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The Role of Helicobacter pylori Virulence Factors in Rodent and Primate Models of Disease

  • Dawn A. Israel
  • Richard M. PeekJr.

Introduction

Helicobacter pylori colonizes the stomach of at least half of the world's population, and this process usually persists for the lifetime of the host. Virtually all persons infected with H. pylori develop gastric inflammation, which confers an increased risk for developing gastric cancer. However, only a fraction of infected persons ever develop these clinical sequelae. Identification of bacterial biomarkers associated with increased disease risk has profound ramifications because such findings will not only provide mechanistic insights into inflammatory carcinogenesis, but may also identify a subpopula-tion of H. pylori—infected individuals who can then be targeted for intervention.

Animal models provide a unique opportunity to study mechanisms by which H. pylori colonizes its host and to identify bacterial factors related to virulence and the development of disease (Ferraro and Fox 2001; O'Rourke and Lee 2003). Rodents, including mice and gerbils, as well as monkeys...

Keywords

Urease Activity Gastric Epithelial Cell Pylorus Strain Mongolian Gerbil Methionine Sulfoxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Dawn A. Israel
    • 1
  • Richard M. PeekJr.
    • 2
  1. 1.Division of Gastroenterology, Department of MedicineVanderbilt University Medical CenterNashvilleUSA
  2. 2.Division of Gastroenterology, Departments of Medicine and Cancer BiologyVanderbilt University Medical Center, and Department of Veterans Affairs Medical CenterNashvilleUSA

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