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Role of Reactive Oxygen Species in T-Cell Defects in Cancer

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Tumor-Induced Immune Suppression

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References

  • Agostinelli, E., and Seiler, N. (2006). Non-irradiation-derived reactive oxygen species (ROS) and cancer: therapeutic implications. Amino Acids 31:341–355.

    PubMed  CAS  Google Scholar 

  • Almand, B., Clark, J. I., Nikitina, E., English, N. R., Knight, S. C., Carbone, D. P., and Gabrilovich, D. I. (2001). Increased production of immature myeloid cells in cancer patients. A mechanism of immunosuppression in cancer. J Immunol 166:678–689.

    PubMed  CAS  Google Scholar 

  • Alvarez, B., and Radi, R. (2003). Peroxynitrite reactivity with amino acids and proteins. Amino Acids 25:295–311.

    PubMed  CAS  Google Scholar 

  • Amici, M., Lupidi, G., Angeletti, M., Fioretti, E., and Eleuteri, A. M. (2003). Peroxynitrite-induced oxidation and its effects on isolated proteasomal systems. Free Radic Biol Med 34:987–996.

    PubMed  CAS  Google Scholar 

  • Andreyev, A. Y., Kushnareva, Y. E., and Starkov, A. A. (2005). Mitochondrial metabolism of reactive oxygen species. Biochemistry (Mosc) 70:200–214.

    CAS  Google Scholar 

  • Aoe, T., Okamoto, Y., and Saito, T. (1995). Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex. J Exp Med 181:1881–1886.

    PubMed  CAS  Google Scholar 

  • Assari, T. (2006). Chronic granulomatous disease; fundamental stages in our understanding of CGD. Med Immunol 5:4.

    Google Scholar 

  • Babior, B. M. (1984). The respiratory burst of phagocytes. J Clin Invest 73:599–601.

    PubMed  CAS  Google Scholar 

  • Bagley, J., Singh, G., and Iacomini, J. (2007). Regulation of oxidative stress responses by ataxia-telangiectasia mutated is required for T cell proliferation. J Immunol 178:4757–4763.

    PubMed  CAS  Google Scholar 

  • Banfi, B., Clark, R. A., Steger, K., and Krause, K. H. (2003). Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem 278:3510–3513.

    PubMed  CAS  Google Scholar 

  • Banfi, B., Malgrange, B., Knisz, J., Steger, K., Dubois-Dauphin, M., and Krause, K. H. (2004). NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem 279: 46065–46072.

    PubMed  CAS  Google Scholar 

  • Bentz, B. G., Haines, G. K., 3rd and Radosevich, J. A. (2000). Increased protein nitrosylation in head and neck squamous cell carcinogenesis. Head Neck 22:64–70.

    PubMed  CAS  Google Scholar 

  • Bingisser, R. M., Tilbrook, P. A., Holt, P. G., and Kees, U. R. (1998). Macrophage-derived nitric oxide regulates T cell activation via reversible disruption of the Jak3/STAT5 signaling pathway. J Immunol 160:5729–5734.

    PubMed  CAS  Google Scholar 

  • Bolis, A., Corbetta, S., Cioce, A., and de Curtis, I. (2003). Differential distribution of Rac1 and Rac3 GTPases in the developing mouse brain: implications for a role of Rac3 in Purkinje cell differentiation. Eur J Neurosci 18:2417–2424.

    PubMed  Google Scholar 

  • Bonnefoy, M., Drai, J., and Kostka, T. (2002). [Antioxidants to slow aging, facts and perspectives]. Presse Med 31:1174–1184.

    PubMed  Google Scholar 

  • Boucher, J. L., Moali, C., and Tenu, J. P. (1999). Nitric oxide biosynthesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization. Cell Mol Life Sci 55:1015–1028.

    PubMed  CAS  Google Scholar 

  • Boutard, V., Havouis, R., Fouqueray, B., Philippe, C., Moulinoux, J. P., and Baud, L. (1995). Transforming factor beta stimulates arginase activity in macrophages: implications for the regulation of macrophage cytotoxicity. J Immunol 155:2077–2084.

    PubMed  CAS  Google Scholar 

  • Bronte, V., Casic, T., Gri, G., Gallana, K., Borsellino, G., Marrigo, I., Battistini, L., Iafrate, M., Prayer-Galletti, U., Pagano, F., and Viola, A. (2005). Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers. J Exp Med 201:1257–1268.

    PubMed  CAS  Google Scholar 

  • Bronte, V., Serafini, P., De Santo, C., Marigo, I., Tosello, V., Mazzoni, A., Segal, D. M., Staib, C., Lowel, M., Sutter, G., Colombo, M. P., and Zanovello, P. (2003). IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice. J Immunol 170:270–278.

    PubMed  CAS  Google Scholar 

  • Bronte, V., Wang, M., Overwijk, W., Surman, D., Pericle, F., Rosenberg, S. A., and Restifo, N. P. (1998). Apoptotic death of CD8+ T lymphocytes after immunization: induction of a suppressive population of Mac-1+/Gr-1+ cells. J Immunol 161:5313–5320.

    PubMed  CAS  Google Scholar 

  • Cawthon, A. G., and Alexander-Miller, M. A. (2002). Optimal colocalization of TCR and CD8 as a novel mechanism for the control of functional avidity. J Immunol 169:3492–3498.

    PubMed  CAS  Google Scholar 

  • Chen, J. J., and Yu, B. P. (1994). Alterations in mitochondrial membrane fluidity by lipid peroxidation products. Free Radic Biol Med 17:411–418.

    PubMed  CAS  Google Scholar 

  • Chiarugi, P., Pani, G., Giannoni, E., Taddei, L., Colavitti, R., Raugei, G., Symons, M., Borrello, S., Galeotti, T., and Ramponi, G. (2003). Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion. J Cell Biol 161:933–944.

    PubMed  CAS  Google Scholar 

  • Chio, K. S., and Tappel, A. L. (1969). Synthesis and characterization of the fluorescent products derived from malonaldehyde and amino acids. Biochemistry 8:2821–2826.

    PubMed  CAS  Google Scholar 

  • Cobbs, C. S., Whisenhunt, T. R., Wesemann, D. R., Harkins, L. E., Van Meir, E. G., Samanta, M. (2003). Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells. Cancer Res 63:8670–8673.

    PubMed  CAS  Google Scholar 

  • Dairou, J., Dupret, J. M., and Rodrigues-Lima, F. (2005). Impairment of the activity of the xenobiotic-metabolizing enzymes arylamine N-acetyltransferases 1 and 2 (NAT1/NAT2) by peroxynitrite in mouse skeletal muscle cells. FEBS Lett 579:4719–4723.

    PubMed  CAS  Google Scholar 

  • Datta, D., Vaidehi, N., Xu, X., and Goddard, W. A., 3rd (2002). Mechanism for antibody catalysis of the oxidation of water by singlet dioxygen. Proc Natl Acad Sci U S A 99:2636–2641.

    PubMed  CAS  Google Scholar 

  • Dean, R. T., Fu, S., Stocker, R., and Davies, M. J. (1997). Biochemistry and pathology of radical-mediated protein oxidation. Biochem J 324 (Pt 1):1–18.

    PubMed  CAS  Google Scholar 

  • Decoursey, T. E., and Ligeti, E. (2005). Regulation and termination of NADPH oxidase activity. Cell Mol Life Sci 62:2173–2193.

    PubMed  CAS  Google Scholar 

  • Denu, J. M., and Tanner, K. G. (1998). Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation. Biochemistry 37:5633–5642.

    PubMed  CAS  Google Scholar 

  • Drake, D. R., 3rd, Ream, R. M., Lawrence, C. W., and Braciale, T. J. (2005). Transient loss of MHC class I tetramer binding after CD8+ T cell activation reflects altered T cell effector function. J Immunol 175:1507–1515.

    PubMed  CAS  Google Scholar 

  • Edgeworth, J., Gorman, M., Bennett, R., Freemont, P., and Hogg, N. (1991). Identification of p8,14 as a highly abundant heterodimeric calcium binding protein complex of myeloid cells. J Biol Chem 266:7706–7713.

    PubMed  CAS  Google Scholar 

  • Ekmekcioglu, S., Ellerhorst, J., Smid, C. M., Prieto, V. G., Munsell, M., Buzaid, A. C., and Grimm, E. A. (2000). Inducible nitric oxide synthase and nitrotyrosine in human metastatic melanoma tumors correlate with poor survival. Clin Cancer Res 6:4768–4775.

    PubMed  CAS  Google Scholar 

  • Eze, M. O. (1992). Membrane fluidity, reactive oxygen species, and cell-mediated immunity: implications in nutrition and disease. Med Hypotheses 37:220–224.

    PubMed  CAS  Google Scholar 

  • Fahmy, T. M., Bieler, J. G., Edidin, M., and Schneck, J. P. (2001). Increased TCR avidity after T cell activation: a mechanism for sensing low-density antigen. Immunity 14:135–143.

    PubMed  CAS  Google Scholar 

  • Ferraro, D., Corso, S., Fasano, E., Panieri, E., Santangelo, R., Borrello, S., Giordano, S., Pani, G., and Galeotti, T. (2006). Pro-metastatic signaling by c-Met through RAC-1 and reactive oxygen species (ROS). Oncogene 25:3689–3698.

    PubMed  CAS  Google Scholar 

  • Finan, P., Shimizu, Y., Gout, I., Hsuan, J., Truong, O., Butcher, C., Bennett, P., Waterfield, M. D., and Kellie, S. (1994). An SH3 domain and proline-rich sequence mediate an interaction between two components of the phagocyte NADPH oxidase complex. J Biol Chem 269:13752–13755.

    PubMed  CAS  Google Scholar 

  • Forman, H. J., and Torres, M. (2002). Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling. Am J Respir Crit Care Med 166:S4–S8.

    Google Scholar 

  • Francke, U., Hsieh, C. L., Foellmer, B. E., Lomax, K. J., Malech, H. L., and Leto, T. L. (1990). Genes for two autosomal recessive forms of chronic granulomatous disease assigned to 1q25 (NCF2) and 7q11.23 (NCF1). Am J Hum Genet 47:483–492.

    PubMed  CAS  Google Scholar 

  • Fu, X., Kassim, S. Y., Parks, W. C., and Heinecke, J. W. (2003). Hypochlorous acid generated by myeloperoxidase modifies adjacent tryptophan and glycine residues in the catalytic domain of matrix metalloproteinase-7 (matrilysin): an oxidative mechanism for restraining proteolytic activity during inflammation. J Biol Chem 278:28403–28409.

    PubMed  CAS  Google Scholar 

  • Fu, Y., Watson, G., Jimenez, J., Wang, Y., and Lopez, D. (1990). Expansion of immunoregulatory macrophages by granulocyte-macrophage colony-stimulating factor derived from a murine mammary tumor.Cancer Res 50:227.

    PubMed  CAS  Google Scholar 

  • Gabrilovich, D. (2004). Mechanisms and functional significance of tumour-induced dendritic-cell defects. Nat Rev Immunol 4:941–952.

    PubMed  CAS  Google Scholar 

  • Gabrilovich, D., Bronte, V., Chen, S.-H., Colombo, M. P., Ochoa, A., Ostrand-Rosenberg, S., and Schreiber, H. (2007). The terminology issue for myeloid-derived suppressor cells. Cancer Res 67:425.

    Google Scholar 

  • Gabrilovich, D. I., Velders, M., Sotomayor, E., and Kast, W. M. (2001). Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cells. J Immunol 166:5398–5406.

    PubMed  CAS  Google Scholar 

  • Gebhardt, C., Nemeth, J., Angel, P., and Hess, J. (2006). S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol 72:1622–1631.

    PubMed  CAS  Google Scholar 

  • Geiszt, M., Lekstrom, K., Witta, J., and Leto, T. L. (2003). Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. J Biol Chem 278:20006–20012.

    PubMed  CAS  Google Scholar 

  • Gotoh, Y., and Cooper, J. A. (1998). Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-alpha signal transduction. J Biol Chem 273:17477–17482.

    PubMed  CAS  Google Scholar 

  • Groemping, Y., and Rittinger, K. (2005). Activation and assembly of the NADPH oxidase: a structural perspective. Biochem J 386:401–416.

    PubMed  CAS  Google Scholar 

  • Groves, J. T. (1999). Peroxynitrite: reactive, invasive and enigmatic. Curr Opin Chem Biol 3:226–235.

    PubMed  CAS  Google Scholar 

  • Grune, T., Reinheckel, T., and Davies, K. J. (1997). Degradation of oxidized proteins in mammalian cells. FASEB J 11:526–534.

    PubMed  CAS  Google Scholar 

  • Haataja, L., Groffen, J., and Heisterkamp, N. (1997). Characterization of RAC3, a novel member of the Rho family. J Biol Chem 272:20384–20388.

    PubMed  CAS  Google Scholar 

  • Hampton, M. B., Kettle, A. J., and Winterbourn, C. C. (1998). Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing. Blood 92:3007–3017.

    PubMed  CAS  Google Scholar 

  • Han, C. H., Freeman, J. L., Lee, T., Motalebi, S. A., and Lambeth, J. D. (1998). Regulation of the neutrophil respiratory burst oxidase. Identification of an activation domain in p67(phox). J Biol Chem 273:16663–16668.

    PubMed  CAS  Google Scholar 

  • Han, C. H., and Lee, M. H. (2000). Activation domain in P67phox regulates the steady state reduction of FAD in gp91phox. J Vet Sci 1:27–31.

    PubMed  CAS  Google Scholar 

  • Harari, O., and Liao, J. K. (2004). Inhibition of MHC II gene transcription by nitric oxide and antioxidants. Curr Pharm Des 10:893–898.

    PubMed  CAS  Google Scholar 

  • Huang, B., Pan, P. Y., Li, Q., Sato, A. I., Levy, D. E., Bromberg, J., Divino, C. M., and Chen, S. H. (2006). Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res 66:1123–1131.

    PubMed  CAS  Google Scholar 

  • Husemann, J., Obstfeld, A., Febbraio, M., Kodama, T., and Silverstein, S. C. (2001). CD11b/CD18 mediates production of reactive oxygen species by mouse and human macrophages adherent to matrixes containing oxidized LDL. Arterioscler Thromb Vasc Biol 21:1301–1305.

    PubMed  CAS  Google Scholar 

  • Kamata, H., Manabe, T., Oka, S., Kamata, K., and Hirata, H. (2002). Hydrogen peroxide activates IkappaB kinases through phosphorylation of serine residues in the activation loops. FEBS Lett 519:231–237.

    PubMed  CAS  Google Scholar 

  • Kao, C., Daniels, M. A., and Jameson, S. C. (2005). Loss of CD8 and TCR binding to Class I MHC ligands following T cell activation. Int Immunol 17:1607–1617.

    PubMed  CAS  Google Scholar 

  • Kerkhoff, C., Klempt, M., and Sorg, C. (1998). Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). Biochim Biophys Acta 1448:200–211.

    PubMed  CAS  Google Scholar 

  • Kinnula, V. L., Torkkeli, T., Kristo, P., Sormunen, R., Soini, Y., Paakko, P., Ollikainen, T., Kahlos, K., Hirvonen, A., and Knuutila, S. (2004). Ultrastructural and chromosomal studies on manganese superoxide dismutase in malignant mesothelioma. Am J Respir Cell Mol Biol 31: 147–153.

    PubMed  CAS  Google Scholar 

  • Kono, K., Salazar-Onfray, F., Petersson, M., Hansson, J., Masucci, G., Wasserman, K., Nakazawa, T., Anderson, P., and Kiessling, R. (1996). Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing zeta molecules and inhibits tumor-specific T cell-and natural killer cell-mediated cytotoxicity. Eur J Immunol 26:1308–1313.

    PubMed  CAS  Google Scholar 

  • Kusmartsev, S., and Gabrilovich, D. I. (2003). Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species. J Leukoc Biol 74:186-196.

    Google Scholar 

  • Kusmartsev, S., and Gabrilovich, D. (2005). STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion. J Immunol 174:4880–4891.

    PubMed  CAS  Google Scholar 

  • Kusmartsev, S., and Gabrilovich, D. I. (2006). Role of immature myeloid cells in mechanisms of immune evasion in cancer. Cancer Immunol Immunother 55:237–245.

    PubMed  Google Scholar 

  • Kusmartsev, S., Li, Y., and Chen, S. (2000). Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation. J Immunol 165:779.

    Google Scholar 

  • Kusmartsev, S., Nagaraj, S., and Gabrilovich, D. I. (2005). Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cells. J Immunol 175:4583–4592.

    PubMed  CAS  Google Scholar 

  • Kusmartsev, S., Nefedova, Y., Yoder, D., and Gabrilovich, D. I. (2004). Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species. J Immunol 172:989–999.

    PubMed  CAS  Google Scholar 

  • Kyaw, M., Yoshizumi, M., Tsuchiya, K., Kirima, K., Suzaki, Y., Abe, S., Hasegawa, T., and Tamaki, T. (2002). Antioxidants inhibit endothelin-1 (1-31)-induced proliferation of vascular smooth muscle cells via the inhibition of mitogen-activated protein (MAP) kinase and activator protein-1 (AP-1). Biochem Pharmacol 64:1521–1531.

    PubMed  CAS  Google Scholar 

  • Laurent, A., Nicco, C., Chereau, C., Goulvestre, C., Alexandre, J., Alves, A., Levy, E., Goldwasser, F., Panis, Y., Soubrane, O., Weill, B., and Batteux, F. (2005). Controlling tumor growth by modulating endogenous production of reactive oxygen species. Cancer Res 65: 948–956.

    PubMed  CAS  Google Scholar 

  • Leonard, S. S., Harris, G. K., and Shi, X. (2004). Metal-induced oxidative stress and signal transduction. Free Radic Biol Med 37:1921–1942.

    PubMed  CAS  Google Scholar 

  • Leto, T. L., Adams, A. G., and de Mendez, I. (1994). Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets. Proc Natl Acad Sci U S A 91:10650–10654.

    PubMed  CAS  Google Scholar 

  • Li, Q., Pan, P. Y., Gu, P., Xu, D., and Chen, S. H. (2004). Role of immature myeloid Gr-1+ cells in the development of antitumor immunity. Cancer Res 64:1130–1139.

    PubMed  CAS  Google Scholar 

  • Lockhart, D. C., Chan, A. K., Mak, S., Joo, H. G., Daust, H. A., Carritte, A., Douville, C. C., Goedegebuure, P. S., and Eberlein, T. J. (2001). Loss of T-cell receptor-CD3zeta and T-cell function in tumor-infiltrating lymphocytes but not in tumor-associated lymphocytes in ovarian carcinoma. Surgery 129:749–756.

    PubMed  CAS  Google Scholar 

  • Maile, R., Siler, C. A., Kerry, S. E., Midkiff, K. E., Collins, E. J., and Frelinger, J. A. (2005). Peripheral “CD8 tuning” dynamically modulates the size and responsiveness of an antigen-specific T cell pool in vivo. J Immunol 174:619–627.

    PubMed  CAS  Google Scholar 

  • Malmberg, K. J., Arulampalam, V., Ichihara, F., Petersson, M., Seki, K., Andersson, T., Lenkei, R., Masucci, G., Pettersson, S., and Kiessling, R. (2001). Inhibition of activated/memory (CD45RO(+)) T cells by oxidative stress associated with block of NF-kappaB activation. J Immunol 167:2595–2601.

    PubMed  CAS  Google Scholar 

  • Mantovani, G., Maccio, A., Madeddu, C., Mura, L., Gramignano, G., Lusso, M. R., Massa, E., Mocci, M., and Serpe, R. (2003). Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stress. J Mol Med 81:664–673.

    PubMed  CAS  Google Scholar 

  • Marnett, L. J., Hurd, H. K., Hollstein, M. C., Levin, D. E., Esterbauer, H., and Ames, B. N. (1985). Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA104. Mutat Res 148:25–34.

    PubMed  CAS  Google Scholar 

  • Mates, J. M., Perez-Gomez, C., and Nunez de Castro, I. (1999). Antioxidant enzymes and human diseases. Clin Biochem 32:595–603.

    PubMed  CAS  Google Scholar 

  • Melani, C., Chiodoni, C., Forni, G., and Colombo, M. P. (2003). Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity. Blood 102:2138–2145.

    PubMed  CAS  Google Scholar 

  • Modolell, M., Corraliza, I. M., Link, F., Soler, G., and Eichmann, K. (1995). Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow derived macrophages by Th1 and Th2 cytokines. Eur J Immunol 25:1101–1104.

    PubMed  CAS  Google Scholar 

  • Moll, J., Sansig, G., Fattori, E., and van der Putten, H. (1991). The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments. Oncogene 6:863–866.

    PubMed  CAS  Google Scholar 

  • Mustelin, T., Vang, T., and Bottini, N. (2005). Protein tyrosine phosphatases and the immune response. Nat Rev Immunol 5:43–57.

    PubMed  CAS  Google Scholar 

  • Nagaraj, S., Gupta, K., Pisarev, V., Kinarsky, L., Sherman, S., Kang, L., Herber, D., Schneck, J., and Gabrilovich, D. (2007). Altered recognition of antigen is a novel mechanism of CD8+ T cell tolerance in cancer. Nat Med 13:828–835.

    PubMed  CAS  Google Scholar 

  • Nakamura, Y., Yasuoka, H., Tsujimoto, M., Yoshidome, K., Nakahara, M., Nakao, K., Nakamura, M., and Kakudo, K. (2006). Nitric oxide in breast cancer: induction of vascular endothelial growth factor-C and correlation with metastasis and poor prognosis. Clin Cancer Res 12:1201–1207.

    PubMed  CAS  Google Scholar 

  • Nefedova, Y., Huang, M., Kusmartsev, S., Bhattacharya, R., Cheng, P., Salup, R., Jove, R., and Gabrilovich, D. (2004). Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer. J Immunol 172:464–474.

    PubMed  CAS  Google Scholar 

  • Newton, R. A., and Hogg, N. (1998). The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophils. J Immunol 160:1427–1435.

    PubMed  CAS  Google Scholar 

  • Nicholls, S. J., and Hazen, S. L. (2005). Myeloperoxidase and cardiovascular disease. Arterioscler Thromb Vasc Biol 25:1102–1111.

    PubMed  CAS  Google Scholar 

  • Okada, F., Kobayashi, M., Tanaka, H., Kobayashi, T., Tazawa, H., Iuchi, Y., Onuma, K., Hosokawa, M., Dinauer, M. C., and Hunt, N. H. (2006). The role of nicotinamide adenine dinucleotide phosphate oxidase-derived reactive oxygen species in the acquisition of metastatic ability of tumor cells. Am J Pathol 169:294–302.

    PubMed  CAS  Google Scholar 

  • Otsuji, M., Kimura, Y., Aoe, T., Okamoto, Y., and Saito, T. (1996). Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 zeta chain of T-cell receptor complex and antigen-specific T-cell responses. Proc Natl Acad Sci USA 93:13119–13124.

    PubMed  CAS  Google Scholar 

  • Pastore, A., Federici, G., Bertini, E., and Piemonte, F. (2003). Analysis of glutathione: implication in redox and detoxification. Clin Chim Acta 333:19–39.

    PubMed  CAS  Google Scholar 

  • Rabinovich, G. A., Gabrilovich, D., and Sotomayor, E. M. (2007). Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol 25:267–296.

    PubMed  CAS  Google Scholar 

  • Reeves, E. P., Lu, H., Jacobs, H. L., Messina, C. G., Bolsover, S., Gabella, G., Potma, E. O., Warley, A., Roes, J., and Segal, A. W. (2002). Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature 416:291–297.

    PubMed  CAS  Google Scholar 

  • Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., and Hall, A. (1992). The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401–410.

    PubMed  CAS  Google Scholar 

  • Rivoltini, L., Carrabba, M., Huber, V., Castelli, C., Novellino, L., Dalerba, P., Mortarini, R., Arancia, G., Anichini, A., Fais, S., and Parmiani, G. (2002). Immunity to cancer: attack and escape in T lymphocyte-tumor cell interaction. Immunol Rev 188:97–113.

    PubMed  CAS  Google Scholar 

  • Rodaway, A. R., Teahan, C. G., Casimir, C. M., Segal, A. W., and Bentley, D. L. (1990). Characterization of the 47-kilodalton autosomal chronic granulomatous disease protein: tissue-specific expression and transcriptional control by retinoic acid. Mol Cell Biol 10:5388–5396.

    PubMed  CAS  Google Scholar 

  • Rodriguez, A. M., Carrico, P. M., Mazurkiewicz, J. E., and Melendez, J. A. (2000). Mitochondrial or cytosolic catalase reverses the MnSOD-dependent inhibition of proliferation by enhancing respiratory chain activity, net ATP production, and decreasing the steady state levels of H(2)O(2). Free Radic Biol Med 29:801–813.

    PubMed  CAS  Google Scholar 

  • Ruiz de Morales, J., Velez, D., and Subiza, J. (1999). Ehrlich tumor stimulates extramedullar hematopoiesis in mice without secreting identifiable colony-stimulating factors and without engagement of host T cells. Exp Hematol 27:1757.

    PubMed  CAS  Google Scholar 

  • Ryter, S. W., and Tyrrell, R. M. (1998). Singlet molecular oxygen ((1)O2): a possible effector of eukaryotic gene expression. Free Radic Biol Med 24:1520–1534.

    PubMed  CAS  Google Scholar 

  • Salvadori, S., Martinelli, G., and Zier, K. (2000). Resection of solid tumors reverses T cell defects and restores protective immunity. J Immunol 164:2214.

    PubMed  CAS  Google Scholar 

  • Sathyamoorthy, M., de Mendez, I., Adams, A. G., and Leto, T. L. (1997). p40(phox) down-regulates NADPH oxidase activity through interactions with its SH3 domain. J Biol Chem 272:9141–9146.

    PubMed  CAS  Google Scholar 

  • Sauer, H., Wartenberg, M., and Hescheler, J. (2001). Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell Physiol Biochem 11:173–186.

    PubMed  CAS  Google Scholar 

  • Schmielau, J., and Finn, O. J. (2001). Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients. Cancer Res 61:4756–4760.

    PubMed  CAS  Google Scholar 

  • Segal, A. W. (2005). How neutrophils kill microbes. Annu Rev Immunol 23:197–223.

    PubMed  CAS  Google Scholar 

  • Serafini, P., Borrello, I., and Bronte, V. (2006). Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression. Semin Cancer Biol 16:53–65.

    PubMed  CAS  Google Scholar 

  • Stadtman, E. R., and Oliver, C. N. (1991). Metal-catalyzed oxidation of proteins. Physiological consequences. J Biol Chem 266:2005–2008.

    PubMed  CAS  Google Scholar 

  • Starke-Reed, P. E., and Oliver, C. N. (1989). Protein oxidation and proteolysis during aging and oxidative stress. Arch Biochem Biophys 275:559–567.

    PubMed  CAS  Google Scholar 

  • St Clair, D., Zhao, Y., Chaiswing, L., and Oberley, T. (2005). Modulation of skin tumorigenesis by SOD. Biomed Pharmacother 59:209–214.

    PubMed  CAS  Google Scholar 

  • Szuster-Ciesielska, A., Hryciuk-Umer, E., Stepulak, A., Kupisz, K., and Kandefer-Szerszen, M. (2004). Reactive oxygen species production by blood neutrophils of patients with laryngeal carcinoma and antioxidative enzyme activity in their blood. Acta Oncol 43:252–258.

    PubMed  CAS  Google Scholar 

  • Szweda, L. I., Uchida, K., Tsai, L., and Stadtman, E. R. (1993). Inactivation of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Selective modification of an active-site lysine. J Biol Chem 268:3342–3347.

    PubMed  CAS  Google Scholar 

  • Takada, Y., Mukhopadhyay, A., Kundu, G. C., Mahabeleshwar, G. H., Singh, S., and Aggarwal, B. B. (2003). Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase. J Biol Chem 278:24233–24241.

    PubMed  CAS  Google Scholar 

  • Terabe, M., Matsui, S., Park, J. M., Mamura, M., Noben-Trauth, N., Donaldson, D. D., Chen, W., Wahl, S. M., Ledbetter, S., Pratt, B., Letterio, J. J., Paul, W. E., and Berzofsky, J. A. (2003). Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: abrogation prevents tumor recurrence. J Exp Med 198:1741–1752.

    PubMed  CAS  Google Scholar 

  • Tobiume, K., Saitoh, M., and Ichijo, H. (2002). Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer. J Cell Physiol 191:95–104.

    PubMed  CAS  Google Scholar 

  • Valko, M., Izakovic, M., Mazur, M., Rhodes, C. J., and Telser, J. (2004). Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem 266:37–56.

    PubMed  CAS  Google Scholar 

  • Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., and Mazur, M. (2006). Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160:1–40.

    PubMed  CAS  Google Scholar 

  • Vickers, S. M., MacMillan-Crow, L. A., Green, M., Ellis, C., and Thompson, J. A. (1999). Association of increased immunostaining for inducible nitric oxide synthase and nitrotyrosine with fibroblast growth factor transformation in pancreatic cancer. Arch Surg 134:245–251.

    PubMed  CAS  Google Scholar 

  • Waris, G., and Ahsan, H. (2006). Reactive oxygen species: role in the development of cancer and various chronic conditions. J Carcinog 5:14.

    PubMed  Google Scholar 

  • Weiss, S. J., Test, S. T., Eckmann, C. M., Roos, D., and Regiani, S. (1986). Brominating oxidants generated by human eosinophils. Science 234:200–203.

    PubMed  CAS  Google Scholar 

  • Werner, E., and Werb, Z. (2002). Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. J Cell Biol 158:357–368.

    PubMed  CAS  Google Scholar 

  • White, E., Shannon, J. S., and Patterson, R. E. (1997). Relationship between vitamin and calcium supplement use and colon cancer. Cancer Epidemiol Biomarkers Prev 6:769–774.

    PubMed  CAS  Google Scholar 

  • Winterbourn, C. C. (1993). Superoxide as an intracellular radical sink. Free Radic Biol Med 14:85–90.

    PubMed  CAS  Google Scholar 

  • Wu, G., and Morris, S. M. (1998). Arginine metabolism: nitric oxide and beyond. Biochem J 336:1–17.

    PubMed  CAS  Google Scholar 

  • Young, M., Newby, M., and Wepsic, T. (1987). Hematopoiesis and suppressor bone marrow cells in mice bearing large metastatic Lewis lung carcinoma tumors.Cancer Res 47:100–105.

    Google Scholar 

  • Zea, A. H., Rodriguez, P. C., Atkins, M. B., Hernandez, C., Signoretti, S., Zabaleta, J., McDermott, D., Quiceno, D., Youmans, A., O’Neill, A., Mier, J., and Ochoa, A. C. (2005). Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. Cancer Res 65:3044–3048.

    PubMed  CAS  Google Scholar 

  • Zhu, Q. S., Xia, L., Mills, G. B., Lowell, C. A., Touw, I. P., and Corey, S. J. (2006). G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood 107:1847–1856.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. H. Lee Moffitt Cancer Center, MRC 2067, 12902 Magnolia Dr., Tampa, FL 33612, USA

    Dmitry I. Gabrilovich

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  1. Alex Corzo
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  2. Srinivas Nagaraj
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  3. Dmitry I. Gabrilovich
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  1. H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA

    Dmitry I. Gabrilovich

  2. Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD 21071, USA

    Arthur A. Hurwitz

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Corzo, A., Nagaraj, S., Gabrilovich, D.I. (2008). Role of Reactive Oxygen Species in T-Cell Defects in Cancer. In: Gabrilovich, D.I., Hurwitz, A.A. (eds) Tumor-Induced Immune Suppression. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69118-3_12

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