Advertisement

Comparison of DNA Replication in Xenopus laevis and Simian Virus 40

  • Maren Oehlmann
  • Cathal Mahon
  • Heinz-Peter Nasheuer
Part of the Advances In Experimental Medicine And Biology book series (AEMB, volume 604)

DNA replication is a fundamental process within the cell cycle. The exact duplication of the genetic information ensures genome stability. Extensive research has identified the principal players required for the sequential processes: originlicensing (a controlled order of events giving a chromosome site the potential to be initiated within the S phase of the same cell cycle); initiation (by removing the license a previous licensed site is transformed into a site where the DNA helix starts to melt); and DNA replication (copying the parental DNA by leading and lagging strand DNA-synthesis). The present report compares the advantages and limitations of studying DNA replication in the model systems Xenopus laevis (X. laevis) and in Simian Virus 40 (SV40).

Keywords

Proliferate Cell Nuclear Antigen Xenopus Laevis Simian Virus Origin Recognition Complex SV40 Origin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer 2007

Authors and Affiliations

  • Maren Oehlmann
    • 1
  • Cathal Mahon
    • 1
  • Heinz-Peter Nasheuer
    • 1
  1. 1.Department of BiochemistryNational University of IrelandIreland

Personalised recommendations