Pharmaceutical Solvents for Pulmonary Drug Delivery

Part of the Biotechnology: Pharmaceutical Aspects book series (PHARMASP, volume VI)


It must first be recognized that formulating compounds and delivering them as aerosols is complex. Not only does it involve the formulation of a stable solution or suspension in a medium (propellant) that is not as well characterized as other systems, but the resultant system is also subject to performance limitations. In order to efficiently reach the lung, the formulation must be atomized into particles having aerodynamic sizes between approximately 1 and 5 microns. Due to these particle size constraints, as well as inhalation toxicology concerns, the range of possible excipients to choose from during the formulation phase is substantially reduced. Additionally, limiting the concentration of excipients in a formulation is crucial for maintaining adequate aerosol performance. Thus, given the complexity of this relationship, formulating aerosols is a challenging endeavor.


Beclomethasone Dipropionate Dose Inhaler Benzalkonium Chloride Mass Median Aerodynamic Diameter Chronic Obstructive Pulmonary Disorder 
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© Springer 2007

Authors and Affiliations

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    • 1
  1. 1.College of PharmacyUniversity of ArizonaTucsonUSA

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