Estrogen-Receptor-Related Receptors and Hormone-Dependent Cancers

  • Olivia Lanvin
  • Stéphanie Bianco
  • Jean-Marc Vanacker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 617)

Nuclear receptors (NRs) comprise a superfamily of ligand-dependent transcription factors that all share similar modular structures (1). A highly conserved DNA-binding domain (DBD), located toward the center of the NR, mediates recognition of specific response elements (REs) within the promoters of target genes. The C-terminus contains a less conserved ligand-binding domain (LBD), which is responsible for ligand-recognition, homo- or hetero-dimerization, interaction with co-modulators, and activation of target gene transcription. A number of NRs, termed “orphan” receptors, display features similar to those found in the “classical” (i.e., “liganded”) receptors, including a putative LBD, but for which no natural ligand has been characterized (2). Whether such ligands indeed exist, or whether orphan receptors can activate transcription in a constitutive manner is still subject to debate.


Orphan Receptor Orphan Nuclear Receptor Lactoferrin Gene Constitutive Manner Specific Response Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2008

Authors and Affiliations

  • Olivia Lanvin
  • Stéphanie Bianco
  • Jean-Marc Vanacker
    • 1
  1. 1.INSERM EMI 229 Centre de Recherche en CancerologieMontpellierFrance

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