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Animal Models of Gastric Carcinoma

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The Biology of Gastric Cancers

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References

  • Acheson, D. W., and Luccioli, S. 2004. Microbial-gut interactions in health and disease. Mucosal immune responses. Best Pract Res Clin Gastroenterol 18:387–404.

    CAS  PubMed  Google Scholar 

  • Babinet, C., Morello, D., and Renard, J. P. 1989. Transgenic mice. Genome 31:938–949.

    CAS  PubMed  Google Scholar 

  • Barker, I., and Dreumel, A. 1985. The alimentary system. In: Jubb, K., Kennedy, P., and Palmer, N., editors. Pathology of domestic animals. New York: Academic Press; pp. 1–237.

    Google Scholar 

  • Bergin, I. L., Sheppard, B. J., and Fox, J. G. 2003. Helicobacter pylori infection and high dietary salt independently induce atrophic gastritis and intestinal metaplasia in commercially available outbred Mongolian gerbils. Dig Dis Sci 48:475–485.

    CAS  PubMed  Google Scholar 

  • Blanchard, T., Nedrud, J., and Czinn, S. 1996. Development of a rat model of H. pylori infection and disease to study the role of H. pylori in gastric cancer incidence. Gut 39:A76.

    Google Scholar 

  • Bolon, B. 2004. Genetically engineered animals in drug discovery and development: a maturing resource for toxicologic research. Basic Clin Pharmacol Toxicol 95:154–161.

    CAS  PubMed  Google Scholar 

  • Bolon, B. 2006. Internet resources for phenotyping engineered rodents. Ilar J 47:163–171.

    CAS  PubMed  Google Scholar 

  • Bonne, C., and Sandground, J. 1939. On the production of gastric tumors, bordering on malignancy in Javenese monkeys through the agency of Nochtia nochti, a parasitic nematoda. Am J Cancer 37:173–185.

    Google Scholar 

  • Boonjakuakul, J. K., Canfield, D. R., and Solnick, J. V. 2005. Comparison of Helicobacter pylori virulence gene expression in vitro and in the Rhesus macaque. Infect Immun 73:4895–4904.

    CAS  PubMed  Google Scholar 

  • Brack, M. 1998. Gastrointestinal tumors observed in nonhuman primates at the German primate center. J Med Primatol 27:319–324.

    CAS  PubMed  Google Scholar 

  • Bralow, S. P. 1972. Experimental gastric carcinogenesis. Digestion 5:290–310.

    CAS  PubMed  Google Scholar 

  • Brayton, C., Justice, M., and Montgomery, C. A. 2001. Evaluating mutant mice: anatomic pathology. Vet Pathol 38:1–19.

    CAS  PubMed  Google Scholar 

  • Buiatti, E., Palli, D., Decarli, A., Amadori, D., Avellini, C., Bianchi, S., Biserni, R., Cipriani, F., Cocco, P., Giacosa, A., et al. 1989. A case-control study of gastric cancer and diet in Italy. Int J Cancer 44:611–616.

    CAS  PubMed  Google Scholar 

  • Cai, X., Carlson, J., Stoicov, C., Li, H., Wang, T. C., and Houghton, J. 2005. Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice. Gastroenterology 128:1937–1952.

    CAS  PubMed  Google Scholar 

  • Campbell, R. S., and Lauder, I. M. 1952. Gastric carcinoma in the dog. J Comp Pathol 62:275–278.

    CAS  PubMed  Google Scholar 

  • Charnley, G., and Tannenbaum, S. R. 1985. Flow cytometric analysis of the effect of sodium chloride on gastric cancer risk in the rat. Cancer Res 45:5608–5616.

    CAS  PubMed  Google Scholar 

  • Chen, D., Stenstrom, B., Zhao, C. M., and Wadstrom, T. 2007. Does Helicobacter pylori infection per se cause gastric cancer or duodenal ulcer? Inadequate evidence in Mongolian gerbils and inbred mice. FEMS Immunol Med Microbiol 50:184–189.

    CAS  PubMed  Google Scholar 

  • Citino, S. B., and Munson, L. 2005. Efficacy and long-term outcome of gastritis therapy in cheetahs (Acinonyx jubatus). J Zoo Wildl Med 36:401–416.

    PubMed  Google Scholar 

  • Correa, P. 1992. Human gastric carcinogenesis: a multistep and multifactorial process—first American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 52:6735–6740.

    CAS  PubMed  Google Scholar 

  • Correa, P., Fontham, E., Pickle, L. W., Chen, V., Lin, Y. P., and Haenszel, W. 1985. Dietary determinants of gastric cancer in south Louisiana inhabitants. J Natl Cancer Inst 75:645–654.

    CAS  PubMed  Google Scholar 

  • Court, M., Robinson, P. A., Dixon, M. F., Jeremy, A. H., and Crabtree, J. E. 2003. The effect of gender on Helicobacter felis-mediated gastritis, epithelial cell proliferation, and apoptosis in the mouse model. J Pathol 201:303–311.

    CAS  PubMed  Google Scholar 

  • Croinin, T. O., McCormack, A., van Vliet, A. H., Kusters, J. G., and Bourke, B. 2007. Random mutagenesis to identify novel Helicobacter mustelae virulence factors. FEMS Immunol Med Microbiol 50:257–263.

    CAS  PubMed  Google Scholar 

  • De Bock, M., D'Herde, K., Duchateau, L., Hellemans, A., Decostere, A., Haesebrouck, F., and Ducatelle, R. 2006. The effect of Helicobacter felis and Helicobacter bizzozeronii on the gastric mucosa in Mongolian gerbils: a sequential pathological study. J Comp Pathol 135:226–236.

    PubMed  Google Scholar 

  • Dennis, M. M., Bennett, N., and Ehrhart, E. J. 2006. Gastric adenocarcinoma and chronic gastritis in two related Persian cats. Vet Pathol 43:358–362.

    CAS  PubMed  Google Scholar 

  • de Vries, A. C., Haringsma, J., and Kuipers, E. J. 2007. The detection, surveillance and treatment of premalignant gastric lesions related to Helicobacter pylori infection. Helicobacter 12:1–15.

    PubMed  Google Scholar 

  • Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Jr., Butel, J. S., and Bradley, A. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356:215–221.

    CAS  PubMed  Google Scholar 

  • Dontenwill, W., Chevalier, H. J., Harke, H. P., Lafrenz, U., Reckzeh, G., and Schneider, B. 1973. Investigations on the effects of chronic cigarette-smoke inhalation in Syrian golden hamsters. J Natl Cancer Inst 51:1781–1832.

    CAS  PubMed  Google Scholar 

  • Dubois, A., Fiala, N., Heman-Ackah, L. M., Drazek, E. S., Tarnawski, A., Fishbein, W. N., Perez-Perez, G. I., and Blaser, M. J. 1994. Natural gastric infection with Helicobacter pylori in monkeys: a model for spiral bacteria infection in humans. Gastroenterology 106:1405–1417.

    CAS  PubMed  Google Scholar 

  • Esteves, M. I., Schrenzel, M. D., Marini, R. P., Taylor, N. S., Xu, S., Hagen, S., Feng, Y., Shen, Z., and Fox, J. G. 2000. Helicobacter pylori gastritis in cats with long-term natural infection as a model of human disease. Am J Pathol 156:709–721.

    CAS  PubMed  Google Scholar 

  • Forman, D. 1991. Helicobacter pylori infection: a novel risk factor in the etiology of gastric cancer. J Natl Cancer Inst 83:1702–1703.

    CAS  PubMed  Google Scholar 

  • Fostel, J. M., Burgoon, L., Zwickl, C., Lord, P., Corton, J. C., Bushel, P. R., Cunningham, M., Fan, L., Edwards, S. W., Hester, S., Stevens, J., Tong, W., Waters, M., Yang, C., and Tennant, R. 2007. Toward a checklist for exchange and interpretation of data from a toxicology study. Toxicol Sci 99:26–34.

    CAS  PubMed  Google Scholar 

  • Fox, J. G. 1995. Non-human reservoirs of Helicobacter pylori. Aliment Pharmacol Ther 9(Suppl 2): 93–103.

    PubMed  Google Scholar 

  • Fox, J. G. 1998. Biology and diseases of the ferret. Baltimore: Williams and Wilkins.

    Google Scholar 

  • Fox, J. G., Batchelder, M., Marini, R., Yan, L., Handt, L., Li, X., Shames, B., Hayward, A., Campbell, J., and Murphy, J. C. 1995. Helicobacter pylori-induced gastritis in the domestic cat. Infect Immun 63:2674–2681.

    CAS  PubMed  Google Scholar 

  • Fox, J. G., Beck, P., Dangler, C. A., Whary, M. T., Wang, T. C., Shi, H. N., and Nagler-Anderson, C. 2000. Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces Helicobacter-induced gastric atrophy. Nat Med 6:536–542.

    CAS  PubMed  Google Scholar 

  • Fox, J. G., Blanco, M., Murphy, J. C., Taylor, N. S., Lee, A., Kabok, Z., and Pappo, J. 1993. Local and systemic immune responses in murine Helicobacter felis active chronic gastritis. Infect Immun 61:2309–2315.

    CAS  PubMed  Google Scholar 

  • Fox, J. G., Cabot, E. B., Taylor, N. S., and Laraway, R. 1988. Gastric colonization by Campylobacter pylori subsp. mustelae in ferrets. Infect Immun 56:2994–2996.

    CAS  PubMed  Google Scholar 

  • Fox, J. G., Chilvers, T., and Goodwin, C. 1989. Campylobacter mustelae, a new species resulting from the elevation of Campylobacter pylori subsp. mustelae to species status. Int J Sys Bacteriol 39:301–303.

    Google Scholar 

  • Fox, J. G., Correa, P., Taylor, N. S., Lee, A., Otto, G., Murphy, J. C., and Rose, R. 1990. Helicobacter mustelae-associated gastritis in ferrets. An animal model of Helicobacter pylori gastritis in humans. Gastroenterology 99:352–361.

    CAS  PubMed  Google Scholar 

  • Fox, J. G., Dangler, C. A., Sager, W., Borkowski, R., and Gliatto, J. M. 1997. Helicobacter mustelae-associated gastric adenocarcinoma in ferrets (Mustela putorius furo). Vet Pathol 34:225–229.

    CAS  PubMed  Google Scholar 

  • Fox, J. G., Dangler, C. A., Taylor, N. S., King, A., Koh, T. J., and Wang, T. C. 1999. High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL/6 mice. Cancer Res 59:4823–4828.

    CAS  PubMed  Google Scholar 

  • Fox, J. G., Dangler, C. A., Whary, M. T., Edelman, W., Kucherlapati, R., and Wang, T. C. 1997. Mice carrying a truncated Apc gene have diminished gastric epithelial proliferation, gastric inflammation, and humoral immunity in response to Helicobacter felis infection. Cancer Res 57:3972–3978.

    CAS  PubMed  Google Scholar 

  • Fox, J. G., Edrise, B. M., Cabot, E. B., Beaucage, C., Murphy, J. C., and Prostak, K. S. 1986. Campylobacter-like organisms isolated from gastric mucosa of ferrets. Am J Vet Res 47:236–239.

    CAS  PubMed  Google Scholar 

  • Fox, J. G., and Lee, A. 1993. Gastric Helicobacter infection in animals: natural and experimental infections. In: Goodwin, C., and Worsley, B., editors. Biology and clinical practice. Boca Raton, FL: CRC Press; pp. 407–430.

    Google Scholar 

  • Fox, J. G., Lee, A., Otto, G., Taylor, N. S., and Murphy, J. C. 1991. Helicobacter felis gastritis in gnotobiotic rats: an animal model of Helicobacter pylori gastritis. Infect Immun 59:785–791.

    Google Scholar 

  • Fox, J. G., Li, X., Cahill, R. J., Andrutis, K., Rustgi, A. K., Odze, R., and Wang, T. C. 1996. Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL/6 mice and p53 hemizygous transgenic mice. Gastroenterology 110:155–166.

    CAS  PubMed  Google Scholar 

  • Fox, J. G., Li, X., Yan, L., Cahill, R. J., Hurley, R., Lewis, R., and Murphy, J. C. 1996. Chronic proliferative hepatitis in A/JCr mice associated with persistent Helicobacter hepaticus infection: a model of Helicobacter-induced carcinogenesis. Infect Immun 64:1548–1558.

    CAS  PubMed  Google Scholar 

  • Fox, J. G., Rogers, A. B., Ihrig, M., Taylor, N. S., Whary, M. T., Dockray, G., Varro, A., and Wang, T. C. 2003. Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific. Cancer Res 63:942–950.

    CAS  PubMed  Google Scholar 

  • Fox, J. G., Rogers, A. B., Whary, M. T., Ge, Z., Ohtani, M., Jones, E. K., and Wang, T. C. 2007. Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2/C57BL6 x Sv129 Helicobacter pylori-infected mice. Am J Pathol 171:1520–1528.

    CAS  PubMed  Google Scholar 

  • Fox, J. G., Sheppard, B. J., Dangler, C. A., Whary, M. T., Ihrig, M., and Wang, T. C. 2002. Germ-line p53-targeted disruption inhibits Helicobacter-induced premalignant lesions and invasive gastric carcinoma through down-regulation of Th1 proinflammatory responses. Cancer Res 62:696–702.

    CAS  PubMed  Google Scholar 

  • Fox, J. G., Taylor, N. S., Howe, S., Tidd, M., Xu, S., Paster, B. J., and Dewhirst, F. E. 2006. Helicobacter anseris sp. nov. and Helicobacter brantae sp. nov., isolated from feces of resident Canada geese in the greater Boston area. Appl Environ Microbiol 72:4633–4637.

    CAS  PubMed  Google Scholar 

  • Fox, J. G., and Wang, T. C. 2007. Inflammation, atrophy, and gastric cancer. J Clin Invest 117:60–69.

    CAS  PubMed  Google Scholar 

  • Fox, J. G., Wang, T. C., Rogers, A. B., Poutahidis, T., Ge, Z., Taylor, N., Dangler, C. A., Israel, D. A., Krishna, U., Gaus, K., and Peek, R. M., Jr. 2003. Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology 124:1879–1890.

    PubMed  Google Scholar 

  • Fox, J. G., Wishnok, J. S., Murphy, J. C., Tannenbaum, S. R., and Correa, P. 1993. MNNG-induced gastric carcinoma in ferrets infected with Helicobacter mustelae. Carcinogenesis 14:1957–1961.

    CAS  PubMed  Google Scholar 

  • Franco, A. T., Israel, D. A., Washington, M. K., Krishna, U., Fox, J. G., Rogers, A. B., Neish, A. S., Collier-Hyams, L., Perez-Perez, G. I., Hatakeyama, M., Whitehead, R., Gaus, K., O'Brien, D. P., Romero-Gallo, J., and Peek, R. M., Jr. 2005. Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci USA 102:10646–10651.

    CAS  PubMed  Google Scholar 

  • Freedman, N. D., Abnet, C. C., Leitzmann, M. F., Mouw, T., Subar, A. F., Hollenbeck, A. R., and Schatzkin, A. 2007. A prospective study of tobacco, alcohol, and the risk of esophageal and gastric cancer subtypes. Am J Epidemiol 165:1424–1433.

    PubMed  Google Scholar 

  • Friedman, G. D., and Parsonnet, J. 1992. Salt intake and stomach cancer: some contrary evidence. Cancer Epidemiol Biomarkers Prev 1:607–608.

    CAS  PubMed  Google Scholar 

  • Fujimura, S., Kogure, K., Oboshi, S., and Sugimura, T. 1970. Production of tumors in glandular stomach of hamsters by N-methyl-N′-nitro-N-nitrosoguanidine. Cancer Res 30:1444–1448.

    CAS  PubMed  Google Scholar 

  • Fujioka, T., Murakami, K., Kodama, M., Kagawa, J., Okimoto, T., and Sato, R. 2002. Helicobacter pylori and gastric carcinoma—from the view point of animal model. Keio J Med 51(Suppl 2): 69–73.

    PubMed  Google Scholar 

  • Furihata, C., Sato, Y., Hosaka, M., Matsushima, T., Furukawa, F., and Takahashi, M. 1984. NaCl induced ornithine decarboxylase and DNA synthesis in rat stomach mucosa. Biochem Biophys Res Commun 121:1027–1032.

    CAS  PubMed  Google Scholar 

  • Futagami, S., Suzuki, K., Hiratsuka, T., Shindo, T., Hamamoto, T., Tatsuguchi, A., Ueki, N., Shinji, Y., Kusunoki, M., Wada, K., Miyake, K., Gudis, K., Tsukui, T., and Sakamoto, C. 2006. Celecoxib inhibits Cdx2 expression and prevents gastric cancer in Helicobacter pylori-infected Mongolian gerbils. Digestion 74:187–198.

    CAS  PubMed  Google Scholar 

  • Futagami, S., Suzuki, K., Hiratsuka, T., Shindo, T., Hamamoto, T., Ueki, N., Kusunoki, M., Miyake, K., Gudis, K., Tsukui, T., and Sakamoto, C. 2007. Chemopreventive effect of celecoxib in gastric cancer. Inflammopharmacology 15:1–4.

    CAS  PubMed  Google Scholar 

  • Gasbarrini, A., Carloni, E., Gasbarrini, G., and Menard, A. 2003. Helicobacter pylori and extra-gastric diseases—other Helicobacters. Helicobacter 8(Suppl 1):68–76.

    PubMed  Google Scholar 

  • Geboers, J., Joosens, J., and Kesteloot, H. 1985. Epidemiology of stomach cancer. In: Joossens, J., Hill, M., and Geboers, J., editors. Diet and human carcinogenesis. Amsterdam: Elsevier; pp. 81–95.

    Google Scholar 

  • Goldenring, J. R., and Nomura, S. 2006. Differentiation of the gastric mucosa. III. Animal models of oxyntic atrophy and metaplasia. Am J Physiol Gastrointest Liver Physiol 291:G999–1004.

    CAS  PubMed  Google Scholar 

  • Gottfried, M. R., Washington, K., and Harrell, L. J. 1990. Helicobacter pylori-like microorganisms and chronic active gastritis in ferrets. Am J Gastroenterol 85:813–818.

    CAS  PubMed  Google Scholar 

  • Gualtieri, M., Monzeglio, M. G., and Scanziani, E. 1999. Gastric neoplasia. Vet Clin North Am Small Anim Pract 29:415–440.

    CAS  PubMed  Google Scholar 

  • Hahm, K. B., Song, Y. J., Oh, T. Y., Lee, J. S., Surh, Y. J., Kim, Y. B., Yoo, B. M., Kim, J. H., Han, S. U., Nahm, K. T., Kim, M. W., Kim, D. Y., and Cho, S. W. 2003. Chemoprevention of Helicobacter pylori-associated gastric carcinogenesis in a mouse model: is it possible? J Biochem Mol Biol 36:82–94.

    CAS  PubMed  Google Scholar 

  • Halldorsdottir, A. M., Sigurdardottrir, M., Jonasson, J. G., Oddsdottir, M., Magnusson, J., Lee, J. R., and Goldenring, J. R. 2003. Spasmolytic polypeptide-expressing metaplasia (SPEM) associated with gastric cancer in Iceland. Dig Dis Sci 48:431–441.

    CAS  PubMed  Google Scholar 

  • Handt, L. K., Fox, J. G., Dewhirst, F. E., Fraser, G. J., Paster, B. J., Yan, L. L., Rozmiarek, H., Rufo, R., and Stalis, I. H. 1994. Helicobacter pylori isolated from the domestic cat: public health implications. Infect Immun 62:2367–2374.

    CAS  PubMed  Google Scholar 

  • Handt, L. K., Fox, J. G., Stalis, I. H., Rufo, R., Lee, G., Linn, J., Li, X., and Kleanthous, H. 1995. Characterization of feline Helicobacter pylori strains and associated gastritis in a colony of domestic cats. J Clin Microbiol 33:2280–2289.

    CAS  PubMed  Google Scholar 

  • Haorah, J., Zhou, L., Wang, X., Xu, G., and Mirvish, S. S. 2001. Determination of total N-nitroso compounds and their precursors in frankfurters, fresh meat, dried salted fish, sauces, tobacco, and tobacco smoke particulates. J Agric Food Chem 49:6068–6078.

    CAS  PubMed  Google Scholar 

  • Harper, C. M., Dangler, C. A., Xu, S., Feng, Y., Shen, Z., Sheppard, B., Stamper, A., Dewhirst, F. E., Paster, B. J., and Fox, J. G. 2000. Isolation and characterization of a Helicobacter sp. from the gastric mucosa of dolphins, Lagenorhynchus acutus and Delphinus delphis. Appl Environ Microbiol 66:4751–4757.

    CAS  PubMed  Google Scholar 

  • Harper, C. G., Feng, Y., Xu, S., Taylor, N. S., Kinsel, M., Dewhirst, F. E., Paster, B. J., Greenwell, M., Levine, G., Rogers, A., and Fox, J. G. 2002. Helicobacter cetorum sp. nov., a urease-positive Helicobacter species isolated from dolphins and whales. J Clin Microbiol 40:4536–4543.

    CAS  PubMed  Google Scholar 

  • Harper, C. M., Xu, S., Feng, Y., Dunn, J. L., Taylor, N. S., Dewhirst, F. E., and Fox, J. G. 2002. Identification of novel Helicobacter spp. from a beluga whale. Appl Environ Microbiol 68:2040–2043.

    CAS  PubMed  Google Scholar 

  • Harper, C. G., Xu, S., Rogers, A. B., Feng, Y., Shen, Z., Taylor, N. S., Dewhirst, F. E., Paster, B. J., Miller, M., Hurley, J., and Fox, J. G. 2003. Isolation and characterization of novel Helicobacter spp. from the gastric mucosa of harp seals Phoca groenlandica. Dis Aquat Organ 57:1–9.

    CAS  PubMed  Google Scholar 

  • Harris, C. C. 1996. p53 tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective. Carcinogenesis 17:1187–1198.

    CAS  PubMed  Google Scholar 

  • Harvey, M., McArthur, M. J., Montgomery, C. A., Jr., Butel, J. S., Bradley, A., and Donehower, L. A. 1993. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat Genet 5:225–229.

    CAS  PubMed  Google Scholar 

  • Hickman-Davis, J. M. 2001. Implications of mouse genotype for phenotype. News Physiol Sci 16:19–22.

    CAS  PubMed  Google Scholar 

  • Hirayama, F., Takagi, S., Kusuhara, H., Iwao, E., Yokoyama, Y., and Ikeda, Y. 1996. Induction of gastric ulcer and intestinal metaplasia in mongolian gerbils infected with Helicobacter pylori. J Gastroenterol 31:755–757.

    CAS  PubMed  Google Scholar 

  • Hirose, M., Fukushima, S., Tanaka, H., Asakawa, E., Takahashi, S., and Ito, N. 1993. Carcinogenicity of catechol in F344 rats and B6C3F1 mice. Carcinogenesis 14:525–529.

    CAS  PubMed  Google Scholar 

  • Houghton, J., Stoicov, C., Nomura, S., Rogers, A. B., Carlson, J., Li, H., Cai, X., Fox, J. G., Goldenring, J. R., and Wang, T. C. 2004. Gastric cancer originating from bone marrow-derived cells. Science 306:1568–1571.

    CAS  PubMed  Google Scholar 

  • Huff, J. L., Hansen, L. M., and Solnick, J. V. 2004. Gastric transcription profile of Helicobacter pylori infection in the rhesus macaque. Infect Immun 72:5216–5226.

    CAS  PubMed  Google Scholar 

  • IARC. 1977. N-nitroso-N-methylurea. In: Monographs on the evaluation of carcinogenic risk of chemicals to man. Lyon: IARC; pp. 227–255.

    Google Scholar 

  • Ihrig, M., Whary, M. T., Dangler, C. A., and Fox, J. G. 2005. Gastric Helicobacter infection induces a Th2 phenotype but does not elevate serum cholesterol in mice lacking inducible nitric oxide synthase. Infect Immun 73:1664–1670.

    CAS  PubMed  Google Scholar 

  • Jones, T., and Hunt, R. 1983. Veterinary pathology. Philadelphia: Lea & Febiger.

    Google Scholar 

  • Joossens, J. V., and Geboers, J. 1981. Nutrition and gastric cancer. Proc Nutr Soc 40:37–46.

    CAS  PubMed  Google Scholar 

  • Kang, W., Rathinavelu, S., Samuelson, L. C., and Merchant, J. L. 2005. Interferon gamma induction of gastric mucous neck cell hypertrophy. Lab Invest 85:702–715.

    CAS  PubMed  Google Scholar 

  • Karita, M., Li, Q., Cantero, D., and Okita, K. 1994. Establishment of a small animal model for human Helicobacter pylori infection using germ-free mouse. Am J Gastroenterol 89:208–213.

    CAS  PubMed  Google Scholar 

  • Kawase, S., and Ishikura, H. 1995. Female-predominant occurrence of spontaneous gastric adeno-carcinoma in cotton rats. Lab Anim Sci 45:244–248.

    CAS  PubMed  Google Scholar 

  • Kelley, J. R., and Duggan, J. M. 2003. Gastric cancer epidemiology and risk factors. J Clin Epidemiol 56:1–9.

    PubMed  Google Scholar 

  • Kent, S. P. 1960. Spontaneous and induced malignant neoplasms in monkeys. Ann NY Acad Sci 85:819–827.

    CAS  PubMed  Google Scholar 

  • Kimbrough, R. 1966. Spontaneous malignant gastric tumor in a Rhesus monkey (Macaca mulatta). Arch Pathol 81:343–351.

    CAS  PubMed  Google Scholar 

  • Kleanthous, H., Tibbitts, T., Bakios, T., et al. 1995. In vivo selection of a highly adapted H. pylori isolate and the development of an H. pylori mouse model for studying vaccine efficacy and attenuating lesions. Gut 37:A94.

    Google Scholar 

  • Klein, A., and Palmer, W. 1941. Experimental gastric carcinoma: a critical review with comments on the criteria of induced malignancy. J Natl Cancer Inst 1:559–584.

    CAS  Google Scholar 

  • Kodama, M., Kodama, T., Fukami, H., Ogiu, T., and Kodama, M. 1992. Comparative genetics of host response to N-methyl 1-N′-nitro-N-nitrosoguanidine. I. A lack of tumor production in the glandular stomach of Swiss mouse. Anticancer Res 12:441–449.

    CAS  PubMed  Google Scholar 

  • Kodama, M., Kodama, T., Suzuki, H., and Kondo, K. 1984. Effect of rice and salty rice diets on the structure of mouse stomach. Nutr Cancer 6:135–147.

    CAS  PubMed  Google Scholar 

  • Kogure, K., Sasadaira, H., Kawachi, T., Shimosato, Y., and Tokunaga, A. 1974. Further studies on induction of stomach cancer in hamsters by N-methyl-N′-nitro-N-nitrosoguanidine. Br J Cancer 29:132–142.

    CAS  PubMed  Google Scholar 

  • Kondo, K. 2002. Duodenogastric reflux and gastric stump carcinoma. Gastric Cancer 5:16–22.

    PubMed  Google Scholar 

  • Kondo, K., Kojima, H., Akiyama, S., Ito, K., and Takagi, H. 1995. Pathogenesis of adenocarci-noma induced by gastrojejunostomy in Wistar rats: role of duodenogastric reflux. Carcinogenesis 16:1747–1751.

    CAS  PubMed  Google Scholar 

  • Koyama, Y., Omori, K., Hirota, T., Sano, R., and Ishihara, K. 1976. Leiomyosarcomas of the small intestine induced in dogs by N-methul-N′-nitro-N-nitrosoguanidine. Gann 67:241–251.

    CAS  PubMed  Google Scholar 

  • Kurihara, M., Shirakabe, H., Murakami, T., Yasui, A., and Izumi, T. 1974. A new method for producing adenocarcinomas in the stomach of dogs with N-ethyl-N′-nitro-N-nitrosoguanidine. Gann 65:163–177.

    CAS  PubMed  Google Scholar 

  • Kurt-Jones, E. A., Cao, L., Sandor, F., Rogers, A. B., Whary, M. T., Nambiar, P. R., Cerny, A., Bowen, G., Yan, J., Takaishi, S., Chi, A. L., Reed, G., Houghton, J., Fox, J. G., and Wang, T. C. 2007. Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses. Infect Immun 75:471–480.

    CAS  PubMed  Google Scholar 

  • Kuzushita, N., Rogers, A. B., Monti, N. A., Whary, M. T., Park, M. J., Aswad, B. I., Shirin, H., Koff, A., Eguchi, H., and Moss, S. F. 2005. p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori-infected mice. Gastroenterology 129:1544–1556.

    CAS  PubMed  Google Scholar 

  • Lapin, B. A., and Iakovleva, L. A. 1959. [Tumors of the gastrointestinal tract in monkeys following prolonged intake of cholesterol.]. Arkh Patol 21(10):25–30.

    CAS  PubMed  Google Scholar 

  • La Vecchia, C., Negri, E., Decarli, A., et al. 1987. A case-control study of diet and gastric cancer in northern Italy. Int J Cancer 40:198–205.

    Google Scholar 

  • Lecoindre, P., Chevallier, M., Peyrol, S., Boude, M., Ferrero, R. L., and Labigne, A. 2000. Gastric Helicobacters in cats. J Feline Med Surg 2:19–27.

    CAS  PubMed  Google Scholar 

  • Lee, A. 2000. Animal models of gastroduodenal ulcer disease. Baillieres Best Pract Res Clin Gastroenterol 14:75–96.

    CAS  PubMed  Google Scholar 

  • Lee, A., Fox, J. G., Otto, G., and Murphy, J. 1990. A small animal model of human Helicobacter pylori active chronic gastritis. Gastroenterology 99:1315–1323.

    CAS  PubMed  Google Scholar 

  • Lee, A., Hazell, S. L., O'Rourke, J., and Kouprach, S. 1988. Isolation of a spiral-shaped bacterium from the cat stomach. Infect Immun 56:2843–2850.

    CAS  PubMed  Google Scholar 

  • Lee, A., O'Rourke, J., De Ungria, M. C., Robertson, B., Daskalopoulos, G., and Dixon, M. F. 1997. A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain. Gastroenterology 112:1386–1397.

    CAS  PubMed  Google Scholar 

  • Lingeman, C. H., Garner, F. M., and Taylor, D. O. 1971. Spontaneous gastric adenocarcinomas of dogs: a review. J Natl Cancer Inst 47:137–153.

    CAS  PubMed  Google Scholar 

  • Liu, C., Russell, R. M., and Wang, X. D. 2006. Lycopene supplementation prevents smoke-induced changes in p53, p53 phosphorylation, cell proliferation, and apoptosis in the gastric mucosa of ferrets. J Nutr 136:106–111.

    CAS  PubMed  Google Scholar 

  • Marchetti, M., Arico, B., Burroni, D., Figura, N., Rappuoli, R., and Ghiara, P. 1995. Development of a mouse model of Helicobacter pylori infection that mimics human disease. Science 267:1655–1658.

    CAS  PubMed  Google Scholar 

  • Maronpot, R. R., Flake, G., and Huff, J. 2004. Relevance of animal carcinogenesis findings to human cancer predictions and prevention. Toxicol Pathol 32(Suppl 1):40–48.

    CAS  PubMed  Google Scholar 

  • Marshall, B. J., and Warren, J. R. 1984. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1:1311–1315.

    CAS  PubMed  Google Scholar 

  • Matsukura, N., Morino, K., Ohgaki, H., et al. 1981. Canine gastric carcinoma as an animal model of human gastric carcinoma. Stomach Intest 16:715–722.

    Google Scholar 

  • McCarrison, R. 1915. The pathogenesis of deficiency disease on the occurrence of recently developed cancer of the stomach in a monkey fed on food deficient in vitamins. Indian J Med Res 7:342–345.

    Google Scholar 

  • McClure, H., Chapman, W., Hooper, B., et al. 1978. The digestive system. In: Benirschke, K., Garner, F., and Jones, T., editors. Pathology of laboratory animals. New York: Springer-Verlag; pp. 125–317.

    Google Scholar 

  • McColm, A., Bagshaw, J., O'Malley, C., et al. 1995. Development of a mouse model of gastric colonisation with Helicobacter pylori. Gut 37:A50.

    Google Scholar 

  • Mensinga, T. T., Speijers, G. J., and Meulenbelt, J. 2003. Health implications of exposure to environmental nitrogenous compounds. Toxicol Rev 22:41–51.

    CAS  PubMed  Google Scholar 

  • Ming, S.-C., and Hirota, T. 1998. Malignant epithelial tumors of the stomach. In: Ming, S.-C., and Goldman, H., editors. Pathology of the gastrointestinal tract. Baltimore: Williams & Wilkins; pp. 607–650.

    Google Scholar 

  • Mirvish, S. S. 1971. Kinetics of nitrosamide formation from alkylureas, N-alkylurethans, and alkylguanidines: possible implications for the etiology of human gastric cancer. J Natl Cancer Inst 46:1183–1193.

    CAS  PubMed  Google Scholar 

  • Mirvish, S. S. 1983. The etiology of gastric cancer. Intragastric nitrosamide formation and other theories. J Natl Cancer Inst 71:629–647.

    CAS  PubMed  Google Scholar 

  • Mirvish, S. S. 1995. Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC. Cancer Lett 93:17–48.

    CAS  PubMed  Google Scholar 

  • Mohammadi, M., Redline, R., Nedrud, J., and Czinn, S. 1996. Role of the host in pathogenesis of Helicobacter-associated gastritis: H. felis infection of inbred and congenic mouse strains. Infect Immun 64:238–245.

    CAS  PubMed  Google Scholar 

  • Morris, H. P., Wagner, B. P., Ray, F. E., Snell, K. C., and Stewart, H. L. 1961. Comparative study of cancer and other lesions of rats fed N,N′-2,7-fluorenylene-bisacetamide or N-2-fluorenylacetamide. Natl Cancer Inst Monogr 5:1–53.

    CAS  PubMed  Google Scholar 

  • Moser, A. R., Luongo, C., Gould, K. A., McNeley, M. K., Shoemaker, A. R., and Dove, W. F. 1995. ApcMin: a mouse model for intestinal and mammary tumorigenesis. Eur J Cancer 31A:1061–1064.

    CAS  PubMed  Google Scholar 

  • Moss, S. F., and Malfertheiner, P. 2007. Helicobacter and gastric malignancies. Helicobacter 12(Suppl 1):23–30.

    CAS  PubMed  Google Scholar 

  • Munson, L., Terio, K. A., Worley, M., Jago, M., Bagot-Smith, A., and Marker, L. 2005. Extrinsic factors significantly affect patterns of disease in free-ranging and captive cheetah (Acinonyx jubatus) populations. J Wildl Dis 41:542–548.

    PubMed  Google Scholar 

  • Murray, M., Robinson, P. B., McKeating, F. J., Baker, G. J., and Lauder, I. M. 1972. Primary gastric neoplasia in the dog: a clinico-pathological study. Vet Rec 91:474–479.

    CAS  PubMed  Google Scholar 

  • Nam, K. T., Hahm, K. B., Oh, S. Y., Yeo, M., Han, S. U., Ahn, B., Kim, Y. B., Kang, J. S., Jang, D. D., Yang, K. H., and Kim, D. Y. 2004. The selective cyclooxygenase-2 inhibitor nimesulide prevents Helicobacter pylori-associated gastric cancer development in a mouse model. Clin Cancer Res 10:8105–8113.

    CAS  PubMed  Google Scholar 

  • Newberne, P. M., Charnley, G., Adams, K., Cantor, M., Suphakarn, V., Roth, D., and Schrager, T. F. 1987. Gastric carcinogenesis: a model for the identification of risk factors. Cancer Lett 38:149–163.

    CAS  PubMed  Google Scholar 

  • Newell, D. G., Lee, A., Hawtin, P. R., Hudson, M. J., Stacey, A. R., and Fox, J. 1989. Antigenic conservation of the ureases of spiral- and helical-shaped bacteria colonising the stomachs of man and animals. FEMS Microbiol Lett 53:183–186.

    CAS  PubMed  Google Scholar 

  • Nishikawa, A., Furukawa, F., Imazawa, T., Toyoda, K., Mitsui, M., Hasegawa, T., and Takahashi, M. 1993. Effects of hickory smoke condensate on gastric carcinogenesis in Wistar rats after treat ment with N-methyl-N′-nitro-N-nitrosoguanidine and sodium chloride. Food Chem Toxicol 31:25–30.

    CAS  PubMed  Google Scholar 

  • Nomura, S., Baxter, T., Yamaguchi, H., Leys, C., Vartapetian, A. B., Fox, J. G., Lee, J. R., Wang, T. C., and Goldenring, J. R. 2004. Spasmolytic polypeptide expressing metaplasia to preneo-plasia in H. felis-infected mice. Gastroenterology 127:582–594.

    CAS  PubMed  Google Scholar 

  • Nozaki, K., Shimizu, N., Ikehara, Y., Inoue, M., Tsukamoto, T., Inada, K., Tanaka, H., Kumagai, T., Kaminishi, M., and Tatematsu, M. 2003. Effect of early eradication on Helicobacter pylori-related gastric carcinogenesis in Mongolian gerbils. Cancer Sci 94:235–239.

    CAS  PubMed  Google Scholar 

  • Nozaki, K., Shimizu, N., Inada, K., Tsukamoto, T., Inoue, M., Kumagai, T., Sugiyama, A., Mizoshita, T., Kaminishi, M., and Tatematsu, M. 2002. Synergistic promoting effects of Helicobacter pylori infection and high-salt diet on gastric carcinogenesis in Mongolian gerbils. Jpn J Cancer Res 93:1083–1089.

    CAS  PubMed  Google Scholar 

  • O'Gara, R., and Adamson, R. 1972. Spontaneous and induced neoplasms in nonhuman primates. In: Fiennes, R., editor. Pathology of Simian primates. Part I. Basel: Karger; pp. 190–238.

    Google Scholar 

  • Ohgaki, H., Hasegawa, H., Kusama, K., Morino, K., Matsukura, N., Sato, S., Maruyama, K., and Sugimura, T. 1986. Induction of gastric carcinomas in nonhuman primates by N-ethyl-N′-nitro-N-nitrosoguanidine. J Natl Cancer Inst 77:179–186.

    CAS  PubMed  Google Scholar 

  • Ohgaki, H., Hasegawa, H., Kusama, K., Sato, S., Kawachi, T., Masui, M., Tanabe, K., Kawasaki, I., Hiramatsu, H., and Saito, K. 1984. Squamous cell carcinoma found in the cardiac region of the stomach of an aged orangoutang. Gann 75:415–417.

    CAS  PubMed  Google Scholar 

  • Ohgaki, H., Szentirmay, Z., Take, M., and Sugimura, T. 1989. Effects of 4-week treatment with gastric carcinogens and enhancing agents on proliferation of gastric mucosa cells in rats. Cancer Lett 46:117–122.

    CAS  PubMed  Google Scholar 

  • Ohgaki, H., Tomihari, M., Sato, S., Kleihues, P., and Sugimura, T. 1988. Differential proliferative response of gastric mucosa during carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine in susceptible ACI rats, resistant Buffalo rats, and their hybrid F1 cross. Cancer Res 48:5275–5279.

    CAS  PubMed  Google Scholar 

  • Ohtani, M., Garcia, A., Rogers, A. B., Ge, Z., Taylor, N. S., Xu, S., Watanabe, K., Marini, R. P., Whary, M. T., Wang, T. C., and Fox, J. G. 2007. Protective role of 17β-estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice. Carcinogenesis 28(12):2597–2604.

    CAS  PubMed  Google Scholar 

  • Oshima, H., Oshima, M., Inaba, K., and Taketo, M. M. 2004. Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice. Embo J 23:1669–1678.

    CAS  PubMed  Google Scholar 

  • Otto, G., Hazell, S. H., Fox, J. G., Howlett, C. R., Murphy, J. C., O'Rourke, J. L., and Lee, A. 1994. Animal and public health implications of gastric colonization of cats by Helicobacter- like organisms. J Clin Microbiol 32:1043–1049.

    CAS  PubMed  Google Scholar 

  • Paster, B. J., Lee, A., Fox, J. G., Dewhirst, F. E., Tordoff, L. A., Fraser, G. J., O'Rourke, J. L., Taylor, N. S., and Ferrero, R. 1991. Phylogeny of Helicobacter felis sp. nov., Helicobacter mustelae, and related bacteria. Int J Syst Bacteriol 41:31–38.

    CAS  PubMed  Google Scholar 

  • Peek, R. M., Jr., and Blaser, M. J. 2002. Helicobacter pylori and gastrointestinal tract adenocarci-nomas. Nat Rev Cancer 2:28–37.

    CAS  PubMed  Google Scholar 

  • Perkins, S. E., Fox, J. G., Marini, R. P., Shen, Z., Dangler, C. A., and Ge, Z. 1998. Experimental infection in cats with a cagA+ human isolate of Helicobacter pylori. Helicobacter 3:225–235.

    CAS  PubMed  Google Scholar 

  • Perkins, S. E., Fox, J. G., and Walsh, J. H. 1996. Helicobacter mustelae-associated hypergastrine-mia in ferrets (Mustela putorius furo). Am J Vet Res 57:147–150.

    CAS  PubMed  Google Scholar 

  • Poutahidis, T., Tsangaris, T., Kanakoudis, G., Vlemmas, I., Iliadis, N., and Sofianou, D. 2001. Helicobacter pylori-induced gastritis in experimentally infected conventional piglets. Vet Pathol 38:667–678.

    CAS  PubMed  Google Scholar 

  • Rogers, A. B., and Fox, J. G. 2004. Inflammation and Cancer. I. Rodent models of infectious gastrointestinal and liver cancer. Am J Physiol Gastrointest Liver Physiol 286:G361–366.

    CAS  PubMed  Google Scholar 

  • Rogers, A. B., Taylor, N. S., Whary, M. T., Stefanich, E. D., Wang, T. C., and Fox, J. G. 2005. Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 mice. Cancer Res 65:10709–10715.

    CAS  PubMed  Google Scholar 

  • Ruch, T. 1959. Neoplasia. In: Ruch, T., editor. Diseases of laboratory primates. Philadelphia: Saunders; pp. 529–567.

    Google Scholar 

  • Sakagami, T., Shimoyama, T., O'Rourke, J., et al. 1994. Back to the host: severity of inflammation induced by Helicobacter felis in different strains of mice [abstract]. Am J Gastroenterol 89:1345.

    Google Scholar 

  • Sato, T., Fukuyama, T., Urata, F., et al. 1959. Studies of the causation of gastric cancer. I. Bleeding in the glandular stomach of mice by feeding with highly salted foods and comment on salted foods in Japan. Jap Med J 1835:25.

    Google Scholar 

  • Sawada, Y., Yamamoto, N., Sakagami, T., Fukuda, Y., Shimoyama, T., Nishigami, T., Uematsu, K., and Nakagawa, K. 1999. Comparison of pathologic changes in Helicobacter pylori-infected Mongolian gerbils and humans. J Gastroenterol 34(Suppl 11):55–60.

    PubMed  Google Scholar 

  • Schreiber, H., Nettesheim, P., Lijinsky, W., Richter, C. B., and Walburg, H. E., Jr. 1972. Induction of lung cancer in germfree, specific-pathogen-free, and infected rats by N-nitrosoheptamethyleneimine: enhancement by respiratory infection. J Natl Cancer Inst 4 9:1107–1114.

    CAS  PubMed  Google Scholar 

  • Seoane, A., Bessa, X., Alameda, F., Munne, A., Gallen, M., Navarro, S., O'Callaghan, E., Panades, A., Andreu, M., and Bory, F. 2005. Role of Helicobacter pylori in stomach cancer after partial gastrectomy for benign ulcer disease. Rev Esp Enferm Dig 97:778–785.

    CAS  PubMed  Google Scholar 

  • Seymour, C., Lewis, R. G., Kim, M., Gagnon, D. F., Fox, J. G., Dewhirst, F. E., and Paster, B. J. 1994. Isolation of Helicobacter strains from wild bird and swine feces. Appl Environ Microbiol 60:1025–1028.

    CAS  PubMed  Google Scholar 

  • Sharashidze, L. K., Beniashvili, D., Sherenesheva, N. I., and Turkia, N. G. 1989. Induction of gastric cancer in monkeys by N-methyl-N-nitro-N-nitrosoguanidine (MNNG). Neoplasma 36:129–133.

    CAS  PubMed  Google Scholar 

  • Shimizu, N., Inada, K., Nakanishi, H., Tsukamoto, T., Ikehara, Y., Kaminishi, M., Kuramoto, S., Sugiyama, A., Katsuyama, T., and Tatematsu, M. 1999. Helicobacter pylori infection enhances glandular stomach carcinogenesis in Mongolian gerbils treated with chemical carcinogens. Carcinogenesis 20:669–676.

    CAS  PubMed  Google Scholar 

  • Shimizu, N., Inada, K. I., Tsukamoto, T., Nakanishi, H., Ikehara, Y., Yoshikawa, A., Kaminishi, M., Kuramoto, S., and Tatematsu, M. 1999. New animal model of glandular stomach carcinogene-sis in Mongolian gerbils infected with Helicobacter pylori and treated with a chemical carcinogen. J Gastroenterol 34(Suppl 11):61–66.

    CAS  PubMed  Google Scholar 

  • Shimizu, N., Kaminishi, M., Tatematsu, M., Tsuji, E., Yoshikawa, A., Yamaguchi, H., Aoki, F., and Oohara, T. 1998. Helicobacter pylori promotes development of pepsinogen-altered pyloric glands, a preneoplastic lesion of glandular stomach of BALB/c mice pretreated with N-methyl-N-nitrosourea. Cancer Lett 123:63–69.

    CAS  PubMed  Google Scholar 

  • Shin, V. Y., Wu, W. K., Ye, Y. N., So, W. H., Koo, M. W., Liu, E. S., Luo, J. C., and Cho, C. H. 2004. Nicotine promotes gastric tumor growth and neovascularization by activating extracellular signal-regulated kinase and cyclooxygenase-2. Carcinogenesis 25:2487–2495.

    CAS  PubMed  Google Scholar 

  • Sigaran, M. F., and Con-Wong, R. 1979. Production of proliferation lesions in gastric mucosa of albino mice by oral administration of N-methyl-N′-nitro-N-nitrosoguanidine. Gann 70:343–352.

    CAS  PubMed  Google Scholar 

  • Simpson, K. W., Strauss-Ayali, D., Scanziani, E., Straubinger, R. K., McDonough, P. L., Straubinger, A. F., Chang, Y. F., Domeneghini, C., Arebi, N., and Calam, J. 2000. Helicobacter felis infection is associated with lymphoid follicular hyperplasia and mild gastritis but normal gastric secretory function in cats. Infect Immun 68:779–790.

    CAS  PubMed  Google Scholar 

  • Simpson, K. W., Strauss-Ayali, D., Straubinger, R. K., Scanziani, E., McDonough, P. L., Straubinger, A. F., Chang, Y. F., Esteves, M. I., Fox, J. G., Domeneghini, C., Arebi, N., and Calam, J. 2001. Helicobacter pylori infection in the cat: evaluation of gastric colonization, inflammation and function. Helicobacter 6:1–14.

    CAS  PubMed  Google Scholar 

  • Singer, G. M., and Taylor, H. W. 1976. Carcinogenicity of N′-nitrosonornicotine in Sprague-Dawley rats. J Natl Cancer Inst 57:1275–1276.

    CAS  PubMed  Google Scholar 

  • Sinning, C., Schaefer, N., Standop, J., Hirner, A., and Wolff, M. 2007. Gastric stump carcinoma: epidemiology and current concepts in pathogenesis and treatment. Eur J Surg Oncol 33:133–139.

    CAS  PubMed  Google Scholar 

  • Solnick, J. V., Canfield, D. R., Yang, S., and Parsonnet, J. 1999. Rhesus monkey (Macaca mulatta) model of Helicobacter pylori: noninvasive detection and derivation of specific-pathogen-free monkeys. Lab Anim Sci 49:197–201.

    CAS  PubMed  Google Scholar 

  • Solnick, J. V., Chang, K., Canfield, D. R., and Parsonnet, J. 2003. Natural acquisition of Helicobacter pylori infection in newborn rhesus macaques. J Clin Microbiol 41:5511–5516.

    PubMed  Google Scholar 

  • Solnick, J. V., Fong, J., Hansen, L. M., Chang, K., Canfield, D. R., and Parsonnet, J. 2006. Acquisition of Helicobacter pylori infection in rhesus macaques is most consistent with oral-oral transmission. J Clin Microbiol 44:3799–3803.

    PubMed  Google Scholar 

  • Solnick, J. V., Hansen, L. M., Canfield, D. R., and Parsonnet, J. 2001. Determination of the infectious dose of Helicobacter pylori during primary and secondary infection in rhesus monkeys (Macaca mulatta). Infect Immun 69:6887–6892.

    CAS  PubMed  Google Scholar 

  • Sorbye, H., Guttu, K., Gislason, H., Grong, K., and Svanes, K. 1993. Gastric mucosal injury and associated changes in mucosal blood flow and gastric fluid secretion caused by dimethyl sul-foxide (DMSO) in rats. Dig Dis Sci 38:1243–1250.

    CAS  PubMed  Google Scholar 

  • Sorbye, H., Kvinnsland, S., and Svanes, K. 1994. Effect of salt-induced mucosal damage and healing on penetration of N-methyl-N′-nitro-N-nitrosoguanidine to proliferative cells in the gastric mucosa of rats. Carcinogenesis 15:673–679.

    CAS  PubMed  Google Scholar 

  • Sorbye, H., Maaartmann-Moe, H., and Svanes, K. 1994. Gastric carcinogenesis in rats given hypertonic salt at different times before a single dose of N-methyl-N′-nitro-N-nitrosoguanidine. J Cancer Res Clin Oncol 120:159–163.

    CAS  PubMed  Google Scholar 

  • Sorbye, H., Svanes, C., Stangeland, L., Kvinnsland, S., and Svanes, K. 1988. Epithelial restitution and cellular proliferation after gastric mucosal damage caused by hypertonic NaCl in rats. Virchows Arch A Pathol Anat Histopathol 413:445–455.

    CAS  PubMed  Google Scholar 

  • Squire, R., Goodman, D., Valerio, M., et al. 1978. Tumors. In: Benirschke, K., Garner, F., and Jones, T., editors. Pathology of laboratory animals. New York: Springer-Verlag; pp. 1051–1283.

    Google Scholar 

  • Stenstrom, B., Zhao, C. M., Rogers, A. B., Nilsson, H. O., Sturegard, E., Lundgren, S., Fox, J. G., Wang, T. C., Wadstrom, T., and Chen, D. 2007. Swedish moist snuff accelerates gastric cancer development in Helicobacter pylori-infected wild-type and gastrin transgenic mice. Carcinogenesis 28(9):2041–2046.

    PubMed  Google Scholar 

  • Stewart, H. L., and Hare, W. V. 1950. Variation in susceptibility of the fundic and pyloric portions of the glandular stomach of the rat to induction of neoplasia by 20-methylcholanthrene. Acta Unio Int Contra Cancrum 7:176–177.

    CAS  PubMed  Google Scholar 

  • Stoicov, C., Whary, M., Rogers, A. B., Lee, F. S., Klucevsek, K., Li, H., Cai, X., Saffari, R., Ge, Z., Khan, I. A., Combe, C., Luster, A., Fox, J. G., and Houghton, J. 2004. Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections. J Immunol 173:3329–3336.

    CAS  PubMed  Google Scholar 

  • Straubinger, R. K., Greiter, A., McDonough, S. P., Gerold, A., Scanziani, E., Soldati, S., Dailidiene, D., Dailide, G., Berg, D. E., and Simpson, K. W. 2003. Quantitative evaluation of inflammatory and immune responses in the early stages of chronic Helicobacter pylori infection. Infect Immun 71:2693–2703.

    CAS  PubMed  Google Scholar 

  • Sugihara, H., Tsuchihashi, Y., Hattori, T., Fukuda, M., and Fujita, S. 1985. Cell proliferation and cell loss in intramucosal signet ring cell carcinoma of canine stomachs induced by N-ethyl-N′-nitro-N-nitrosoguanidine. J Cancer Res Clin Oncol 110:87–94.

    CAS  PubMed  Google Scholar 

  • Sugimura, T., and Fujimura, S. 1967. Tumour production in glandular stomach of rat by N-methyl-N′-nitro-N-nitrosoguanidine. Nature 216:943–944.

    CAS  PubMed  Google Scholar 

  • Sugimura, T., and Kawachi, T. 1973. Experimental stomach cancer. Methods Cancer Res 7:245–308.

    CAS  Google Scholar 

  • Sugimura, T., and Kawachi, T. 1978. Experimental stomach carcinogenesis In: Lipkin, M., and Good R., editors. Gastrointestinal tract cancer. New York: Plenum Press; pp. 327–341.

    Google Scholar 

  • Sugimura, T., Tanaka, N., Kawachi, T., Kogure, K., and Fujimura, S. 1971. Production of stomach cancer in dogs by N-methyl-N′-nitro-N-nitrosoguanidine. Gann 62:67.

    CAS  PubMed  Google Scholar 

  • Sugiyama, A., Maruta, F., Ikeno, T., Ishida, K., Kawasaki, S., Katsuyama, T., Shimizu, N., and Tatematsu, M. 1998. Helicobacter pylori infection enhances N-methyl-N-nitrosourea-induced stomach carcinogenesis in the Mongolian gerbil. Cancer Res 58:2067–2069.

    CAS  PubMed  Google Scholar 

  • Sumi, Y., and Miyakawa, M. 1981. Comparative studies on the production of stomach tumors following the intubation of several doses of N-methyl-N′-nitro-N-nitrosoguanidine in germ-free and conventional newborn rats. Gann 72:700–704.

    CAS  PubMed  Google Scholar 

  • Swann, H. M., and Holt, D. E. 2002. Canine gastric adenocarcinoma and leiomyosarcoma: a retrospective study of 21 cases (1986–1999) and literature review. J Am Anim Hosp Assoc 38:157–164.

    PubMed  Google Scholar 

  • Syder, A. J., Oh, J. D., Guruge, J. L., O'Donnell, D., Karlsson, M., Mills, J. C., Bjorkholm, B. M., and Gordon, J. I. 2003. The impact of parietal cells on Helicobacter pylori tropism and host pathology: an analysis using gnotobiotic normal and transgenic mice. Proc Natl Acad Sci USA 100:3467–3472.

    CAS  PubMed  Google Scholar 

  • Szentirmay, Z., Ohgaki, H., Maruyama, K., Esumi, H., Takayama, S., and Sugimura, T. 1990. Early gastric cancer induced by N-ethyl-N′-nitro-N-nitrosoguanidine in a cynomolgus monkey six years after initial diagnosis of the lesion. Jpn J Cancer Res 81:6–9.

    CAS  PubMed  Google Scholar 

  • Tajima, K., and Tominaga, S. 1985. Dietary habits and gastro-intestinal cancers: a comparative case-control study of stomach and large intestinal cancers in Nagoya, Japan. Jpn J Cancer Res 76:705–716.

    CAS  PubMed  Google Scholar 

  • Takahashi, M., and Hasegawa, H. 1986. Enhancing effects of dietary salt on both initiation and promotion stages of rat gastric carcinogenesis. In: Hayashi, Y., Nagao, M., Sugimura, T., Takayama, S., Tomatis, T., et al., editors. Diet, nutrition and cancer. Utrecht: Japan Sci Sco Press; pp. 169–182.

    Google Scholar 

  • Takahashi, M., Kokubo, T., Furukawa, F., Kurokawa, Y., Tatematsu, M., and Hayashi, Y. 1983. Effect of high salt diet on rat gastric carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine. Gann 74:28–34.

    CAS  PubMed  Google Scholar 

  • Tanaka, Y., Osugi, H., Morimura, K., Takemura, M., Ueno, M., Kaneko, M., Fukushima, S., and Kinoshita, H. 2004. Effect of duodenogastric reflux on N-methyl-N′-nitro-N-nitrosoguanidine-induced glandular stomach tumorigenesis in Helicobacter pylori-infected Mongolian gerbils. Oncol Rep 11:965–971.

    CAS  PubMed  Google Scholar 

  • Tatematsu, M., Ogawa, K., Hoshiya, T., Shichino, Y., Kato, T., Imaida, K., and Ito, N. 1992. Induction of adenocarcinomas in the glandular stomach of BALB/c mice treated with N-methyl-N-nitrosourea. Jpn J Cancer Res 83:915–918.

    CAS  PubMed  Google Scholar 

  • Tatematsu, M., Takahashi, M., Fukushima, S., Hananouchi, M., and Shirai, T. 1975. Effects in rats of sodium chloride on experimental gastric cancers induced by N-methyl-N-nitro-N-nitrosoguanidine or 4-nitroquinoline-1-oxide. J Natl Cancer Inst 55:101–106.

    CAS  PubMed  Google Scholar 

  • Tatematsu, M., Takahashi, M., Hananouchi, M., Shirai, T., and Hirose, M. 1976. Protective effect of mucin on experimental gastric cancer induced by N-methyl-N′-nitro-N-nitrosoguanidine plus sodium chloride in rats. Gann 67:223–229.

    CAS  PubMed  Google Scholar 

  • Tatematsu, M., Tsukamoto, T., and Mizoshita, T. 2005. Role of Helicobacter pylori in gastric car-cinogenesis: the origin of gastric cancers and heterotopic proliferative glands in Mongolian gerbils. Helicobacter 10:97–106.

    PubMed  Google Scholar 

  • Tatematsu, M., Yamamoto, M., Iwata, H., Fukami, H., Yuasa, H., Tezuka, N., Masui, T., and Nakanishi, H. 1993. Induction of glandular stomach cancers in C3H mice treated with N-methyl-N-nitrosourea in the drinking water. Jpn J Cancer Res 84:1258–1264.

    CAS  PubMed  Google Scholar 

  • Tatematsu, M., Yamamoto, M., Shimizu, N., Yoshikawa, A., Fukami, H., Kaminishi, M., Oohara, T., Sugiyama, A., and Ikeno, T. 1998. Induction of glandular stomach cancers in Helicobacter pylori-sensitive Mongolian gerbils treated with N-methyl-N-nitrosourea and N-methyl-N′-nitro-N-nitrosoguanidine in drinking water. Jpn J Cancer Res 89:97–104.

    CAS  PubMed  Google Scholar 

  • Tennant, R. W. 2002. The National Center for Toxicogenomics: using new technologies to inform mechanistic toxicology. Environ Health Perspect 110:A8–10.

    CAS  PubMed  Google Scholar 

  • Terio, K. A., Munson, L., Marker, L., Aldridge, B. M., and Solnick, J. V. 2005. Comparison of Helicobacter spp. in Cheetahs (Acinonyx jubatus) with and without gastritis. J Clin Microbiol 43:229–234.

    CAS  PubMed  Google Scholar 

  • Tomita, H., Yamada, Y., Oyama, T., Hata, K., Hirose, Y., Hara, A., Kunisada, T., Sugiyama, Y., Adachi, Y., Linhart, H., and Mori, H. 2007. Development of gastric tumors in Apc(Min/+) mice by the activation of the beta-catenin/Tcf signaling pathway. Cancer Res 67:4079–4087.

    CAS  PubMed  Google Scholar 

  • Touati, E., Michel, V., Thiberge, J. M., Wuscher, N., Huerre, M., and Labigne, A. 2003. Chronic Helicobacter pylori infections induce gastric mutations in mice. Gastroenterology 124:1408–1419.

    CAS  PubMed  Google Scholar 

  • Tsugane, S. 2007. Dietary factors in gastrointestinal tract cancers: an Asian perspective. Acta Oncol 46:405–406.

    Google Scholar 

  • Tsugane, S., Akabane, M., Inami, T., Matsushima, S., Ishibashi, T., Ichinowatari, Y., Miyajima, Y., and Watanabe, S. 1991. Urinary salt excretion and stomach cancer mortality among four Japanese populations. Cancer Causes Control 2:165–168.

    CAS  PubMed  Google Scholar 

  • Tsugane, S., and Sasazuki, S. 2007. Diet and the risk of gastric cancer: review of epidemiological evidence. Gastric Cancer 10:75–83.

    PubMed  Google Scholar 

  • Tsugane, S., Sasazuki, S., Kobayashi, M., and Sasaki, S. 2004. Salt and salted food intake and subsequent risk of gastric cancer among middle-aged Japanese men and women. Br J Cancer 90:128–134.

    CAS  PubMed  Google Scholar 

  • Tuyns, A. J. 1988. Salt and gastrointestinal cancer. Nutr Cancer 11:229–232.

    CAS  PubMed  Google Scholar 

  • Van den Bulck, K., Decostere, A., Baele, M., Driessen, A., Debongnie, J. C., Burette, A., Stolte, M., Ducatelle, R., and Haesebrouck, F. 2005. Identification of non-Helicobacter pylori spiral organisms in gastric samples from humans, dogs, and cats. J Clin Microbiol 43:2256–2260.

    PubMed  Google Scholar 

  • Wakeland, E., Morel, L., Achey, K., Yui, M., and Longmate, J. 1997. Speed congenics: a classic technique in the fast lane (relatively speaking). Immunol Today 18:472–477.

    CAS  PubMed  Google Scholar 

  • Wang, T. C., Dangler, C. A., Chen, D., Goldenring, J. R., Koh, T., Raychowdhury, R., Coffey, R. J., Ito, S., Varro, A., Dockray, G. J., and Fox, J. G. 2000. Synergistic interaction between hyper-gastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology 118:36–47.

    CAS  PubMed  Google Scholar 

  • Warren, J. R. 1984. Spiral bacteria of the gastric antrum. Med J Aust 141:477–478.

    CAS  PubMed  Google Scholar 

  • Watanabe, H., Takahashi, T., Okamoto, T., Ogundigie, P. O., and Ito, A. 1992. Effects of sodium chloride and ethanol on stomach tumorigenesis in ACI rats treated with N-methyl-N′-nitro-N-nitrosoguanidine: a quantitative morphometric approach. Jpn J Cancer Res 83:588–593.

    CAS  PubMed  Google Scholar 

  • Waters, M. D., Olden, K., and Tennant, R. W. 2003. Toxicogenomic approach for assessing toxicant-related disease. Mutat Res 544:415–424.

    CAS  PubMed  Google Scholar 

  • Whary, M. T., and Fox, J. G. 2004. Natural and experimental Helicobacter infections. Comp Med 54:128–158.

    CAS  PubMed  Google Scholar 

  • WHO. 2003. Diet, nutrition and the prevention of chronic diseases. World Health Organ Tech Rep Ser 916:i–viii, 1–149.

    Google Scholar 

  • Yang, K., Edelmann, W., Fan, K., Lau, K., Kolli, V. R., Fodde, R., Khan, P. M., Kucherlapati, R., and Lipkin, M. 1997. A mouse model of human familial adenomatous polyposis. J Exp Zool 277:245–254.

    CAS  PubMed  Google Scholar 

  • You, W. C., Blot, W. J., Chang, Y. S., Ershow, A. G., Yang, Z. T., An, Q., Henderson, B., Xu, G. W., Fraumeni, J. F., Jr., and Wang, T. G. 1988. Diet and high risk of stomach cancer in Shandong, China. Cancer Res 48:3518–3523.

    CAS  PubMed  Google Scholar 

  • Yu, J., Fox, J. G., Blanco, M. C., Yan, L., Correa, P., and Russell, R. M. 1995. Long-term supplementation of canthaxanthin does not inhibit gastric epithelial cell proliferation in Helicobacter mustelae-infected ferrets. J Nutr 125:2493–2500.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

    Arlin B. Rogers & James G. Fox

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  1. Arlin B. Rogers
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Editors and Affiliations

  1. Division of Digestive and Liver Diseases, Columbia University, New York, NY, USA

    Timothy C. Wang (Silberberg Professor of Medicine Chair) (Silberberg Professor of Medicine Chair)

  2. Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

    James G. Fox (Director, Professor) (Director, Professor)

  3. Immunity and Environment Murdoch Childrens Research Institute, Royal Melbourne Hospital Footscray, Melbourne, Australia

    Andrew S. Giraud (Professor and Research Theme Director Infection) (Professor and Research Theme Director Infection)

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Rogers, A.B., Fox, J.G. (2009). Animal Models of Gastric Carcinoma. In: Wang, T.C., Fox, J.G., Giraud, A.S. (eds) The Biology of Gastric Cancers. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69182-4_12

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