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Animal Models of Gastric Carcinoma

  • Arlin B. Rogers
  • James G. Fox

Introduction

Animal models are an indispensable resource for investigating the causes of gastric cancer, and for identifying new preventative and therapeutic measures. In the late 1980s, experimental Helicobacter mustelae infection of domestic ferrets provided the first proof-of-principle that Helicobacter colonization was sufficient to incite chronic gastritis, helping to dispel skepticism over the pathogenic role of H. pylori in human gastrointestinal disease (Fox et al. 1990). Today, there is a choice of well-characterized and emerging animal models of gastric Helicobacterinfection. In addition to infectious agents, animal models serve as sentinels for chemical and environmental gastric carcinogens, and are used to identify toxic principles within complex chemical compounds. Increasingly, animal models are being used to investigate tumorigenic synergism between multiple risk factors, both environmental and infectious. Rodent models in general, and mice in particular, have emerged...

Keywords

Gastric Cancer Gastric Carcinoma Pylorus Infection Mongolian Gerbil Gastric Carcinogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Arlin B. Rogers
    • 1
  • James G. Fox
    • 1
  1. 1.Division of Comparative Medicine, Department of Biological EngineeringMassachusetts Institute of TechnologyCambridgeUSA

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