Mouse Models of Myeloproliferative Disease Associated with Mutant JAK2 Tyrosine Kinase: Insights into Pathophysiology and Therapy

  • Richard A. Van Etten

Dysregulated Tyrosine Kinases are the Hallmark of Chronic Myeloproliferative-Like Syndromes

The classical myeloproliferative diseases (MPDs) include chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF, also known as myelofibrosis with myeloid metaplasia or agnogenic myeloid metaplasia). These diseases were first grouped together by Dr. William Dameshek of Tufts-New England Medical Center in a seminal paper in Blood in 1951 (Dameshek 1951). The MPDs are clonal disorders of hematopoiesis characterized by overproduction of mature myeloerythroid cells, abnormalities of hemostasis and thrombosis, and tendency to progress to acute leukemia (Van Etten and Shannon 2004). In the 2001 WHO classification, chronic eosinophilic leukemia (CEL) was included among the MPDs while a closely related group of diseases with mixed myelodysplastic/myeloproliferative features was also recognized (Vardiman et al. 2002). Over the last several...


Chronic Myeloid Leukemia Polycythemia Vera Essential Thrombocythemia Erythroid Progenitor Chronic Myeloid Leukemia Cell 
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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Richard A. Van Etten
    • 1
  1. 1.Molecular Oncology Research Institute and Division of Hematology/OncologyTufts Medical CenterBostonUSA

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