Genetic Modeling of Human Blood Cancers in Mice

  • Yiguo Hu
  • Shaoguang Li


Leukemia is a broad term describing a spectrum of diseases involving white blood cells and is divided into four categories: acute or chronic myelogenous and acute or chronic lymphocytic leukemia (CLL). Acute leukemia is characterized by the rapid proliferation of immature blood cells that cannot carry out their normal functions. Acute leukemia generally occurs in children and young adults and needs immediate treatment because of the rapid progression and accumulation of the malignant cells in the body. Chronic leukemia is distinguished by the excessive and slow build-up of relatively mature white blood cells, which can still carry out some of their normal functions. Chronic leukemia mostly occurs in older people but can theoretically occur in any age group. Whereas acute leukemia must be treated immediately, chronic forms are sometimes monitored for some time before treatment to ensure maximum effectiveness of therapy. Classification of leukemia into myeloid or lymphoid...


Acute Myeloid Leukemia Chronic Lymphocytic Leukemia Chronic Myeloid Leukemia Acute Promyelocytic Leukemia Internal Tandem Duplication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Yiguo Hu
  • Shaoguang Li
    • 1
  1. 1.The Jackson LaboratoryBar HarborUSA

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