Genetic and Virological Predisposition to Pre-B Lymphomagenesis in SL/Kh

  • Hiroshi Hiai


Spontaneous pre-B lymphoma is a relatively infrequent hematopoietic malignancy in mice. Pre-B lymphomas are occasionally observed in some mouse models such as AKXD recombinant inbred (RI) strains, Eμ–myc transgenic mice, and Abelson virus-injected mice. In an inbred strain SL/Kh, pre-B lymphomas develop at an unusually high incidence (>90%) by 6 months of age [10]. Reintegration of the endogenous ecotropic murine leukemia virus (MuLV) provirus to host DNA is a pathogenetic mechanism [16, 36], but lymphoma development is largely dependent on a number of host loci as well as on epigenetic factors [8, 13]. Therefore, SL/Kh pre-B lymphoma is an excellent multifactorial disease model. In this article, we will review the origin of SL/Kh mice, the biological features of lymphomas in this strain, the virology and genetics of lymphomagenesis, the unusual transient expansion of pre-B cells in pre-cancerous bone marrow (BM), and provirus integration in lymphoma DNA leading to the...


Recombinant Inbred Recombinant Inbred Strain Quantitative Trait Locus Peak Lymphoma Development Backcross Mouse 
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List of Abbreviations


bone marrow


bone marrow pre-B-1


early lymphoma in SL/Kh-1


follicular center lymphoma-1




lymphoma latency acceleration


mink cell focus


major histocompatibility complex


mouse mammary tumor virus


maternal resistance factor


murine leukemia virus


phorbol myristic acetate


recombinant inbred


quantitative trait locus


SL/Kh virus integration-1


thymic lymphoma susceptible mouse-1



I am very grateful to all of my colleagues who have contributed to the understanding of pre-B lymphomagenesis in SL/Kh mice. This study was supported by grants-in-aid for Scientific Research by the Ministry of Education, Culture, Sports, and Science and Grants for Cancer Research by the Ministry of Health, Labor, and Welfare, Japan.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Hiroshi Hiai
    • 1
  1. 1.Shiga Medical Center Research Institute, 5-4-30 MoriyamaCity of MoriyamaJapan

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