Solvent Systems for Crystallization and Polymorph Selection

Part of the Biotechnology: Pharmaceutical Aspects book series (PHARMASP, volume VI)


Crystallization plays an important role in the synthesis, scale-up, processing, formulation, and stability of active pharmaceutical ingredients (API) (Rodríguez-Hornedo and Murphy, 1999; Shekunov and York, 2000; Rodríguez- Hornedo and Sinclair, 2002). Crystallization from solvent is a particularly important process, as this is the primary means of purification during the intermediate and final stages of drug synthesis. Moreover, solution crystallization determines the final solid-state modification of the API namely polymorphs, solvates, and hydrates.


Nucleation Rate Growth Unit Stable Polymorph Intrinsic Dissolution Rate Relative Thermodynamic Stability 


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© Springer 2007

Authors and Affiliations

    • 1
    • 1
    • 2
    • 2
    • 2
  1. 1.Department of Pharmaceutical Sciences, College of PharmacyUniversity of MichiganAnn ArborUSA
  2. 2.Materials Science, Research Formulations, Pfizer Global Research and Development, Ann Arbor LaboratoriesAnn ArborUSA

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