Cancer Genetics of Human Gastric Adenocarcinoma

  • Roman GalyshJr.
  • Steven M. Powell


Gastric adenocarcinomas are the most common form of gastric cancer and are usually sporadic in nature with genetic alterations acquired over decades. There are, however, rare inherited gastric cancer predisposition traits such as E-cadherin mutations in familial diffuse gastric cancers as discussed in detail below. The complexity of the genetics involved in human gastric adenocarcinoma is reflected in the temporal, regional, and gender variation in gastric cancer incidence rates. A better understanding of these phenomena through molecular and genetic studies of gastric tum-origenesis will provide important insights into cancer development in general and is anticipated to lead to earlier diagnosis and better management options in combating this devastating cancer. The relative importance of bacterial virulence, environmental, and host factors (e.g., age of acquisition, immune response, acid secretion changes) to the clinical outcome of these infections are currently...


Gastric Cancer Gastric Carcinoma Hepatocyte Growth Factor Gastric Cancer Patient Familial Adenomatous Polyposis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science + Business Media, LLC 2009

Authors and Affiliations

  • Roman GalyshJr.
    • 1
  • Steven M. Powell
    • 2
  1. 1.Gastroenterology Fellow, Department of Medicine, Division of Gastroenterology/ HepatologyUniversity of Virginia Health SystemCharlottesvilleUSA
  2. 2.Division of Gastroenterology/HepatologyUniversity of Virginia Health SystemCharlottesvilleUSA

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