Blood Levels of Organochlorine Pesticide Residues and Risk of Reproductive Tract Cancer Among Women from Jaipur, India
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 617)
Residuesof organochlorine pesticides are integral part of our environment.Because of their strong lipophilic and non-biodegradable nature, organisms at higher trophic levels in the food chain tend to accumulate them. The aim of the present study was to assess the influence of organochlorine pesticides upon the occurrence of reproductive tract cancers in women from Jaipur, India. Blood samples were collected from 150 females. In that group, 100 females suffered from reproductive tract cancers like cervical, uterine, vaginal and ovarian cancers, while the rest did not suffer from cancers or any other major disease and were treated as control group. The collected blood samples were subjected to pesticide extraction and analyzed with the help of gas chromatography. The pesticides detected were benzene hexa chlororide and its isomers, dieldrin, heptachlor, dichloro diphenyl trichloro ethane and its metabolites. The data obtained indicate that the organochlorine pesticide residue levels were significantly higher in all the cancer patients as compared with the control group.
KeywordsEstrogen Receptor Pesticide Residue Organochlorine Pesticide Dichloro Diphenyl Trichloro Ethane Clear Cell Adenocarcinoma
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