Dietary Restriction: A Model System Probing the Cell Fate Decision Between Cancer and Senescence
A major aspect of cancer is unregulated cell proliferation. Yet, in general as organisms age, their cells lose the ability to proliferate, which leads to cellular senescence (Hayflick 1965; Smith and Pereira-Smith 1996). It is important to remember that the ability of stem cells to repopulate a tissue in vivo requires more than just proliferation. It requires a coordinated pattern of homing, engraftment, self-renewal, differentiation, and proliferation. In this chapter, all of these necessary functions are referred to collectively as repopulating ability (RA). The loss of RA can cause severe clinical problems with age, such as anemia (Robinson 2003; Guralnik et al. 2004; Penninx et al. 2004). There are treatments that can increase RA and delay senescence. Unfortunately, most of these treatments also increase the risk of cancer (Campisi 2003; Pardal et al. 2005; Beausejour and Campisi 2006). The maximal potential lifespan of an organism, therefore, seems to depend on...
KeywordsDiet Restriction Cellular Senescence Flow Criterion Cell Fate Decision Serial Transplantation
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