Abstract
“Parenteral” is defined1 as “situated or occurring outside the intestine, and especially introduced otherwise than by way of the intestines”—pertaining to essentially any administration route other than enteral. This field is obviously too broad for an adequate focus in one book, let alone one chapter. Many have nonetheless used the term synonymously with injectable drug delivery. We restrict ourselves to this latter usage. This would thus include intravenous, intramuscular, subcutaneous, intrathecal, and subdural injection. In this chapter we discuss the theoretical and practical aspects of solubilizing small molecules for injectable formulation development and will examine the role of surfactants and other excipients in more recent parenteral delivery systems such as liposomes, solid-drug nanoparticles and particulate carriers.
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KIPP, J.E. (2007). Solubilizing Systems for Parenteral Formulation Development—Small Molecules. In: Augustijns, P., Brewster, M.E. (eds) Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics. Biotechnology: Pharmaceutical Aspects, vol VI. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69154-1_10
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DOI: https://doi.org/10.1007/978-0-387-69154-1_10
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