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Changes in Sleep and Behavior Following Experimental Immune Stimulation Using Bacterial Endotoxin in Humans

  • Andreas Schuld
  • Monika Haack
  • Janet Mullington
  • Thomas Pollmächer

Abstract

During acute or chronic infection and inflammation complex changes in a variety of physiological systems occur. In addition to changes in temperature or the induction of fever also behavioral changes like tiredness, flu-like symptoms and impaired concentration are common. During the last 20 to 30 years there is rapidly growing interest and also knowledge about the underlying mechanisms: One of the first important findings was the observation, that the hypothalamo-pituitary-adrenal (HPA) system is stimulated following the peripheral administration of interleukin-1 (IL-1) (Besedovsky, del Rey, Sorkin, and Dinarello 1986). After this basic finding in psychoneuroimmunological research further studies focused on the inflammatory cytokines such as IL-1 as major components in the interaction of peripheral immune function and central nervous system (CNS): These peptides belong to the huge number of cytokines which are involved in this brain-immune interaction (see Hopkins and Rothwell 1995; Rothwell and Hopkins 1995). In human research mainly cytokines of the cytokine families of interleukins, interferons (IFN), or the tumor necrosis factor (TNF) family have been investigated.

Keywords

Juvenile Rheumatoid Arthritis Bacterial Endotoxin Sickness Behavior Central Nervous System Function Soluble Tumor Necrosis Factor Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Besedovsky, H., del Rey, A., Sorkin, E., and Dinarello, C.A. (1986). Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233, 652–654.PubMedCrossRefGoogle Scholar
  2. Dantzer, R. (2001). Cytokine-induced sickness behavior: Where do we stand? Brain Behav Immun 15, 7–24.PubMedCrossRefGoogle Scholar
  3. Ferrari, R. (1999). The role of TNF in cardiovascular disease. Pharmacol Res 40, 97–105.PubMedCrossRefGoogle Scholar
  4. Haack, M., Hinze-Selch, D., Fenzel, T., Kraus, T., Kühn, M., Schuld, A., and Pollmächer, T. (1999). Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: Effects of confounding factors and diagnosis. J Psychiatr Res 33, 407–418.PubMedCrossRefGoogle Scholar
  5. Hopkins, S.J., and Rothwell, N.J. (1995). Cytokines and the nervous system I: Expression and recognition. Trends Neurosci 18, 83–88.PubMedCrossRefGoogle Scholar
  6. Kluger, M.J. (1991). Fever: Role of pyrogens and cryogens. Physiol Rev 71, 93–127.PubMedGoogle Scholar
  7. Krueger, J.M., Obál, F., Jr., and Fang, J. (1999). Humoral regulation of physiological sleep: Cytokines and GHRH. J Sleep Res 8(Suppl 1), 53–59.PubMedCrossRefGoogle Scholar
  8. Mangge, H., Gallistl, S., and Schauenstein, K. (1999). Long-term follow-up of cytokines and soluble cytokine receptors in peripheral blood of patients with juvenile rheumatoid arthritis. J Interferon Cytokine Res 19, 1005–10.PubMedCrossRefGoogle Scholar
  9. Mullington, J., Korth, C., Herman, D.M., Orth, A., Galanos, C., Holsboer, F., and Pollmächer, T. (2000). Dose-dependent effects of endotoxin on human sleep. Am J Physiol Cell Physiol 278, R947-R955.Google Scholar
  10. Pollmächer, T., Haack, M., Schuld, A., Kraus, T., and Hinze-Selch, D. (2000). Effects of antipsychotic drugs on cytokine networks. J Psychiatr Res 34, 369–382.PubMedCrossRefGoogle Scholar
  11. Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., and Pollmächer, T. (2002). Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry 58, 445–452.CrossRefGoogle Scholar
  12. Rothwell, N.J., and Hopkins, S.J. (1995). Cytokines and the nervous system II: Actions and mechanisms of action. Trends Neurosci 18, 130–136.PubMedCrossRefGoogle Scholar
  13. Schuld, A., Haack, M., Hinze-Selch, D., Mullington, J., Pollmacher, T. (2005) Experimentelle Untersuchungen der Interaktion zwischen Schlaf und Immunsystem beim Menschen. Psychother Psychosom Med Psychol 55(1): 29–35.PubMedCrossRefGoogle Scholar
  14. Schuld, A., Haack, M., Hinze-Selch, D., Mullington J., and Pollmächer, T. (2001). Exoperimental studies on the interaction between sleep and the immune system in humans. Psychother Psych Med 55, 29–35.CrossRefGoogle Scholar
  15. Schuld, A., Mullington, J., Hermann, D., Hinze-Selch, D., Fenzel, T., Holsboer, F., and Pollmächer, T. (1999). Effects of granulocyte colony-stimulating factor on night sleep in humans. Am J Physiol 276, R1149-R1155.PubMedGoogle Scholar
  16. Smith, R.S. (1991). The macrophage theory of depression. Med Hypotheses 35, 298–306.PubMedCrossRefGoogle Scholar
  17. Turnbull, A.V., and Rivier, C.L. (1999). Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: Actions and mechanisms of action. Physiol Rev 79, 1–71.PubMedGoogle Scholar
  18. Yirmiya, R., Pollak, Y., Morag, M., Reichenberg, A., Barak, O., Avitsur, R., Shavit, Y., Ovadia, H., Weidenfeld, J., Morag, A., and Pollmächer, T. (2000). Illness, cytokines and depression. Ann N Y Acad Sci 917, 478–487.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2007

Authors and Affiliations

  • Andreas Schuld
  • Monika Haack
  • Janet Mullington
  • Thomas Pollmächer

There are no affiliations available

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