Skip to main content
SpringerLink
Log in
Book cover

The Biology of Gastric Cancers pp 1–24Cite as

Overview and Pathology of Gastric Cancer

  • Chapter

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Bizzozero, G. (1892). Sulle ghiandole tubulari del tubo gastro-enterico e sui rapporti del loro epitelio coll'epitelio di rivestimento della mucosa. Atti della Reale Accademia delle Scienze di Torino. 28:233–51.

    Google Scholar 

  • Blaser, M.J., Perez-Perez, G.I., Kleanthous, H., Cover, T.L., Peek, R.M., Chyou, P.H., Stemmermann, G.N., and Nomura, A. (1995). Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res. 55(10):2111–5.

    CAS  PubMed  Google Scholar 

  • Block, G., Patterson, B., and Subar, A. (1992). Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer. 18(1):1–29.

    Article  CAS  PubMed  Google Scholar 

  • Blot, W.J., Devesa, S.S., Kneller, R.W., and Fraumeni, J.F., Jr. (1991). Rising incidence of adeno-carcinoma of the esophagus and gastric cardia. JAMA. 265(10):1287–9.

    Article  CAS  PubMed  Google Scholar 

  • Brabletz, T., Jung, A., and Kirchner, T. (2002). Beta-catenin and the morphogenesis of colorectal cancer. Virchows Arch. 441(1):1–11.

    Article  CAS  PubMed  Google Scholar 

  • Brabletz, T., Jung, A., Spaderna, S., Hlubek, F., and Kirchner, T. (2005). Opinion: migrating cancer stem cells—an integrated concept of malignant tumour progression. Nat Rev Cancer. 5(9):744–9.

    Article  CAS  PubMed  Google Scholar 

  • Camargo, M.C., Mera, R., Correa, P., Peek, R.M., Jr, Fontham, E.T., Goodman, K.J., Piazuelo, M.B., Sicinschi, L., Zabaleta, J., and Schneider, B.G. (2006). Interleukin-1beta and inter-leukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 15(9):1674–87.

    Article  CAS  PubMed  Google Scholar 

  • Camorlinga-Ponce, M., Torres, J., Perez-Perez, G., Leal-Herrera, Y., Gonzalez-Ortiz, B., Madrazo de la Garza, A., Gomez, A., and Munoz, O. (1998). Validation of a serologic test for the diagnosis of Helicobacter pylori infection and the immune response to urease and CagA in children. Am J Gastroenterol. 93(8):1264–70.

    Article  CAS  PubMed  Google Scholar 

  • Carneiro, F., Oliveira, C., Suriano, G., and Seruca, R. (2007). Molecular pathology of familial gastric cancer. J Clin Pathol. May 18 [Epub ahead of print].

    Google Scholar 

  • Carneiro, F., and Sobrinho-Simoes, M. (2005). Hereditary diffuse gastric cancer: lessons from histopatholgy. Adv Anat Pathol. 12(3):151–2.

    Article  Google Scholar 

  • Charlton, A., Blair, V., Shaw, D., Parry, S., Guilford, P., and Martin, I.G. (2004). Hereditary diffuse gastric cancer: predominance of multiple foci of signet ring cell carcinoma in distal stomach and transitional zone. Gut. 53(6):814–20.

    Article  CAS  PubMed  Google Scholar 

  • Cittelly, D.M., Huertas, M.G., Martinez, J.D., Oliveros, R., Posso, H., Bravo, M.M., and Orozco, O. (2002). Helicobacter pylori genotypes in non atrophic gastritis are different of the found in peptic ulcer, premalignant lesions and gastric cancer in Colombia. Rev Med Chil. 130(2): 143–51. Article in Spanish.

    PubMed  Google Scholar 

  • Correa, P., Haenszel, W., Cuello, C., Tannenbaum, S., and Archer, M. (1975). A model for gastric cancer epidemiology. Lancet. 2(7924):58–60.

    Article  CAS  PubMed  Google Scholar 

  • Correa, P., Piazuelo, M.B., and Camargo, M.C. (2006). Etiopathogenesis of gastric cancer. Scand J Surg. 95(4):218–24.

    CAS  PubMed  Google Scholar 

  • Correa, P., and Stemmermann, G.N. (2005). The saga of gastric corpus atrophy. Pathologica. 97(5):319–22.

    CAS  PubMed  Google Scholar 

  • Devesa, S.S., Blot, W.J., and Fraumeni, J.F., Jr. (1998). Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer. 83(10):2049–53.

    Article  CAS  PubMed  Google Scholar 

  • Dubois, A., and Boren, T. (2007). Helicobacter pylori is invasive and it may be a facultative intra-cellular organism. Cell Microbiol. 9(5):1108–16.

    Article  CAS  PubMed  Google Scholar 

  • El-Zimaity, H.M., Ota, H., Graham, D.Y., Akamatsu, T., and Katsuyama, T. (2002). Patterns of gastric atrophy in intestinal type gastric carcinoma. Cancer. 94(5):1428–36.

    Article  PubMed  Google Scholar 

  • Fearon, E.R., and Vogelstein, B. (1990). A genetic model for colorectal tumorigenesis. Cell. 61(5):759–67.

    Article  CAS  PubMed  Google Scholar 

  • Ferlay, J., Bray, F., Pisani, P., and Parkin, D.M. (2004). GLOBOCAN 2002: cancer incidence, mortality and prevalence worldwide. IARC Cancer Base No. 5, version 2.0. Lyon: IARCPress.

    Google Scholar 

  • Figueiredo, C., Machado, J.C., Pharoah, P., Seruca, R., Sousa, S., Carvalho, R., Capelinha, A.F., Quint, W., Caldas, C., van Doorn, L.J., Carneiro, F., and Sobrinho-Simoes, M. (2002). Helicobacter pylori and interleukin-1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer Inst. 94(22):1680–7.

    CAS  PubMed  Google Scholar 

  • Forman, D., Newell, D.G., Fullerton, F., Yarnell, J.W., Stacey, A.R., Wald, N., and Sitas, F. (1991). Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. BMJ. 302(6788):1302–5.

    Article  CAS  PubMed  Google Scholar 

  • Franco, A.T., Israel, D.A., Washington, M.K., Krishna, U., and Fox, J.G., Rogers, A.B., Neish, A.S., Collier-Hyams, L., Perez-Perez, G.I., Hatakeyama, M., Whitehead, R., Gaus, K., O'Brien, D.P., Romero-Gallo, J., and Peek, R.M., Jr. (2005). Activation of beta-catenin by carcinogenic Helicobacter pylori. Proc Natl Acad Sci USA. 102(30):10646–51.

    Article  CAS  PubMed  Google Scholar 

  • Fuccio, L., Zagari, R.M., Minardi, M.E., and Bazzoli, F. (2007). Systematic review: Helicobacter pylori eradication for the prevention of gastric cancer. Aliment Pharmacol Ther. 25(2):133–41.

    Article  CAS  PubMed  Google Scholar 

  • Fukuda, H., Saito, D., Hayashi, S., Hisai, H., Ono, H., Yoshida, S., Oguro, Y., Noda, T., Sato, T., and Katoh, M. (1995). Helicobacter pylori infection, serum pepsinogen level and gastric cancer: a case-control study in Japan. Jpn J Cancer Res. 86(1):64–71.

    CAS  PubMed  Google Scholar 

  • Ghose, C., Perez-Perez, G.I., Torres, V.J., Crosatti, M., Nomura, A., Peek, R.M., Jr., Cover, T.L., Francois, F., and Blaser, M.J. (2007). Serological assays for identification of human gastric colonization by Helicobacter pylori strains expressing VacA m1 or m2. Clin Vaccine Immunol. 14(4):442–50.

    Article  CAS  PubMed  Google Scholar 

  • Goldenring, J.R., and Nomura, S. (2006). Differentiation of the gastric mucosa III. Animal models of oxyntic atrophy and metaplasia. Am J Physiol Gastrointest Liver Physiol. 291(6):G999–1004.

    Article  CAS  PubMed  Google Scholar 

  • Gonzalez, C.A., Sala, N., and Capella, G. (2002). Genetic susceptibility and gastric cancer risk. Int J Cancer. 100(3):249–60.

    Article  CAS  PubMed  Google Scholar 

  • Goodman, K.J., and Correa, P. (2000). Transmission of Helicobacter pylori among siblings. Lancet. 355(9201):358–62.

    Article  CAS  PubMed  Google Scholar 

  • Goto, Y., Ando, T., Naito, M., Goto, H., and Hamajima, N. (2006). Inducible nitric oxide synthase polymorphism is associated with the increased risk of differentiated gastric cancer in a Japanese population. World J Gastroenterol. 12(39):6361–5.

    CAS  PubMed  Google Scholar 

  • Guilford, P., Hopkins, J., Harraway, J., McLeod, M., McLeod, N., Harawira, P., Taite, H., Scoular, R., Miller, A., and Reeve, A.E. (1998). E-cadherin germline mutations in familial gastric cancer. Nature. 392(6674):402–5.

    Article  CAS  PubMed  Google Scholar 

  • Haenszel, W., and Kurihara, M. (1968). Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States. J Natl Cancer Inst. 40(1):43–68.

    CAS  PubMed  Google Scholar 

  • Hamajima, N., Naito, M., Kondo, T., and Goto, Y. (2006). Genetic factors involved in the development of Helicobacter pylori-related gastric cancer. Cancer Sci. 97(11):1129–38.

    Article  CAS  PubMed  Google Scholar 

  • Hamilton, S.R., Aaltonen, L.A., editors. (2000). WHO classification of tumours. Pathology and genetics of tumours of the digestive system. Lyon: IARCPress.

    Google Scholar 

  • Hansson, L.E., Nyren, O., Hsing, A.W., Bergstrom, R., Josefsson, S., Chow, W.H., Fraumeni, J.F., Jr., and Adami, H.O. (1996). The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N Engl J Med. 335(4):242–9.

    Article  CAS  PubMed  Google Scholar 

  • Hassan, M.I., Aschner, Y., Manning, C.H., Xu, J., and Aschner, J.L. (2003). Racial differences in selected cytokine allelic and genotypic frequencies among healthy, pregnant women in North Carolina. Cytokine. 21(1):10–6.

    Article  CAS  PubMed  Google Scholar 

  • Hirayama, T. (1986). Nutrition and cancer: a large scale cohort study. Prog Clin Biol Res. 206:299–311.

    CAS  PubMed  Google Scholar 

  • Hou, L., El-Omar, E.M., Chen, J., Grillo, P., Rabkin, C.S., Baccarelli, A., Yeager, M., Chanock, S.J., Zatonski, W., Sobin, L.H., Lissowska, J., Fraumeni, J.F., Jr., and Chow, W.H. (2007). Polymorphisms in Th1-type cell-mediated response genes and risk of gastric cancer. Carcinogenesis. 28(1):118–23.

    Article  CAS  PubMed  Google Scholar 

  • Houghton, J., Stoicov, C., Nomura, S., Rogers, A.B., Carlson, J., Li, H., Cai, X., Fox, J.G., Goldenring, J.R., and Wang, T.C. (2004). Gastric cancer originating from bone marrow-derived cells. Science. 306(5701):1568–71.

    Article  CAS  PubMed  Google Scholar 

  • IARC. (1994). Monographs on the evaluation of carcinogenic risks to humans. Schistosomes, liver flukes and Helicobacter pylori. Vol. 61. Lyon: International Agency for Research on Cancer; pp. 177–240.

    Google Scholar 

  • IARC. (2002). Monographs on the evaluation of carcinogenic risk to humans: tobacco smoke and involuntary smoking. Vol. 83. Lyon: International Agency for Research on Cancer.

    Google Scholar 

  • Jarvi, O., and Lauren, P. (1951). On the role of heterotopias of the intestinal epithelium in the pathogenesis of gastric cancer. Acta Pathol Microbiol Scand. 29:26–44.

    Article  CAS  PubMed  Google Scholar 

  • Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J., and Thun, M.J. (2007). Cancer statistics, 2007. CA Cancer J Clin. 57(1):43–66.

    Article  PubMed  Google Scholar 

  • Jin, G., Miao, R., Deng, Y., Hu, Z., Zhou, Y., Tan, Y., Wang, J., Hua, Z., Ding, W., Wang, L., Chen, W., Shen, J., Wang, X., Xu, Y., and Shen, H. (2007a). Variant genotypes and haplotypes of the epidermal growth factor gene promoter are associated with a decreased risk of gastric cancer in a high-risk Chinese population. Cancer Sci. 98(6):864–8.

    Article  CAS  Google Scholar 

  • Jin, G., Wang, L., Chen, W., Hu, Z., Zhou, Y., Tan, Y., Wang, J., Hua, Z., Ding, W., Shen, J., Zhang, Z., Wang, X., Xu, Y., and Shen, H. (2007b). Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population. Int J Cancer. 120(6):1330–5.

    Article  CAS  Google Scholar 

  • Joossens, J.V., Hill, M.J., Elliott, P., Stamler, R., Lesaffre, E., Dyer, A., Nichols, R., and Kesteloot, H. (1996). Dietary salt, nitrate and stomach cancer mortality in 24 countries. European Cancer Prevention (ECP) and the INTERSALT Cooperative Research Group. Int J Epidemiol. 25(3):494–504.

    Article  CAS  PubMed  Google Scholar 

  • Kaise, M., Miwa, J., Suzuki, N., Mishiro, S., Ohta, Y., Yamasaki, T., and Tajiri, H. (2007). Inducible nitric oxide synthase gene promoter polymorphism is associated with increased gastric mRNA expression of inducible nitric oxide synthase and increased risk of gastric carcinoma. Eur J Gastroenterol Hepatol. 19(2):139–45.

    Article  CAS  PubMed  Google Scholar 

  • Kamangar, F., Cheng, C., Abnet, C.C., and Rabkin, C.S. (2006). Interleukin-1B polymorphisms and gastric cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 15(10):1920–8.

    Article  CAS  PubMed  Google Scholar 

  • Kato, I., van Doorn, L.J., Canzian, F., Plummer, M., Franceschi, S., Vivas, J., Lopez, G., Lu, Y., Gioia-Patricola, L., Severson, R.K., Schwartz, A.G., and Munoz, N. (2006a). Host-bacterial interaction in the development of gastric precancerous lesions in a high risk population for gastric cancer in Venezuela. Int J Cancer. 119(7):1666–71.

    Article  CAS  Google Scholar 

  • Kato, M., Asaka, M., Nakamura, T., Azuma, T., Tomita, E., Kamoshida, T., Sato, K., Inaba, T., Shirasaka, D., Okamoto, S., Takahashi, S., Terao, S., Suwaki, K., Isomoto, H., Yamagata, H., Nomura, H., Yagi, K., Sone, Y., Urabe, T., Akamatsu, T., Ohara, S., Takagi, A., Miwa, J., and Inatsuchi, S. (2006b). Helicobacter pylori eradication prevents the development of gastric cancer: results of a long-term retrospective study in Japan. Aliment Pharmacol Ther. 24(Suppl 4):203–6.

    Google Scholar 

  • Kaurah, P., MacMillan, A., Boyd, N., Senz, J., De Luca, A., Chun, N., Suriano, G., Zaor, S., Van Manen, L., Gilpin, C., Nikkel, S., Connolly-Wilson, M., Weissman, S., Rubinstein, W.S., Sebold, C., Greenstein, R., Stroop, J., Yim, D., Panzini, B., McKinnon, W., Greenblatt, M., Wirtzfeld, D., Fontaine, D., Coit, D., Yoon, S., Chung, D., Lauwers, G., Pizzuti, A., Vaccaro, C., Redal, M.A., Oliveira, C., Tischkowitz, M., Olschwang, S., Gallinger, S., Lynch, H., Green, J., Ford, J., Pharoah, P., Fernandez, B., and Huntsman, D. (2007). Founder and recurrent CDH1 mutations in families with hereditary diffuse gastric cancer. JAMA. 297(21):2360–72.

    Article  CAS  PubMed  Google Scholar 

  • Kirchner, T., and Brabletz, T. (2000). Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence. Analogies with embryonic gastrulation. Am J Pathol. 157(4):1113–21.

    CAS  PubMed  Google Scholar 

  • Kolonel, L.N., Nomura, A.M., Hirohata, T., Hankin, J.H., and Hinds, M.W. (1981). Association of diet and place of birth with stomach cancer incidence in Hawaii Japanese and Caucasians. Am J Clin Nutr. 34(11):2478–85.

    CAS  PubMed  Google Scholar 

  • Ladeira, M.S., Bueno, R.C., Dos Santos, B.F., Pinto, C.L., Prado, R.P., Silveira, M.G., Rodrigues, M.A., Bartchewsky, W., Jr., Pedrazzoli, J., Jr., Ribeiro, M.L., and Salvadori, D.M. (2007). Relationship among oxidative DNA damage, gastric mucosal density and the relevance of cagA, vacA and iceA genotypes of Helicobacter pylori. Dig Dis Sci. May 23 [Epub ahead of print].

    Google Scholar 

  • Larsson, S.C., Giovannucci, E., and Wolk, A. (2006). Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis. Gastroenterology. 131(4):1271–83.

    Article  CAS  PubMed  Google Scholar 

  • Lauren, P. (1965). The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification. Acta Pathol Microbiol Scand. 64:31–49.

    CAS  PubMed  Google Scholar 

  • Lee, W.P., Tai, D.I., Lan, K.H., Li, A.F., Hsu, H.C., Lin, E.J., Lin, Y.P., Sheu, M.L., Li, C.P., Chang, F.Y., Chao, Y., Yen, S.H., and Lee, S.D. (2005). The —251T allele of the interleukin-8 promoter is associated with increased risk of gastric carcinoma featuring diffuse-type histopa-thology in Chinese population. Clin Cancer Res. 11(18):6431–41.

    Article  CAS  PubMed  Google Scholar 

  • Li, H.C., Stoicov, C., Rogers, A.B., and Houghton, J. (2006). Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers. World J Gastroenterol. 12(3):363–71.

    PubMed  Google Scholar 

  • Liu, X., Miller, M.J., Joshi, M.S, Thomas, D.D., and Lancaster, J.R., Jr. (1998). Accelerated reaction of nitric oxide with O2 within the hydrophobic interior of biological membranes. Proc Natl Acad Sci USA. 95(5):2175–9.

    Article  CAS  PubMed  Google Scholar 

  • Liu, F., Pan, K., Zhang, X., Zhang, Y., Zhang, L., Ma, J., Dong, C., Shen, L., Li, J., Deng, D., Lin, D., and You, W. (2006). Genetic variants in cyclooxygenase-2: expression and risk of gastric cancer and its precursors in a Chinese population. Gastroenterology. 130(7):1975–84.

    Article  CAS  PubMed  Google Scholar 

  • Lu, W., Pan, K., Zhang, L., Lin, D., Miao, X., and You, W. (2005a). Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population. Carcinogenesis. 26(3):631–6.

    Article  CAS  Google Scholar 

  • Lu, Y., Xu, Y.C., Shen, J., Yu, R.B., Niu, J.Y., Guo, J.T., Hu, X., and Shen, H.B. (2005b). E-cadherin gene C-160A promoter polymorphism and risk of non-cardia gastric cancer in a Chinese population. World J Gastroenterol. 11(1):56–60.

    Google Scholar 

  • Lunet, N., Valbuena, C., Vieira, A.L., Lopes, C., Lopes, C., David, L., Carneiro, F., and Barros, H. (2007). Fruit and vegetable consumption and gastric cancer by location and histological type: case-control and meta-analysis. Eur J Cancer Prev. 16(4):312–27.

    Article  PubMed  Google Scholar 

  • Mannick, E.E., Bravo, L.E., Zarama, G., Realpe, J.L., Zhang, X.J., Ruiz, B., Fontham, E.T., Mera, R., Miller, M.J., and Correa, P. (1996). Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants. Cancer Res. 56(14):3238–43.

    CAS  PubMed  Google Scholar 

  • Medina-Franco, H., Barreto-Zuniga, R., and Garcia-Alvarez, M.N. (2007a). Preemptive total gastrectomy for hereditary gastric cancer. J Gastrointest Surg. 11(3):314–7.

    Article  Google Scholar 

  • Medina-Franco, H., Medina, A.R., Vizcaino, G., and Medina-Franco, J.L. (2007b). Single nucle-otide polymorphisms in the promoter region of the E-cadherin gene in gastric cancer: case-control study in a young Mexican population. Ann Surg Oncol. 14(8):2246–9.

    Article  Google Scholar 

  • Mirvish, S.S. (1995). Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC. Cancer Lett. 93(1):17–48.

    Article  CAS  PubMed  Google Scholar 

  • Necchi, V., Candusso, M.E., Tava, F., Luinetti, O., Ventura, U., Fiocca, R., Ricci, V., and Solcia, E. (2007). Intracellular, intercellular, and stromal invasion of gastric mucosa, preneoplastic lesions, and cancer by Helicobacter pylori. Gastroenterology. 132(3):1009–23.

    Article  CAS  PubMed  Google Scholar 

  • Nishino, Y., Inoue, M., Tsuji, I., Wakai, K., Nagata, C., Mizoue, T., Tanaka, K., and Tsugane, S., and Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan. (2006). Tobacco smoking and gastric cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. Jpn J Clin Oncol. 36(12):800–7.

    Article  PubMed  Google Scholar 

  • Nomura, A., Stemmermann, G.N., Chyou, P.H., Kato, I., Perez-Perez, G.I., and Blaser, M.J. (1991). Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med. 325(16):1132–6.

    Article  CAS  PubMed  Google Scholar 

  • Norton, J.A., Ham, C.M., Dam, J.V., Jeffrey, R.B., Longacre, T.A., Huntsman, D.G., Chun, N., Kurian, A.W., and Ford, J.M. (2007). CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancer. Ann Surg. 245(6):873–9.

    Article  PubMed  Google Scholar 

  • Oda, I., Saito, D., Tada, M., Iishi, H., Tanabe, S., Oyama, T., Doi, T., Otani, Y., Fujisaki, J., Ajioka, Y., Hamada, T., Inoue, H., Gotoda, T., and Yoshida, S. (2006). A multicenter retrospective study of endoscopic resection for early gastric cancer. Gastric Cancer. 9(4):262–70.

    Article  PubMed  Google Scholar 

  • Ogura, M., Yamaji, Y., Hikiba, Y., Maeda, S., Matsumura, M., Okano, K., Sassa, R., Yoshida, H., Kawabe, T., and Omata, M. (2006). Gastric cancer among peptic ulcer patients: retrospective, long-term follow-up. Dig Liver Dis. 38(11):811–4.

    Article  CAS  PubMed  Google Scholar 

  • Ohata, H., Kitauchi, S., Yoshimura, N., Mugitani, K., Iwane, M., Nakamura, H., Yoshikawa, A., Yanaoka, K., Arii, K., Tamai, H., Shimizu, Y., Takeshita, T., Mohara, O., and Ichinose, M. (2004). Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer. Int J Cancer. 109(1):138–43.

    Article  CAS  PubMed  Google Scholar 

  • Parkin, D.M., Bray, F., Ferlay, J., and Pisani, P. (2005). Global cancer statistics, 2002. CA Cancer J Clin. 55(2):74–108.

    Article  PubMed  Google Scholar 

  • Parsonnet, J., Friedman, G.D., Orentreich, N., and Vogelman, H. (1997). Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut. 40(3):297–301.

    CAS  PubMed  Google Scholar 

  • Peek, R.M., Jr., and Crabtree, J.E. (2006). Helicobacter infection and gastric neoplasia. J Pathol. 208(2):233–48.

    Article  CAS  PubMed  Google Scholar 

  • Piazuelo, M.B., Haque, S., Delgado, A., Du, J.X., Rodriguez, F., and Correa, P. (2004). Phenotypic differences between esophageal and gastric intestinal metaplasia. Mod Pathol. 17(1):62–74.

    Article  PubMed  Google Scholar 

  • Pignatelli, B., Bancel, B., Esteve, J., Malaveille, C., Calmels, S., Correa, P., Patricot, L.M., Laval, M., Lyandrat, N., and Ohshima, H. (1998). Inducible nitric oxide synthase, anti-oxidant enzymes and Helicobacter pylori infection in gastritis and gastric precancerous lesions in humans. Eur J Cancer Prev. 7(6):439–47.

    Article  CAS  PubMed  Google Scholar 

  • Pignatelli, B., Bancel, B., Plummer, M., Toyokuni, S., Patricot, L.M., and Ohshima, H. (2001). Helicobacter pylori eradication attenuates oxidative stress in human gastric mucosa. Am J Gastroenterol. 96(6):1758–66.

    Article  CAS  PubMed  Google Scholar 

  • Pinto-Correia, A.L., Sousa, H., Fragoso, M., Moreira-Dias, L., Lopes, C., Medeiros, R., and Dinis-Ribeiro, M. (2006). Gastric cancer in a Caucasian population: role of pepsinogen C genetic variants. World J Gastroenterol. 12(31):5033–6.

    CAS  PubMed  Google Scholar 

  • Powell, J., and McConkey, C.C. (1992). The rising trend in esophageal adenocarcinoma and gastric cardia. Eur J Cancer Prev. 1(3):265–9.

    Article  CAS  PubMed  Google Scholar 

  • Quiroga, A.J., Cittelly, D.M., and Bravo, M.M. (2005). BabA2, oipA and cagE Helicobacter pylori genotypes in Colombian patients with gastroduodenal diseases. Biomedica. 25(3):325–34. Article in Spanish.

    PubMed  Google Scholar 

  • Rugge, M., Correa, P., Dixon, M.F., Hattori, T., Leandro, G., Lewin, K., Riddell, R.H., Sipponen, P., and Watanabe, H. (2000). Gastric dysplasia: the Padova international classification. Am J Surg Pathol. 24(2):167–76.

    Article  CAS  PubMed  Google Scholar 

  • Rugge, M., Nitti, D., Farinati, F., di Mario, F., and Genta, R.M. (2005). Non-invasive neoplasia of the stomach. Eur J Gastroenterol Hepatol. 17(11):1191–6.

    Article  PubMed  Google Scholar 

  • Sano, T., and Hollowood, A. (2006). Early gastric cancer: diagnosis and less invasive treatments. Scand J Surg. 95(4):249–55.

    CAS  PubMed  Google Scholar 

  • Savage, S.A., Abnet, C.C., Mark, S.D., Qiao, Y.L., Dong, Z.W., Dawsey, S.M., Taylor, P.R., and Chanock, S.J. (2004). Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocar-cinoma and esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 13(12):2251–7.

    CAS  PubMed  Google Scholar 

  • Semino-Mora, C., Doi, S.Q., Marty, A., Simko, V., Carlstedt, I., and Dubois, A. (2003). Intracellular and interstitial expression of Helicobacter pylori virulence genes in gastric pre-cancerous intestinal metaplasia and adenocarcinoma. J Infect Dis. 187(8):1165–77.

    Article  CAS  PubMed  Google Scholar 

  • Sicinschi, L.A., Lopez-Carrillo, L., Camargo, M.C., Correa, P., Sierra, R.A., Henry, R.R., Chen, J., Zabaleta, J., Piazuelo, M.B., and Schneider, B.G. (2006). Gastric cancer risk in a Mexican population: role of Helicobacter pylori CagA positive infection and polymorphisms in inter-leukin-1 and -10 genes. Int J Cancer. 118(3):649–57.

    Article  CAS  PubMed  Google Scholar 

  • Siewert, J.R., and Stein, H.J. (1996). Adenocarcinoma of the gastroesophageal junction. Classification, pathology and extent of resection. Dis Esophagus. 9:173–182.

    Google Scholar 

  • Siewert, J.R., and Stein, H.J. (1998). Classification of adenocarcinoma of the oesophagogastric junction. Br J Surg. 85(11):1457–9.

    Article  CAS  PubMed  Google Scholar 

  • Silva, F., Carvalho, F., Peixoto, A., Seixas, M., Almeida, R., Carneiro, F., Mesquita, P., Figueiredo, C., Nogueira, C., Swallow, D.M., Amorim, A., and David, L. (2001). MUC1 gene polymorphism in the gastric carcinogenesis pathway. Eur J Hum Genet. 9(7):548–52.

    Article  CAS  PubMed  Google Scholar 

  • Silva, F., Carvalho, F., Peixoto, A., Teixeira, A., Almeida, R., Reis, C., Bravo, L.E., Realpe, L., Correa, P., and David, L. (2003). MUC1 polymorphism confers increased risk for intestinal metaplasia in a Colombian population with chronic gastritis. Eur J Hum Genet. 11(5):380–4.

    Article  CAS  PubMed  Google Scholar 

  • Sipponen, P. (1995). Helicobacter pylori: a cohort phenomenon. Am J Surg Pathol. 19(Suppl 1): S30–6.

    Article  PubMed  Google Scholar 

  • Sipponen, P., Helske, T., Jarvinen, P., Hyvarinen, H., Seppala, K., and Siurala, M. (1994). Fall in the prevalence of chronic gastritis over 15 years: analysis of outpatient series in Finland from 1977, 1985, and 1992. Gut. 35(9):1167–71.

    Article  CAS  PubMed  Google Scholar 

  • Smith, M.G., Hold, G.L., Tahara, E., and El-Omar, E.M. (2006). Cellular and molecular aspects of gastric cancer. World J Gastroenterol. 12(19):2979–90.

    CAS  PubMed  Google Scholar 

  • Tan, Y.K., and Fielding, J.W. (2006). Early diagnosis of early gastric cancer. Eur J Gastroenterol Hepatol. 18(8):821–9.

    Article  PubMed  Google Scholar 

  • Tang, W.Y., Wang, L., Li, C., Hu, Z.B., Chen, R., Zhu, Y.J., Shen, H.B., Wei, Q.Y., and Zhou, J.W. (2007). Identification and functional characterization of J WA polymorphisms and their association with risk of gastric cancer and esophageal squamous cell carcinoma in a Chinese population. J Toxicol Environ Health A. 70(11):885–94.

    Article  CAS  PubMed  Google Scholar 

  • Tarpila, S., Telkka, A., and Siurala, M. (1969). Ultrastructure of various metaplasias of the stomach. Acta Pathol Microbiol Scand. 77(2):187–95.

    Article  CAS  PubMed  Google Scholar 

  • Tatemichi, M., Sawa, T., Gilibert, I., Tazawa, H., Katoh, T., and Ohshima, H. (2005). Increased risk of intestinal type of gastric adenocarcinoma in Japanese women associated with long forms of CCTTT pentanucleotide repeat in the inducible nitric oxide synthase promoter. Cancer Lett. 217(2):197–202.

    Article  CAS  PubMed  Google Scholar 

  • Tham, K.T., Peek, R.M., Jr., Atherton, J.C., Cover, T.L., Perez-Perez, G.I., Shyr, Y., and Blaser, M.J. (2001). Helicobacter pylori genotypes, host factors, and gastric mucosal histopathology in peptic ulcer disease. Hum Pathol. 32(3):264–73.

    Article  CAS  PubMed  Google Scholar 

  • Tsugane, S. (2005). Salt, salted food intake, and risk of gastric cancer: epidemiologic evidence. Cancer Sci. 96(1):1–6.

    Article  CAS  PubMed  Google Scholar 

  • Tsugane, S, and Sasazukiv, S. (2007). Diet and the risk of gastric cancer: review of epidemiological evidence. Gastric Cancer. 10(2):75–83.

    Article  PubMed  Google Scholar 

  • Uemura, N., Okamoto, S., Yamamoto, S., Matsumura, N., Yamaguchi, S., Yamakido, M., Taniyama, K., Sasaki, N., and Schlemper, R.J. (2001). Helicobacter pylori infection and the development of gastric cancer. N Engl J Med. 345(11):784–9.

    Article  CAS  PubMed  Google Scholar 

  • Wang, L., Ke, Q., Chen, W., Wang, J., Tan, Y., Zhou, Y., Hua, Z., Ding, W., Niu, J., Shen, J., Zhang, Z., Wang, X., Xu, Y., and Shen, H. (2007a). Polymorphisms of MTHFD, plasma homocysteine levels, and risk of gastric cancer in a high-risk Chinese population. Clin Cancer Res. 13(8):2526–32.

    Article  CAS  Google Scholar 

  • Wang, P., Xia, H.H., Zhang, J.Y., Dai, L.P., Xu, X.Q., and Wang, K.J. (2007b). Association of inter-leukin-1 gene polymorphisms with gastric cancer: a meta-analysis. Int J Cancer. 120(3):552–62.

    Article  CAS  Google Scholar 

  • Warren, J.R., and Marshall, B.J. (1983). Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. (8336):1273–5.

    Google Scholar 

  • Watanabe, T., Tada, M., Nagai, H., Sasaki, S., and Nakao, M. (1998). Helicobacter pylori infection induces gastric cancer in mongolian gerbils. Gastroenterology. 115(3):642–8.

    Article  CAS  PubMed  Google Scholar 

  • Whary, M.T., and Fox, J.G. (2004). Th1-mediated pathology in mouse models of human disease is ameliorated by concurrent Th2 responses to parasite antigens. Curr Top Med Chem. 4(5):531–8.

    Article  CAS  PubMed  Google Scholar 

  • Whary, M.T., Sundina, N., Bravo, L.E., Correa, P., Quinones, F., Caro, F., and Fox, J.G. (2005). Intestinal helminthiasis in Colombian children promotes a Th2 response to Helicobacter pylori: possible implications for gastric carcinogenesis. Cancer Epidemiol Biomarkers Prev. 14(6):1464–9.

    Article  CAS  PubMed  Google Scholar 

  • Wong, B.C., Lam, S.K., Wong, W.M., Chen, J.S., Zheng, T.T., Feng, R.E., Lai, K.C., Hu, W.H., Yuen, S.T., Leung, S.Y., Fong, D.Y., Ho, J., Ching, C.K., Chen, J.S., and China Gastric Cancer Study Group. (2004). Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA. 291(2):187–94.

    Article  CAS  PubMed  Google Scholar 

  • Yamaguchi, H., Goldenring, J.R., Kaminishi, M., and Lee, J.R. (2002). Identification of spasmolytic polypeptide expressing metaplasia (SPEM) in remnant gastric cancer and surveillance postgastrectomy biopsies. Dig Dis Sci. 47(3):573–8.

    Article  PubMed  Google Scholar 

  • Yasui, W., Sentani, K., Motoshita, J., and Nakayama, H. (2006). Molecular pathobiology of gastric cancer. Scand J Surg. 95(4):225–31.

    CAS  PubMed  Google Scholar 

  • Zabaleta, J., Schneider, B.G., Ryckman, K., Hooper, P.F., Camargo, M.C., Piazuelo, M.B., Sierra, R.A., Fontham, E.T.H., Correa, P., Williams, S.M., and Ochoa, A.C. (2008). Ethnic differences in cytokine gene polymorphisms: potential implications for cancer development. Cancer Immunol Immunother. 57(1):107–14.

    Article  CAS  PubMed  Google Scholar 

  • Zhou, Y., Li, N., Zhuang, W., Liu, G.J., Wu, T.X., Yao, X., Du, L., Wei, M.L., and Wu, X.T. (2007). P53 codon 72 polymorphism and gastric cancer: a meta-analysis of the literature. Int J Cancer. 121(7):1481–6.

    Article  CAS  PubMed  Google Scholar 

  • Zintzaras, E. (2006). Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis. J Hum Genet. 51(7):618–24.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical School, Nashville, TN, USA

    Pelayo Correa, M. Constanza Camargo & M. Blanca Piazuelo

Authors
  1. Pelayo Correa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Constanza Camargo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Blanca Piazuelo
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Digestive and Liver Diseases, Columbia University, New York, NY, USA

    Timothy C. Wang (Silberberg Professor of Medicine Chair) (Silberberg Professor of Medicine Chair)

  2. Division of Comparative Medicine, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

    James G. Fox (Director, Professor) (Director, Professor)

  3. Immunity and Environment Murdoch Childrens Research Institute, Royal Melbourne Hospital Footscray, Melbourne, Australia

    Andrew S. Giraud (Professor and Research Theme Director Infection) (Professor and Research Theme Director Infection)

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer Science + Business Media, LLC

About this chapter

Cite this chapter

Correa, P., Camargo, M.C., Piazuelo, M.B. (2009). Overview and Pathology of Gastric Cancer. In: Wang, T.C., Fox, J.G., Giraud, A.S. (eds) The Biology of Gastric Cancers. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69182-4_1

Download citation

Publish with us

Policies and ethics

Search

Navigation