The Biological Clock in Inflammation and Sleep Switch Alterations
The word inflammation derives from Latin inflammare, meaning to set in flame, and signifies the heat and redness related to an increased blood flow and vasodilation in the affected tissue. Although vasodilation, edema, and extravasation of white blood cells are the hallmarks of inflammation, its definition has become broader and has been more loosely applied to tissue reactions to injuries. With the discovery of molecules that mediate inflammation and, in particular, the extensive number of cytokines that regulate the cellular response to inflammation, an inflammatory component is now frequently ascribed to neurodegenerative diseases that were traditionally considered as noninflammatory. This is due to the production of proinflammatory cytokines in activated microglial cells and astrocytes in such diseases. The classical hallmarks of inflammation are, however, lacking.
KeywordsCircadian Rhythm Lateral Hypothalamus Dorsal Raphe Nucleus Suprachiasmatic Nucleus Biological Clock
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- Florenzano, F., and Bentivoglio, M. (2000) Degranulation, density, and distribution of mast cells in the rat thalamus: A light and electron microscopic study in basal conditions and after intracerebroventricular administration of nerve growth factor. J Comp Neurol 424, 651–669.PubMedCrossRefGoogle Scholar
- Gonzalez-Hernandez, T., Afonso-Oramas, D., Cruz-Muros, I., Barroso-Chinea, P., Abreu, P., del Mar Perez-Delgado, M., Rancel-Torres, N., and del Carmen Gonzalez, M. (2006) Interleukin-6 and nitric oxide synthase expression in the vasopressin and corticotrophinreleasing factor systems of the rat hypothalamus. J Histochem Cytochem 54, 427–441.PubMedCrossRefGoogle Scholar
- Maier, J., Kincaid, C., Pagenstecher, A., and Campbell, I.L. (2002) Regulation of signal transducer and activator of transcription and suppressor of cytokine-signaling gene expression in the brain of mice with astrocyte-targeted production of interleukin-12 or experimental autoimmune encephalomyelitis. Am J Pathol 160, 271–288.PubMedGoogle Scholar
- Sadki, A., Bentivoglio, M., Kristensson, K., and Nygard, M. (2006) Suppressors, receptors and effects of cytokines on the aging mouse biological clock. Neurobiol Aging. Google Scholar