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Mechanisms of DNA Double-Strand Break Repair in Hematopoietic Homeostasis and Oncogenesis

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Abbreviations

AID:

Activation-induced cytidine deaminase

ALL:

Acute lymphoblastic leukemia

AML:

Acute myeloid leukemia

ART:

Artemis

AT:

Ataxia telangiectasia

ATM:

Ataxia telangiectasia mutated

ATR:

ATM and Rad3 related

B-ALL:

B-cell acute lymphoblastic leukemia

BFB:

Breakage–fusion–bridge

CHO:

Chinese hamster ovary

CML:

Chronic myelogenous leukemia

CSR:

Class switch recombination

DNA–PKcs:

DNA-dependent protein kinase catalytic subunit

DSB:

DNA double-strand break

FA:

Fanconi anemia

GC:

Gene conversion

H2AX:

Histone H2A variant X

HR:

Homologous recombination

ICL:

Interstrand crosslinking

Ig:

Immunoglobulin

IgH:

Immunoglobulin heavy chain

IR:

Ionizing radiation

Lig4:

Ligase IV

MDS:

Myelodysplastic syndrome

MEF:

Mouse embryonic fibroblast

MMC:

Mitomycin-C

MRN:

Mre11-Rad50-Nbs1 complex

NHEJ:

Nonhomologous end joining

Ph:

Philadelphia

Pre-T LBL:

Pre-T cell lymphoblastic leukemia

RAG:

Recombination-activating gene

RPA:

Replication protein A

RS:

Recombination signal sequences

RS-SCID:

Radiation-sensitive SCID

SCE:

Sister chromatid exchange

SCID:

Severe combined immunodeficiency

SDSA:

Synthesis-dependent strand annealing

SHM:

Somatic hypermutation

SSA:

Single-strand annealing

ssDNA:

Single-stranded DNA

T-ALL:

T-cell acute lymphoblastic leukemia or lymphoma

TCR:

T-cell receptor

TOPOIII:

Topoisomerase III

XLF:

XRCC4-like factor

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Acknowledgments

We thank Dr. Sophie La Salle for critical review of this manuscript.

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  1. The Jackson Laboratory, Bar Harbor, ME 04609, USA

    Sarah A. Maas

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  1. Sarah A. Maas
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  2. Lura Brianna Caddle
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    Maas, S.A., Caddle, L.B., Mills, K.D. (2008). Mechanisms of DNA Double-Strand Break Repair in Hematopoietic Homeostasis and Oncogenesis. In: Li, S. (eds) Mouse Models of Human Blood Cancers. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69132-9_4

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