Skip to main content

Insights into the Development of Preneoplastic Metaplasia: Spasmolytic Polypeptide-Expressing Metaplasia and Oxyntic Atrophy

  • Chapter
The Biology of Gastric Cancers

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Biankin, A.V., J.G. Kench, F.P. Dijkman, S.A. Biankin, and S.M. Henshall. 2003. Molecular pathogenesis of precursor lesions of pancreatic ductal adenocarcinoma. Pathology. 35:14–24.

    Article  CAS  PubMed  Google Scholar 

  • Blaser, M. 1992. Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation. Gastroenterology. 102:720–727.

    CAS  PubMed  Google Scholar 

  • Blaser, M., and J. Parsonnet. 1994. Parasitism by the ‘slow’ bacterium Helicobacter pylori leads to altered gastric homeostasis and neoplasia. J Clin Invest. 94:4–8.

    Article  CAS  PubMed  Google Scholar 

  • Borch, K., H. Renvall, and G. Liedberg. 1985. Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemia. Gastroenterology. 88:638–648.

    CAS  PubMed  Google Scholar 

  • Brito, M.J., M.I. Filipe, J. Linehan, and J. Jankowski. 1995. Association of transforming growth factor alpha (TGFA) and its precursors with malignant change in Barrett's epithelium: biological and clinical variables. Int J Cancer. 60:27–32.

    Article  CAS  PubMed  Google Scholar 

  • Burdick, J.S., E. Chung, G. Tanner, M. Sun, J.E. Paciga, J.Q. Cheng, K. Washington, J.R. Goldenring, and R.J. Coffey. 2000. Treatment of Menetrier's disease with a monoclonal antibody against the epidermal growth factor receptor. N Engl J Med. 343:1697–1701.

    Article  CAS  PubMed  Google Scholar 

  • Cameron, A.J., C.T. Lomboy, M. Pera, and H.A. Carpenter. 1995. Adenocarcinoma of the esoph-agogastric junction and Barrett's esophagus. Gastroenterology. 109:1541–1546.

    Article  CAS  PubMed  Google Scholar 

  • Cameron, A.J., B.J. Ott, and W.S. Payne. 1985. The incidence of adenocarcinoma in columnar-lined (Barrett's) esophagus. New Engl J Med. 313:857–859.

    Article  CAS  PubMed  Google Scholar 

  • Canfield, V.A., A.B. West, J.R. Goldenring, and R. Levenson. 1996. Targeted ablation of parietal cells in transgenic mice. Proc Natl Acad Sci USA. 93(6):2431–2435.

    Article  CAS  PubMed  Google Scholar 

  • Coffey, R.J., R. Derynck, J.N. Wilcox, T.S. Bringman, A.S. Goustin, H.L. Moses, and M.R. Pittelkow. 1987. Production and auto-induction of TGF alpha in human keratinocytes. Nature. 328:817–820.

    Article  CAS  PubMed  Google Scholar 

  • Correa, P. 1988. A human model of gastric carcinogenesis. Cancer Res. 48:3554–3560.

    CAS  PubMed  Google Scholar 

  • Courtois-Coutry, N., D. Rousch, V. Rajendran, J.B. McCarthy, J. Geibel, M. Kashgarian, and M.J. Caplan. 1997. A tyrosine-based signal targets H/K-ATPase to a regulated compartment and is required for the cessation of gastric acid secretion. Cell. 90:501–510.

    Article  CAS  PubMed  Google Scholar 

  • Dempsey, P.J., J.R. Goldenring, C.J. Soroka, I.M. Modlin, R.W. McClure, C.D. Lind, D.A. Ahlquist, M.R. Pittlekow, D.C. Lee, E.P. Sandgren, D.L. Page, and R.J. Coffey. 1992. Possible role of TGFa in the pathogenesis of Menetrier's disease: supportive evidence from humans and transgenic mice. Gastroenterology. 103:1950–1963.

    CAS  PubMed  Google Scholar 

  • Dhar, D.K., T.C. Wang, R. Maruyama, J. Udagawa, H. Kubota, T. Fuji, M. Tachibana, T. Ono, H. Otani, and N. Nagasue. 2003. Expression of cytoplasmic TFF2 is a marker of tumor metastasis and negative prognostic factor in gastric cancer. Lab Invest. 83:1343–1352.

    Article  CAS  PubMed  Google Scholar 

  • El-Zimaity, H.M.T., H. Ota, D.Y. Graham, T. Akamatsu, and T. Katsuyama. 2002. Patterns of gastric atrophy in intestinal type gastric carcinoma. Cancer. 94:1428–1436.

    Article  PubMed  Google Scholar 

  • Filipe, M.I., N. Munoz, I. Matko, I. Kato, V. Pompe-Kirn, A. Juersek, S. Teuchmann, M. Benz, and T. Prijon. 1994. Intestinal metaplasia types and the risk of gastric cancer: a cohort study in Slovenia. Int J Cancer. 57:324–329.

    Article  CAS  PubMed  Google Scholar 

  • Fox, J.G., M. Blanco, J.C. Murphy, N.S. Taylor, A. Lee, Z. Kabok, and J. Pappo. 1993. Local and systemic immune responses in murine Helicobacter felis active chronic gastritis. Infect Immun. 61:2309–2315.

    CAS  PubMed  Google Scholar 

  • Fox, J.G., X. Li, R.J. Cahill, K. Andrutis, A.K. Rustgi, R. Odze, and T.C. Wang. 1996. Hypertrophic gastropathy in Helicobacter felis-infected wild type C57BL/6 mice and p53 hemizygous transgenic mice. Gastroenterology. 110:155–166.

    Article  CAS  PubMed  Google Scholar 

  • Fox, J.G., T.C. Wang, A.B. Rogers, T. Poutahidis, Z. Ge, N. Taylor, C.A. Dangler, D.A. Israel, U. Krishna, K. Gaus, and R.M. Peek, Jr. 2003. Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology. 124:1879–1890.

    Article  PubMed  Google Scholar 

  • Goldenring, J.R., and S. Nomura. 2006. Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia. Am J Physiol Gastrointest Liver Physiol. 291:G999–1004.

    Article  CAS  PubMed  Google Scholar 

  • Goldenring, J.R., G.S. Ray, R.J. Coffey, P.C. Meunier, P.J. Haley, T.B. Barnes, and B.D. Car. 2000. Reversible drug-induced oxyntic atrophy in rats. Gastroenterology. 118:1080–1093.

    Article  CAS  PubMed  Google Scholar 

  • Halldorsdottir, A.M., M. Sigurdardottir, J.G. Jonasson, M. Oddsdottir, J. Magnusson, J.R. Lee, and J.R. Goldenring. 2003. Spasmolytic polypeptide expressing metaplasia (SPEM) associated with gastric cancer in Iceland. Dig Dis Sci. 48:431–441.

    Article  CAS  PubMed  Google Scholar 

  • Hattori, T. 1986. Development of adenocarcinomas in the stomach. Cancer. 57:1528–1534.

    Article  CAS  PubMed  Google Scholar 

  • Hattori, T., and S. Fujita. 1979. Tritiated thymidine autoradiographic study on histogenesis and spreading of intestinal metaplasia in human stomach. Pathol Res Pract. 164:224–237.

    CAS  PubMed  Google Scholar 

  • Hattori, T., B. Helpap, and P. Gedigk. 1982. The morphology and cell kinetics of pseudopyloric glands. Virchows Arch B Cell Pathol Incl Mol Pathol. 39:31–40.

    Article  CAS  PubMed  Google Scholar 

  • Houghton, J., C. Stoicov, S. Nomura, J. Carlson, H. Li, A.B. Rogers, J.G. Fox, J.R. Goldenring, and T.C. Wang. 2004. Gastric cancer originating from bone marrow derived cells. Science. 306:1568–1571.

    Article  CAS  PubMed  Google Scholar 

  • Katz, J.P., N. Perreault, B.G. Goldstein, L. Actman, S.R. McNally, D.G. Silberg, E.E. Furth, and K.H. Kaestner. 2005. Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. Gastroenterology. 128:935–945.

    Article  CAS  PubMed  Google Scholar 

  • Kirchner, T., S. Muller, T. Hattori, K. Mukaisyo, T. Papadopoulos, T. Brabletz, and A. Jung. 2001. Metaplasia, intraepithelial neoplasia and early cancer of the stomach are related to dedifferentiated epithelial cells defined by cytokeratin-7 expression in gastritis. Virchows Arch. 439:512–522.

    Article  CAS  PubMed  Google Scholar 

  • Konda, Y., H. Kamimura, H. Yokota, N. Hayashi, K. Sugano, and T. Takeuchi. 1999. Gastrin stimulates the growth of gastric pit with less-differentiated features. Am J Physiol. 277: G773–784.

    CAS  PubMed  Google Scholar 

  • Leys, C.M., S. Nomura, E. Rudzinski, M. Kaminishi, E. Montgomery, M.K. Washington, and J.R. Goldenring. 2006. Expression of Pdx-1 in human gastric metaplasia and gastric adenocar-cinoma. Hum Pathol. 37:1162–1168.

    Article  CAS  PubMed  Google Scholar 

  • Li, Q., S.M. Karam, and J.I. Gordon. 1996. Diphtheria toxin-mediated ablation of parietal cells in the stomach of transgenic mice. J Biol Chem. 271:3671–3676.

    Article  CAS  PubMed  Google Scholar 

  • Lopez-Diaz, L., K.L. Hinkle, R.N. Jain, Y. Zavros, C.S. Brunkan, T. Keeley, K.A. Eaton, J.L. Merchant, C.S. Chew, and L.C. Samuelson. 2006. Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice. Am J Physiol Gastrointest Liver Physiol. 290: G970–979.

    Article  CAS  PubMed  Google Scholar 

  • Marshall, A.C., F. Alderuccio, K. Murphy, and B.H. Toh. 2005. Mechanisms of gastric mucosal cell loss in autoimmune gastritis. Int Rev Immunol. 24:123–134.

    Article  CAS  PubMed  Google Scholar 

  • Means, A.L., I.M. Meszoely, K. Suzuki, Y. Miyamoto, A.K. Rustgi, R.J. Coffey, Jr., C.V. Wright, D.A. Stoffers, and S.D. Leach. 2005. Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development.132:3767–3776.

    Article  CAS  PubMed  Google Scholar 

  • Mutoh, H., Y. Hakamata, K. Sato, A. Eda, I. Yanaka, S. Honda, H. Osawa, Y. Kaneko, and K. Sugano. 2002. Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice. Biochem Biophys Res Commun. 294:470–479.

    Article  CAS  PubMed  Google Scholar 

  • Nam, K.T., A. Varro, R.J. Coffey, and J.R. Goldenring. 2007. Potentiation of oxyntic atrophy-induced gastric metaplasia in amphiregulin-deficient mice. Gastroenterology. 132:1804–1819.

    Article  CAS  PubMed  Google Scholar 

  • Nomura, S., S.H. Settle, C. Leys, A.L. Means, R.M. Peek, Jr., S.D. Leach, C.V.E. Wright, R.J. Coffey, and J.R. Goldenring. 2005. Evidence for repatterning of the gastric fundic epithelium associated with Menetrier's disease and TGFa overexpression. Gastroenterology. 128:1292–1305.

    Article  CAS  PubMed  Google Scholar 

  • Nomura, S., H. Yamaguchi, T.C. Wang, J.R. Lee, and J.R. Goldenring. 2004. Alterations in gastric mucosal lineages induced by acute oxyntic atrophy in wild type and gastrin deficient mice. Am J Physiol. 288:G362–G375.

    Google Scholar 

  • Nozaki, K., M. Ogawa, J.A. Williams, B.J. LaFleur, V. Ng, R.I. Drapkin, J.C. Mills, S.F. Konieczny, S. Nomura, and J.R. Goldenring. 2008. A molecular signature of gastric metaplasia arising in response to acute parietal cell loss. Gastroenterology. 134(2):511–522.

    Article  CAS  PubMed  Google Scholar 

  • Ogawa, T., K. Maeda, S. Tonai, T. Kobayashi, T. Watanabe, and S. Okabe. 2003. Utilization of knockout mice to examine the potential role of gastric histamine H2-receptors in Menetrier's disease. J Pharmacol Sci. 91:61–70.

    Article  CAS  PubMed  Google Scholar 

  • Ogawa, M., S. Nomura, B.D. Car, and J.R. Goldenring. 2006a. Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777. Dig Dis Sci. 51:431–439.

    Article  CAS  Google Scholar 

  • Ogawa, M., S. Nomura, A. Varro, T.C. Wang, and J.R. Goldenring. 2006b. Altered metaplastic response of waved-2 EGF receptor mutant mice to acute oxyntic atrophy. Am J Physiol Gastrointest Liver Physiol. 290:G793–804.

    Article  CAS  Google Scholar 

  • Ormand, J.E., N.J. Talley, R.G. Shorter, C.R. Conley, H.A. Carpenter, A. Fich, W.R. Wilson, and S.F. Phillips. 1991. Prevalence of Helicobacter pylori in specific forms of gastritis: further evidence supporting a pathogenic role for H. pylori in chronic nonspecific gastritis. Dig Dis Sci. 36:142–145.

    Article  CAS  PubMed  Google Scholar 

  • Oshima, M., H. Oshima, A. Matsunaga, and M.M. Taketo. 2005. Hyperplastic gastric tumors with spasmolytic polypeptide-expressing metaplasia caused by tumor necrosis factor-alpha-dependent inflammation in cyclooxygenase-2/microsomal prostaglandin E synthase-1 trans-genic mice. Cancer Res. 65:9147–9151.

    Article  CAS  PubMed  Google Scholar 

  • Parsonnet, J., G.D. Friedman, D.P. Vandersteen, Y. Chang, J.H. Vogelman, N. Orentreich, and R.K. Sibley. 1991. Helicobacter pylori infection and the risk of gastric cancer. New Engl J Med. 325:1127–1131.

    Article  CAS  PubMed  Google Scholar 

  • Peura, D.A. 1997. The report of the Digestive Health Initiative international update conference on Helicobacter pylori. Gastroenterology. 113:S4–S8.

    Google Scholar 

  • Pisani, P., D.M. Parkin, F. Bray, and J. Ferlay. 1999. Estimates of the worldwide mortality from 25 cancers in 1990. Int J Cancer. 83:18–29.

    Article  CAS  PubMed  Google Scholar 

  • Rembacken, B., T. Fujii, and H. Kondo. 2001. The recognition and endoscopic treatment of early gastric and colonic cancer. Best Pract Res Clin Gastroenterol. 15:317–336.

    Article  CAS  PubMed  Google Scholar 

  • Schmidt, P.H., J.R. Lee, V. Joshi, R.J. Playford, R. Poulsom, N.A. Wright, and J.R. Goldenring. 1999. Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Lab Invest. 79:639–646.

    CAS  PubMed  Google Scholar 

  • Sharp, R., M.W. Babyatsky, H. Takagi, S. Tagerud, T.C. Wang, D.E. Bockman, S.E. Brand, and G. Merlino. 1995. Transforming growth factor alpha disrupts the normal program of cellular differentiation in the gastric mucosa of transgenic mice. Development. 121:149–161.

    CAS  PubMed  Google Scholar 

  • Silberg, D.G., J. Sullivan, E. Kang, G.P. Swain, J. Moffett, N.J. Sund, S.D. Sackett, and K.H. Kaestner. 2002. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology. 122:689–696.

    Article  CAS  PubMed  Google Scholar 

  • Takizawa, T., and M. Koike. 1998. Minute gastri carcinoma from pathomorphological aspect— reconsideration concerning histogenesis of gastric carcinomas. Stomach Intestine. 23:791–800.

    Google Scholar 

  • Wainess, R.M., J.B. Dimick, G.R. Upchurch, Jr., J.A. Cowan, and M.W. Mulholland. 2003. Epidemiology of surgically treated gastric cancer in the United States, 1988–2000. J Gastrointest Surg. 7:879–883.

    PubMed  Google Scholar 

  • Wang, T.C., C.A. Dangler, D. Chen, J.R. Goldenring, T. Koh, R. Raychowdhury, R.J. Coffey, S. Ito, A. Varro, G.J. Dockray, and J.G. Fox. 2000. Synergistic interaction between hypergas-trinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology. 118:36–47.

    Article  CAS  PubMed  Google Scholar 

  • Wang, T.C., J.R. Goldenring, C. Dangler, S. Ito, A. Mueller, W.K. Jeon, T.J. Koh, and J.G. Fox. 1998. Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection. Gastroenterology. 114:675–689.

    Article  CAS  PubMed  Google Scholar 

  • Wolfsen, H.C., H.A. Carpenter, and N.J. Talley. 1993. Menetrier's disease: a form of hypertrophic gastropathy or gastritis? Gastroenterology. 104:1310–1319.

    CAS  PubMed  Google Scholar 

  • Wright, N.A., C. Pike, and G. Elia. 1990. Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells. Nature. 343:82–85.

    Article  CAS  PubMed  Google Scholar 

  • Xia, H.H., J.S. Kalantar, N.J. Talley, J.M. Wyatt, S. Adams, K. Cheung, and H.M. Mitchell. 2000.Antral-type mucosa in the gastric incisura, body and fundus (antralization): a link between Helicobacter pylori infection and intestinal metaplasia. Am J Gastroenterol. 95:114–121.

    Article  CAS  PubMed  Google Scholar 

  • Yamaguchi, H., J.R. Goldenring, M. Kaminishi, and J.R. Lee. 2001. Identification of spasmolytic polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance post-gastrectomy biopsies. Dig Dis Sci. 47:573–578.

    Article  Google Scholar 

  • Yamaguchi, H., J.R. Goldenring, M. Kaminishi, and J.R. Lee. 2002. Association of spasmolytic polypeptide expressing metaplasia (SPEM) with carcinogen administration and oxyntic atrophy in rats. Lab Invest. 82:1045–1052.

    CAS  PubMed  Google Scholar 

  • Yoshizawa, N., Y. Takenaka, H. Yamaguchi, T. Tetsuya, H. Tanaka, M. Tatematsu, S. Nomura, J.R. Goldenring, and M. Kaminishi. 2007. Emergence of spasmolytic polypeptide-expressing metaplasia in Mongolian gerbils infected with Helicobacter pylori. Lab Invest. 87:1265–1276.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer Science + Business Media, LLC

About this chapter

Cite this chapter

Goldenring, J.R., Nomura, S. (2009). Insights into the Development of Preneoplastic Metaplasia: Spasmolytic Polypeptide-Expressing Metaplasia and Oxyntic Atrophy. In: Wang, T.C., Fox, J.G., Giraud, A.S. (eds) The Biology of Gastric Cancers. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69182-4_13

Download citation

Publish with us

Policies and ethics