The Role of Cyclic AMP in Regulating the Androgen Receptor

  • Marianne D. Sadar


The androgen receptor (AR) is suggested to play a predominant role in the recurrence of prostate cancer in patients receiving androgen ablation therapy. In the absence of androgens, the AR is activated by compounds that increase cyclic adenosine 3′,5′-monophosphate (cAMP) and stimulate cAMP-dependent protein kinase (PKA) activity in prostate cancer cells. Thus cross-talk between AR and cAMP/PKA pathways is suspected to be involved in the mechanism underlying castration-recurrent prostate cancer. Elucidation of the molecular mechanism(s) of how the AR can be activated by alternative pathways such as cAMP/PKA in the absence of androgen may yield new therapeutic targets for the improved clinical management of advanced prostate cancer.


Prostate Cancer Androgen Receptor Prostate Cancer Cell Adenylyl Cyclase LNCaP Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



I apologize to those authors whose work were inadvertently overlooked or could not be included due to limitations of space. Thank you to Dr. Joanne Johnson for helping prepare the manuscript. This work was supported by the National Institutes of Health CA105304 and the Canadian Institutes for Health Research MOP79308.


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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Genome Sciences CenterBC Cancer AgencyVancouverCanada

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