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Biorelevant Dissolution Media

  • ANETTE MüLLERTZ
Part of the Biotechnology: Pharmaceutical Aspects book series (PHARMASP, volume VI)

Abstract

Oral administration is the most convenient way to deliver drugs, and therefore the most preferred. However, the oral route is very complex based on the physiological conditions encountered by the drug as it passes from the mouth to the absorptive sites in the intestine. When moving from the stomach through the pylorus into the small intestine, the drug will meet a rapidly changing environment including bile and pancreatic secretions which will introduce different enzymes and surface active bile components, and increase in pH from acidic to neutral. Physiological factors such as the rate of gastric emptying, intestinal motility, blood flow, as well as volume, composition and pH of alimentary secretions are known to impact the rate and/or extent of drug absorption. The basic parameters determining the absorption of a drug compound after oral administration are its solubility and permeability in the conditions associated with the gastrointestinal (GI) tract.

Keywords

Bile Acid Bile Salt Dissolution Medium Lipid Digestion Lipolysis Product 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2007

Authors and Affiliations

  • ANETTE MüLLERTZ
    • 1
  1. 1.Department of Pharmaceutics and Analytical ChemistryThe Faculty of Pharmaceutical Sciences, University of CopenhagenCopenhagen

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