Deregulation of E-Cadherin in Precancerous Lesions and Gastric Cancer

  • Annie On On Chan
  • Benjamin Chun-Yu Wong


Gastric cancer remains the second major cause of cancer-related deaths in the world. China and Hong Kong are among the high incidence areas in the world, showing no trend of reduction in gastric cancer incidence over the past 10 years and no improvement in the survival rate. Helicobacter pylori infection is an important etiologic risk factor in gastric cancer, and has been classified as a class I carcinogen by the World Health Organization. However, only a minority of the infected population eventually develop gastric cancer. Molecular studies of the host may give definite proof of the etiologic role of H. pylori in inducing gastric carcinoma.

E-cadherin is a transmembrane glycoprotein expressed on epithelial cells, and is responsible for homotypic cell adhesion. Defective cell adhesion may contribute to loss of contact inhibition of growth, which is an early step in carcinogenesis. The critical role of E-cadherin is underlined by the observation that familial gastric...


Gastric Cancer Adenomatous Polyposis Coli Intestinal Metaplasia Bullous Pemphigoid Diffuse Gastric Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Annie On On Chan
    • 1
  • Benjamin Chun-Yu Wong
    • 1
  1. 1.Department of MedicineUnviersity of Hong KongHong Kong

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