Pharmaceutical Solvents as Vehicles for Topical Dosage Forms

Part of the Biotechnology: Pharmaceutical Aspects book series (PHARMASP, volume VI)


The selection of a vehicle can dramatically affect delivery and consequently efficacy of topical preparations. In terms of transdermal delivery, where delivering therapeutic agents for systemic effects is desired, solvents and co-solvent systems are widely used to improve both the amount and range of drugs that can be administered at therapeutic levels through the skin. Vehicles used in transdermal systems, such as patches, have recently been reviewed (Williams, 2003). In contrast, the focus of this chapter is on the use of solvents in topical dosage forms, i.e. preparations intended for a local or regional effect on the skin.


Stratum Corneum Propylene Glycol Contact Dermatitis Allergic Contact Dermatitis Topical Formulation 
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Copyright information

© Springer 2007

Authors and Affiliations

    • 1
  1. 1.Professor of Pharmaceutics, School of PharmacyUniversity of ReadingReadingUK

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