. Gastroenterology 124(5):1193–1201.

    Article  CAS  PubMed  Google Scholar 

  • Elson, C. O. and Y. Cong. 2002. Understanding immune-microbial homeostasis in intestine. Immunol Res 26(1–3):87–94.

    Article  CAS  PubMed  Google Scholar 

  • Enarsson, K., A. Lundgren, B. Kindlund, M. Hermansson, G. Roncador, A. H. Banham, B. S. Lundin, and M. Quiding-Jarbrink. 2006. Function and recruitment of mucosal regulatory T cells in human chronic Helicobacter pylori infection and gastric adenocarcinoma. Clin Immunol 121(3):358–368.

    Article  CAS  PubMed  Google Scholar 

  • Ernst, P. B., D. A. Peura, and S. E. Crowe. 2006. The translation of Helicobacter pylori basic research to patient care. Gastroenterology 130(1):188–206.

    Article  CAS  PubMed  Google Scholar 

  • Evans, A. R., M. Limp-Foster, and M. R. Kelley. 2000. Going APE over ref-1. Mutat Res 461(2):83–108.

    CAS  PubMed  Google Scholar 

  • Fan, X. J., S. E. Crowe, S. Behar, H. Gunasena, G. Ye, H. Haeberle, N. Van Houten, et al. 1998. The effect of class II MHC expression on adherence of Helicobacter pylori and induction of apoptosis in gastric epithelial cells: a mechanism for Th1 cell-mediated damage. J Exp Med 187:1659–1669.

    Article  CAS  PubMed  Google Scholar 

  • Fan, X., H. Gunasena, Z. Cheng, R. Espejo, S. E. Crowe, P. B. Ernst, and V. E. Reyes. 2000. Helicobacter pylori urease binds to class II MHC on gastric epithelial cells and induces their apoptosis. J Immunol 165:1918–1924.

    CAS  PubMed  Google Scholar 

  • Farinati, F., R. Cardin, P. Degan, M. Rugge, F. D. Mario, P. Bonvicini, and R. Naccarato. 1998. Oxidative DNA damage accumulation in gastric carcinogenesis. Gut 42:351–356.

    Article  CAS  PubMed  Google Scholar 

  • Ferrero, R. L. 2005. Innate immune recognition of the extracellular mucosal pathogen, Helicobacter pylori. Mol Immunol 42(8):879–885.

    Article  CAS  PubMed  Google Scholar 

  • Fiorentino, D. F., A. Zlotnik, P. Vieira, T. R. Mosmann, M. Howard, K. W. Moore, and A. O'Garra. 1991. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol 146:3444–3451.

    CAS  PubMed  Google Scholar 

  • Gaiddon, C., N. C. Moorthy, and C. Prives. 1999. Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo. EMBO J 18:5609–5621.

    Article  CAS  PubMed  Google Scholar 

  • Guiney, D. G., P. Hasegawa, and S. P. Cole. 2003. Helicobacter pylori preferentially induces interleukin 12 (IL-12) rather than IL-6 or IL-10 in human dendritic cells. Infect Immun 71(7):4163–4166.

    Article  CAS  PubMed  Google Scholar 

  • Hall, J. L., X. Wang, Adamson Van, Y. Zhao, and G. H. Gibbons. 2001. Overexpression of Ref-1 inhibits hypoxia and tumor necrosis factor- induced endothelial cell apoptosis through nuclear factor-kappa b- independent and -dependent pathways. Circ Res 88(12):1247–1253.

    Article  CAS  PubMed  Google Scholar 

  • Harrington, L. E., R. D. Hatton, P. R. Mangan, H. Turner, T. L. Murphy, K. M. Murphy, and C. T. Weaver. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6(11):1123–1132.

    Article  CAS  PubMed  Google Scholar 

  • Harris, P. R., P. B. Ernst, S. Kawabata, H. Kiyono, M. F. Graham, and P. D. Smith. 1998. Recombinant Helicobacter pylori urease activates primary mucosal macrophages. J Infect Dis 178(5):1516–1520.

    Article  CAS  PubMed  Google Scholar 

  • Hasko, G. and B. N. Cronstein. 2004. Adenosine: an endogenous regulator of innate immunity. Trends Immunol 25(1):33–39.

    Article  CAS  PubMed  Google Scholar 

  • Hasko, G., D. G. Kuhel, J. F. Chen, M. A. Schwarzschild, E. A. Deitch, J. G. Mabley, A. Marton, and C. Szabo. 2000. Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanisms. FASEB J 14(13):2065–2074.

    Article  CAS  PubMed  Google Scholar 

  • Heneghan, M. A., C. F. McCarthy, D. Janulaityte, and A. P. Moran. 2001. Relationship of anti-Lewis x and anti-Lewis y antibodies in serum samples from gastric cancer and chronic gastritis patients to Helicobacter pylori-mediated autoimmunity. Infect Immun 69:4774–4781.

    Article  CAS  PubMed  Google Scholar 

  • Hetts, S. W. 1998. To die or not to die. An overview of apoptosis and its role in disease. JAMA 279:300–307.

    Article  CAS  PubMed  Google Scholar 

  • Huang, S., S. Apasov, M. Koshiba, and M. Sitkovsky. 1997. Role of A2a extracellular adenosine receptor-mediated signaling in adenosine-mediated inhibition of T-cell activation and expansion. Blood 90(4):1600–1610.

    CAS  PubMed  Google Scholar 

  • Ishikawa, Y., T. Yokoo, and M. Kiamura. 1997. c-Jun/AP-1, but not NF-kB, is a mediator for oxidant-initiated apoptosis in glomerular mesangial cells. Biochem Biophys Res Commun 240:496–501.

    Article  CAS  PubMed  Google Scholar 

  • Ismail, H. F., J. Zhang, R. G. Lynch, Y. Wang, and D. J. Berg. 2003. Role for complement in development of Helicobacter-induced gastritis in interleukin-10-deficient mice. Infect Immun 71(12):7140–7148.

    Article  CAS  PubMed  Google Scholar 

  • Izumi, T., W. D. Henner, and S. Mitra. 1996. Negative regulation of the major human AP-endonuclease, a multifunctional protein. Biochemistry 35:14679–14683.

    Article  CAS  PubMed  Google Scholar 

  • Izumi, T. and S. Mitra. 1998. Deletion analysis of human AP-endonuclease: minimum sequence required for the endonuclease activity. Carcinogenesis 19:525–527.

    Article  CAS  PubMed  Google Scholar 

  • Janssen, Y. M. W., B. Van Houten, P. J. A. Borm, and B. T. Mossman. 1993. Biology of Disease. Cell and tissue responses to oxidative damage. Lab Invest 69:261–274.

    CAS  PubMed  Google Scholar 

  • Jayaraman, L., K. G. K. Murthy, C. Zhu, T. Curran, S. Xanthoudakis, and C. Prives. 1997. Identification of redox/repair protein Ref-1 as a potent activator of p53. Genes Dev 11:558–570.

    Article  CAS  PubMed  Google Scholar 

  • Jones, N. L., P. T. Shannon, E. Cutz, H. Yeger, and P. M. Sherman. 1997. Increase in proliferation and apoptosis of gastric epithelial cells early in the natural history of Helicobacter pylori infection. Am J Pathol 151:1695–1703.

    CAS  PubMed  Google Scholar 

  • Jump, R. L. and A. D. Levine. 2002. Murine Peyer's patches favor development of an IL-10-secreting, regulatory T cell population. J Immunol 168(12):6113–6119.

    CAS  PubMed  Google Scholar 

  • Karin, M. 1998. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 270:16483–16486.

    Google Scholar 

  • Karttunen, R., T. Karttunen, H.-P. T. Ekre, and T. T. MacDonald. 1995. Interferon gamma and interleukin 4 secreting cells in the gastric antrum in Helicobacter pylori positive and negative gastritis. Gut 36:341–345.

    Article  CAS  PubMed  Google Scholar 

  • Kawahara, T., Y. Kuwano, S. Teshima-Kondo, T. Kawai, T. Nikawa, K. Kishi, and K. Rokutan. 2001. Toll-like receptor 4 regulates gastric pit cell responses to Helicobacter pylori infection. J Med Invest 48(3–4):190–197.

    CAS  PubMed  Google Scholar 

  • Keates, S., Y. S. Hitti, M. Upton, and C. P. Kelly. 1997. Helicobacter pylori infection activates NF-?B in gastric epithelial cells. Gastroenterology 113:1099–1109.

    Article  CAS  PubMed  Google Scholar 

  • Krajewska, M., C. M. Fenoglio-Preiser, S. Krajewski, K. Song, J. S. Macdonald, G. Stemmerman, and J. C. Reed. 1996. Immunohistochemical analysis of Bcl-2 family proteins in adenocarci-nomas of the stomach. Am J Pathol 149:1449–1457.

    CAS  PubMed  Google Scholar 

  • Kranzer, K., A. Eckhardt, M. Aigner, G. Knoll, L. Deml, C. Speth, N. Lehn, M. Rehli, and W. Schneider-Brachert. 2004. Induction of maturation and cytokine release of human dendritic cells by Helicobacter pylori. Infect Immun 72(8):4416–4423.

    Article  CAS  PubMed  Google Scholar 

  • Kullberg, M. C., D. Jankovic, P. L. Gorelick, P. Caspar, J. J. Letterio, A. W. Cheever, and A. Sher. 2002. Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis. J Exp Med 196(4):505–515.

    Article  CAS  PubMed  Google Scholar 

  • Kume, T., K. Oshima, Y. Yamashita, T. Shirakusa, and M. Kikuchi. 1999. Relationship between Fas-ligand expression on carcinoma cell and cytotoxic T-lymphocyte response in lymphoepi-thelioma-like cancer of the stomach. Int J Cancer 84:339–343.

    Article  CAS  PubMed  Google Scholar 

  • Kwok, T., D. Zabler, S. Urman, M. Rohde, R. Hartig, S. Wessler, R. Misselwitz, et al. 2007. Helicobacter exploits integrin for type IV secretion and kinase activation. Nature 449(7164):862–866.

    Article  CAS  PubMed  Google Scholar 

  • Lando, D., I. Pongratz, L. Poellinger, and M. L. Whitelaw. 2000. A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1a and the HIF-like factor. J Biol Chem 275:4618–4627.

    Article  CAS  PubMed  Google Scholar 

  • Lappas, C. M., J. M. Rieger, and J. Linden. 2005. A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cells. J Immunol 174(2):1073–1080.

    CAS  PubMed  Google Scholar 

  • Lefebvre, O., M. P. Chenard, R. Masson, J. Linares, A. Dierich, M. LeMeur, C. Wendling, et al. 1996. Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Science 274(5285):259–262.

    Article  CAS  PubMed  Google Scholar 

  • Linden, J. 2001. Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection. Annu Rev Pharmacol Toxicol 41:775–787.

    Article  CAS  PubMed  Google Scholar 

  • Lukashev, D., A. Ohta, S. Apasov, J. F. Chen, and M. Sitkovsky. 2004. Cutting edge: physiologic attenuation of proinflammatory transcription by the Gs protein-coupled A2A adenosine receptor in vivo. J Immunol 173(1):21–24.

    CAS  PubMed  Google Scholar 

  • Lundgren, A., E. Stromberg, A. Sjoling, C. Lindholm, K. Enarsson, A. Edebo, E. Johnsson, et al. 2005. Mucosal FOXP3-expressing CD4+ CD25high regulatory T cells in Helicobacter pylori-infected patients. Infect Immun 73(1):523–531.

    Article  CAS  PubMed  Google Scholar 

  • Luzza, F., T. Parrello, G. Monteleone, L. Sebkova, M. Romano, R. Zarrilli, M. Imeneo, and F. Pallone. 2000. Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa. J Immunol 165(9):5332–5337.

    CAS  PubMed  Google Scholar 

  • Lynch, D. A. F., N. P. Mapstone, A. M. T. Clarke, G. M. Sobala, P. Jackson, L. Morrison, M. F. Dixon, P. Quirke, and A. T. R. Axon. 1995. Cell proliferation in Helicobacter pylori associated gastritis and the effect of eradication therapy. Gut 36:346–350.

    Article  CAS  PubMed  Google Scholar 

  • Mabley, J. G., P. Pacher, L. Liaudet, F. G. Soriano, G. Hasko, A. Marton, C. Szabo, and A. L. Salzman. 2003. Inosine reduces inflammation and improves survival in a murine model of colitis. Am J Physiol Gastrointest Liver Physiol 284(1):G138–G144.

    CAS  PubMed  Google Scholar 

  • Maloy, K. J., L. Salaun, R. Cahill, G. Dougan, N. J. Saunders, and F. Powrie. 2003. CD4(+)CD25(+) T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med 197(1):111–119.

    Article  CAS  PubMed  Google Scholar 

  • Mandell, L., A. P. Moran, A. Cocchiarella, J. Houghton, N. Taylor, J. G. Fox, T. C. Wang, and E. A. Kurt-Jones. 2004. Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via toll-like receptor 2 but not toll -like receptor 4. Infect Immun 72(11):6446–6454.

    Article  CAS  PubMed  Google Scholar 

  • Mohammadi, M., J. Nedrud, R. Redline, N. Lycke, and S. J. Czinn. 1997. Murine CD4 T-cell response to Helicobacter infection: TH1 cells enhance gastritis and TH2 cells reduce bacterial load. Gastroenterology 113:1848–1857.

    Article  CAS  PubMed  Google Scholar 

  • Moss, S. F. 1998. Cellular markers in the gastric precancerous process. Aliment Pharmacol Ther 12(Suppl 1):91–109.

    Article  CAS  PubMed  Google Scholar 

  • Moss, S. F., J. Calam, B. Agarwal, S. Wang, and P. G. Holt. 1996. Induction of gastric epithelial apoptosis by Helicobacter pylori. Gut 38:498–501.

    Article  CAS  PubMed  Google Scholar 

  • Nagai, S., H. Mimuro, T. Yamada, Y. Baba, K. Moro, T. Nochi, H. Kiyono, et al. 2007. Role of Peyer's patches in the induction of Helicobacter pylori-induced gastritis. Proc Natl Acad Sci USA 104(21):8971–8976.

    Article  CAS  PubMed  Google Scholar 

  • Naganuma, M., E. B. Wiznerowicz, C. M. Lappas, J. Linden, M. T. Worthington, and P. B. Ernst. 2006. Cutting Edge: critical role for adenosine A2A receptors in the T cell mediated regulation of colitis. J Immunol 177:2765–2769.

    CAS  PubMed  Google Scholar 

  • Naumann, M., S. Wessler, C. Bartsch, B. Wieland, A. Covacci, R. Haas, and T. F. Meyer. 1999. Activation of activator protein 1 and stress response kinases in epithelial cells colonized by Helicobacter pylori encoding the cag pathogenicity island. J Biol Chem 274:31655–31662.

    Article  CAS  PubMed  Google Scholar 

  • Negrini, R., L. Lisato, I. Zanella, L. Cavazzini, S. Gullini, V. Villanacci, C. Poiesi, A. Albertini, and S. Ghielmi. 1991. Helicobacter pylori infection induces antibodies cross-reacting with human gastric mucosa. Gastroenterology 101:437–445.

    CAS  PubMed  Google Scholar 

  • Nishi, T., K. Okazaki, K. Kawasaki, T. Fukui, H. Tamaki, M. Matsuura, M. Asada, et al. 2003. Involvement of myeloid dendritic cells in the development of gastric secondary lymphoid fol licles in Helicobacter pylori-infected neonatally thymectomized BALB/c mice. Infect Immun 71(4):2153–2162.

    Article  CAS  PubMed  Google Scholar 

  • Obst, B., S. Wagner, K. F. Sewing, and W. Beil. 2000. Helicobacter pylori causes DNA damage in gastric epithelial cells. Carcinogenesis 21:1111–1115.

    Article  CAS  PubMed  Google Scholar 

  • Odashima, M., G. Bamias, J. Rivera-Nieves, J. Linden, C. C. Nast, C. A. Moskaluk, M. Marini, et al. 2005. Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease. Gastroenterology 129(1):26–33.

    Article  CAS  PubMed  Google Scholar 

  • O'Hara, A. M., A. Bhattacharya, J. Bai, R. C. Mifflin, M. F. Smith, Jr., K. A. Ryan, K. G-E. Scott, et al. 2006. Interleukin-8 induction by Helicobacter pylori in human gastric epithelial cells is dependent on apurinic/apyrimidinic endonuclease-1/redox factor-1. J Immunol 177:7990–7999.

    PubMed  Google Scholar 

  • Okusa, M. D., J. Linden, L. Huang, J. M. Rieger, T. L. Macdonald, and L. P. Huynh. 2000. A(2A) adenosine receptor-mediated inhibition of renal injury and neutrophil adhesion. Am J Physiol Renal Physiol 279(5):F809–F818.

    CAS  PubMed  Google Scholar 

  • Pacheco, R., J. M. Martinez-Navio, M. Lejeune, N. Climent, H. Oliva, J. M. Gatell, T. Gallart, et al. 2005. CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse. Proc Natl Acad Sci USA 102(27):9583–9588.

    Article  CAS  PubMed  Google Scholar 

  • Peek, R. M., Jr., M. J. Blaser, D. J. Mays, M. H. Forsyth, T. L. Cover, S. Y. Song, U. Krishna, and J. A. Pietenpol. 1999. Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle. Cancer Res 59:6124–6131.

    CAS  PubMed  Google Scholar 

  • Polyak, K., Y. Xia, J. L. Zweier, K. W. Kinzler, and B. Vogelstein. 1997. A model of p53-induced apoptosis. Nature 389:300–305.

    Article  CAS  PubMed  Google Scholar 

  • Quillet-Mary, A., J. P. Jaffrezou, V. Mansat, C. Bordier, J. Naval, and G. Laurent. 1997. Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis. J Biol Chem 272:21388–21395.

    Article  CAS  PubMed  Google Scholar 

  • Rad, R., L. Brenner, S. Bauer, S. Schwendy, L. Layland, C. P. da Costa, W. Reindl, et al. 2006. CD25+/Foxp3+ T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo. Gastroenterology 131(2):525–537.

    Article  CAS  PubMed  Google Scholar 

  • Rad, R., L. Brenner, A. Krug, P. Voland, J. Mages, R. Lang, S. Schwendy, et al. 2007. Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori. Gastroenterology 133(1):150–163.

    Article  CAS  PubMed  Google Scholar 

  • Raghavan, S. and J. Holmgren. 2005. CD4+CD25+ suppressor T cells regulate pathogen induced inflammation and disease. FEMS Immunol Med Microbiol 44(2):121–127.

    Article  CAS  PubMed  Google Scholar 

  • Ramana, C. V., I. Boldogh, T. Izumi, and S. Mitra. 1998. Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals. Proc Natl Acad Sci 95:5061–5065.

    Article  CAS  PubMed  Google Scholar 

  • Rudi, J., D. Kuck, S. Strand, A. Von Herbay, S. M. Mariani, P. H. Krammer, P. R. Galle, and W. Stremmel. 1998. Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. J Clin Invest 102:1506–1514.

    Article  CAS  PubMed  Google Scholar 

  • Ryter, S. W., H. P. Kim, A. Hoetzel, J. W. Park, K. Nakahira, X. Wang, and A. M. Choi. 2007. Mechanisms of cell death in oxidative stress. Antioxid Redox Signal 9(1):49–89.

    Article  CAS  PubMed  Google Scholar 

  • Sakai, K., M. Takiguchi, S. Mori, O. Kobori, Y. Morioka, H. Inoko, M. Sekiguchi, and K. Kano. 1987. Expression and function of class II antigens on gastric carcinoma cells and gastric epi-thelia: differential expression of DR, DQ, and DP antigens. J Natl Cancer Inst 79:923–932.

    CAS  PubMed  Google Scholar 

  • Sarsfield, P., D. B. Jones, A. C. Wotherspoon, T. Harvard, and D. H. Wright. 1996. A study of accessory cells in the acquired lymphoid tissue of Helicobacter gastritis. J Pathol 180(1):18–25.

    Article  CAS  PubMed  Google Scholar 

  • Sebkova, L., A. Pellicano, G. Monteleone, B. Grazioli, G. Guarnieri, M. Imeneo, F. Pallone, and F. Luzza. 2004. Extracellular signal-regulated protein kinase mediates interleukin 17 (IL-17)-induced IL-8 secretion in Helicobacter pylori-infected human gastric epithelial cells. Infect Immun 72(9):5019–5026.

    Article  CAS  PubMed  Google Scholar 

  • Sharma, S. A., M. K. Tummuru, M. J. Blaser, and L. D. Kerr. 1998. Activation of IL-8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappa B in gastric epithelial cells. J Immunol 160:2401–2407.

    CAS  PubMed  Google Scholar 

  • Sher, A., D. Fiorentino, P. Caspar, E. Pearce, and T. R. Mosmann. 1991. Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection. J Immunol 147:2713–2716.

    CAS  PubMed  Google Scholar 

  • Shibolet, O. and D. K. Podolsky. 2007. TLRs in the Gut. IV. Negative regulation of Toll-like receptors and intestinal homeostasis: addition by subtraction. Am J Physiol Gastrointest Liver Physiol 292(6):G1469–G1473.

    Article  CAS  PubMed  Google Scholar 

  • Singh, N., Y. Sun, K. Nakamura, M. R. Smith, and N. H. Colburn. 1995. C-JUN/AP-1 as possible mediators of tumor necrosis factor-a-induced apoptotic response in mouse JB6 tumor cells. Oncol Res 7:353–362.

    CAS  PubMed  Google Scholar 

  • Sitkovsky, M. V., D. Lukashev, S. Apasov, H. Kojima, M. Koshiba, C. Caldwell, A. Ohta, and M. Thiel. 2004. Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors. Annu Rev Immunol 22:657–682.

    Article  CAS  PubMed  Google Scholar 

  • Smith, M. F., Jr., A. Mitchell, G. Li, S. Ding, A. M. Fitzmaurice, K. Ryan, S. E. Crowe, and J. B. Goldberg. 2003. TLR2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells. J Biol Chem 278(35):32552–32560.

    Article  CAS  PubMed  Google Scholar 

  • Smith, P. D., C. Ochsenbauer-Jambor, and L. E. Smythies. 2005. Intestinal macrophages: unique effector cells of the innate immune system. Immunol Rev 206:149–159.

    Article  CAS  PubMed  Google Scholar 

  • Su, B., P. J. Ceponis, S. Lebel, H. Huynh, and P. M. Sherman. 2003. Helicobacter pylori activates Toll-like receptor 4 expression in gastrointestinal epithelial cells. Infect Immun 71:3496–3502.

    Article  CAS  PubMed  Google Scholar 

  • Tebbutt, N. C., A. S. Giraud, M. Inglese, B. Jenkins, P. Waring, F. J. Clay, S. Malki, et al. 2002. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med 8(10):1089–1097.

    Article  CAS  PubMed  Google Scholar 

  • Tell, G., A. Zecca, L. Pellizzari, P. Spessotto, A. Colombatti, M. R. Kelley, G. Damante, and C. Pucillo. 2000. An “environment to nucleus” signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation. Nucleic Acids Res 28:1099–1105.

    Article  CAS  PubMed  Google Scholar 

  • Thomas, P. G., M. R. Carter, A. A. Da'dara, T. M. DeSimone, and D. A. Harn. 2005. A helminth glycan induces APC maturation via alternative NF-kappa B activation independent of I kappa B alpha degradation. J Immunol 175(4):2082–2090.

    CAS  PubMed  Google Scholar 

  • Viala, J., C. Chaput, I. G. Boneca, A. Cardona, S. E. Girardin, A. P. Moran, R. Athman, et al. 2004. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol 5(11):1166–1174.

    Article  CAS  PubMed  Google Scholar 

  • Wagner, S., W. Beil, J. Westermann, R. P. Logan, C. T. Bock, C. Trautwein, J. S. Bleck, and M. P. Manns. 1997. Regulation of gastric epithelial cell growth by Helicobacter pylori: evidence for a major role of apoptosis. Gastroenterology 113(6):1836–1847.

    Article  CAS  PubMed  Google Scholar 

  • Wakkach, A., N. Fournier, V. Brun, J. P. Breittmayer, F. Cottrez, and H. Groux. 2003. Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 18(5):605–617.

    Article  CAS  PubMed  Google Scholar 

  • Walker, L. J., R. B. Craig, A. L. Harris, and I. D. Hickson. 1994. A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress. Nucleic Acids Res 22:4884–4889.

    Article  CAS  PubMed  Google Scholar 

  • Wang, J., X. J. Fan, C. Lindholm, M. Bennet, J. O'Connell, F. Shanahan, E. G. Brooks, V. E. Reyes, and P. B. Ernst. 2000. Helicobacter pylori modulates lymphoepithelial cell interactions leading to epithelial cell damage through Fas/Fas Ligand interactions. Infect Immun 68:4303–4311.

    Article  CAS  PubMed  Google Scholar 

  • Weiner, H. L. 2001. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol Rev 182:207–214.

    Article  CAS  PubMed  Google Scholar 

  • Wilson, K. T. and J. E. Crabtree. 2007. Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies. Gastroenterology 133(1):288–308.

    Article  CAS  PubMed  Google Scholar 

  • Wiseman, H. and B. Halliwell. 1996. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J 313:17–29.

    CAS  PubMed  Google Scholar 

  • Wu, M. S., S. P. Huang, Y. T. Chang, C. T. Shun, M. C. Chang, M. T. Lin, H. P. Wang, and J. T. Lin. 2002. Tumor necrosis factor-alpha and interleukin-10 promoter polymorphisms in Epstein-Barr virus-associated gastric carcinoma. J Infect Dis 185(1):106–109.

    Article  CAS  PubMed  Google Scholar 

  • Wu, M.-S., C.-T. Shun, H.-P. Wang, J.-C. Sheu, W.-J. Lee, T.-H. Wang, and J.-T. Lin. 1997. Genetic alterations in gastric cancer: Relation to histological subtypes, tumor stage, and Helicobacter pylori infection. Gastroenterology 112:1457–1465.

    Article  CAS  PubMed  Google Scholar 

  • Wyllie, A. H. 1997. Apoptosis and carcinogenesis. Eur J Cell Biol 73:189–197.

    CAS  PubMed  Google Scholar 

  • Xanthoudakis, S., G. G. Miao, and T. Curran. 1994. The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains. Proc Natl Acad Sci USA 91(1):23–27.

    Article  CAS  PubMed  Google Scholar 

  • Xanthoudakis, S., G. Miao, F. Wang, Y.-C. E. Pan, and T. Curran. 1992. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J 11:3323–3335.

    CAS  PubMed  Google Scholar 

  • Xanthoudakis, S., R. J. Smeyne, J. D. Wallace, and T. Curran. 1996. The redox DNA repair pro tein, Ref-1, is essential for early embryonic development in mice. Proc Natl Acad Sci 93:8919–8923.

    Article  CAS  PubMed  Google Scholar 

  • Yahiro, K., A. Wada, M. Nakayama, T. Kimura, K. Ogushi, T. Niidome, H. Aoyagi, et al. 2003. Protein-tyrosine phosphatase alpha, RPTP alpha, is a Helicobacter pylori VacA receptor. J Biol Chem 278(21):19183–19189.

    Article  CAS  PubMed  Google Scholar 

  • Yamasaki, E., A. Wada, A. Kumatori, I. Nakagawa, J. Funao, M. Nakayama, J. Hisatsune, et al. 2006. Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation. J Biol Chem 281(16):11250–11259.

    Article  CAS  PubMed  Google Scholar 

  • Ye, G., C. Barrera, X. J. Fan, W. K. Gourley, S. E. Crowe, P. B. Ernst, and V. E. Reyes. 1997. Expression of B7-1 and B7-2 costimulatory molecules by human gastric epithelial cells. Potential role in CD4+ T cell activation during Helicobacter pylori infection. J Clin Invest 99:1628–1636.

    Article  CAS  PubMed  Google Scholar 

  • Yokota, K., K. Kobayashi, Y. Kawahara, S. Hayashi, Y. Hirai, M. Mizuno, H. Okada, et al. 1999. Gastric ulcers in SCID mice induced by Helicobacter pylori infection after transplanting lymphocytes from patients with gastric lymphoma. Gastroenterology 117:893–899.

    Article  CAS  PubMed  Google Scholar 

  • Yoshimura, S., J. Bondeson, B. M. Foxwell, F. M. Brennan, and M. Feldmann. 2001. Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines. Int Immunol 13(5):675–683.

    Article  CAS  PubMed  Google Scholar 

  • Zhou, P., R. Borojevic, C. Streutker, D. Snider, H. Liang, and K. Croitoru. 2004. Expression of dual TCR on DO11.10 T cells allows for ovalbumin-induced oral tolerance to prevent T cell-mediated colitis directed against unrelated enteric bacterial antigens. J Immunol 172(3):1515–1523.

    CAS  PubMed  Google Scholar 

  • Zhou, L., I. I. Ivanov, R. Spolski, R. Min, K. Shenderov, T. Egawa, D. E. Levy, W. J. Leonard, and D. R. Littman. 2007. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 8(9):967–974.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Department of Medicine, University of Virginia, Charlottesville, VA, USA

    Peter B. Ernst, Mohammad S. Alam, Asima Bhattacharyya & Sheila E. Crowe

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  1. Peter B. Ernst
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  2. Mohammad S. Alam
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  3. Asima Bhattacharyya
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  1. Division of Digestive and Liver Diseases, Columbia University, New York, NY, USA

    Timothy C. Wang (Silberberg Professor of Medicine Chair) (Silberberg Professor of Medicine Chair)

  2. Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

    James G. Fox (Director, Professor) (Director, Professor)

  3. Immunity and Environment Murdoch Childrens Research Institute, Royal Melbourne Hospital Footscray, Melbourne, Australia

    Andrew S. Giraud (Professor and Research Theme Director Infection) (Professor and Research Theme Director Infection)

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Ernst, P.B., Alam, M.S., Bhattacharyya, A., Crowe, S.E. (2009). Host Immunity in the Development of Gastric Preneoplasia. In: Wang, T.C., Fox, J.G., Giraud, A.S. (eds) The Biology of Gastric Cancers. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69182-4_17

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