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Castration-Recurrent Prostate Cancer Is Not Androgen-Independent

  • James L. Mohler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 617)

In the USA in 2006, an estimated 234,460 new cases of prostate cancer (PC) will be diagnosed and 27,350 men will die from PC (1). Despite the increased use of digital rectal examination and serum prostate-specific antigen (PSA) measurement for early detection, ∼30% of men treated with curative intent suffer PC recurrence. These men and those who present with locally advanced or metastatic PC can be palliated by androgen deprivation therapy (ADT), a treatment that remains unimproved since its discovery more than 60 years ago (2). Over 80% of men with disseminated PC demonstrate clinical or biochemical response that is associated with a mean life expectancy of ∼3.5 years in contrast to nonresponders or untreated patients who live an average of 9 months. Regardless of the androgen responsiveness of incurable PC, almost all patients succumb to castration-recurrent PC because it responds poorly to all known therapies.

Keywords

Prostate Cancer Androgen Receptor Androgen Deprivation Therapy Androgen Receptor Gene Adrenal Androgen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2008

Authors and Affiliations

  • James L. Mohler
    • 1
  1. 1.Urologic Oncology University of North CarolinaChapel HillUSA

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