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Mouse Models of Human Mature B-Cell and Plasma Cell Neoplasms

  • Siegfried Janz
  • Herbert C. MorseIII
  • Michael A. Teitell
Chapter

Introduction

Developing mouse models that accurately reflect features of human B-cell lineage neoplasms has been a daunting but increasingly rewarding task. Studies of spontaneous tumors or those induced by chemicals, irradiation, or retroviruses performed before the 1980s provided remarkable insights into mechanisms and genetics of lymphomagenesis. With the advent of genetic engineering, it became possible to rapidly develop and explore new models and to enhance the value of established systems. Here, we will review past and present accomplishments in modeling mature human B-cell lymphomas and plasmas cell neoplasms (PCN) in mice, examine their strengths and limitations, and discuss obstacles that must be addressed in future work. These systems have accelerated our ability to understand the development of complex disease in vivo and to develop novel therapeutic approaches to diseases, many of which are almost uniformly lethal.

The cellular origins of human mature B cell and PCN...

Keywords

Multiple Myeloma Chronic Lymphocytic Leukemia Histiocytic Sarcoma Splenic Marginal Zone Lymphoma Genetically Engineer Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Siegfried Janz
    • 1
  • Herbert C. MorseIII
  • Michael A. Teitell
  1. 1.Department of Pathology, Carver College of MedicineUniversity of IowaIowa CityUSA

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