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Genetic and Virological Predisposition to Pre-B Lymphomagenesis in SL/Kh

  • Hiroshi Hiai
Chapter

Introduction

Spontaneous pre-B lymphoma is a relatively infrequent hematopoietic malignancy in mice. Pre-B lymphomas are occasionally observed in some mouse models such as AKXD recombinant inbred (RI) strains, Eμ–myc transgenic mice, and Abelson virus-injected mice. In an inbred strain SL/Kh, pre-B lymphomas develop at an unusually high incidence (>90%) by 6 months of age [10]. Reintegration of the endogenous ecotropic murine leukemia virus (MuLV) provirus to host DNA is a pathogenetic mechanism [16, 36], but lymphoma development is largely dependent on a number of host loci as well as on epigenetic factors [8, 13]. Therefore, SL/Kh pre-B lymphoma is an excellent multifactorial disease model. In this article, we will review the origin of SL/Kh mice, the biological features of lymphomas in this strain, the virology and genetics of lymphomagenesis, the unusual transient expansion of pre-B cells in pre-cancerous bone marrow (BM), and provirus integration in lymphoma DNA leading to the...

Keywords

Recombinant Inbred Recombinant Inbred Strain Quantitative Trait Locus Peak Lymphoma Development Backcross Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations

BM

bone marrow

Bomb-1

bone marrow pre-B-1

Esl-1

early lymphoma in SL/Kh-1

Foc-1

follicular center lymphoma-1

Ig

immunoglobulin

Lla

lymphoma latency acceleration

MCF

mink cell focus

MHC

major histocompatibility complex

MMMTV

mouse mammary tumor virus

MRF

maternal resistance factor

MuLV

murine leukemia virus

PMA

phorbol myristic acetate

RI

recombinant inbred

QTL

quantitative trait locus

Svi-1

SL/Kh virus integration-1

Tlsm-1

thymic lymphoma susceptible mouse-1

Notes

Acknowledgments

I am very grateful to all of my colleagues who have contributed to the understanding of pre-B lymphomagenesis in SL/Kh mice. This study was supported by grants-in-aid for Scientific Research by the Ministry of Education, Culture, Sports, and Science and Grants for Cancer Research by the Ministry of Health, Labor, and Welfare, Japan.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Hiroshi Hiai
    • 1
  1. 1.Shiga Medical Center Research Institute, 5-4-30 MoriyamaCity of MoriyamaJapan

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